Immunogenicity of IpaC-hybrid proteins expressed in the Shigella flexneri 2a vaccine candidate SC602

Infection and Immunity

Volumn 66, Issue 1, 1998, Pages 77-82

  Bârzu, Simona ^a   Arondel, Josette ^b   Guillot, Sophie ^c   Sansonetti, Philippe J ^b   Phalipon, Armelle ^a,d  

^a U389 Institut National de la Santé et de la Recherche Médicale

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; CARRIER PROTEIN; EPITOPE; FREUND ADJUVANT; HYBRID PROTEIN; NEUTRALIZING ANTIBODY; SHIGELLA VACCINE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; GENE INSERTION; GENETIC VARIABILITY; IMMUNIZATION; IMMUNOGENICITY; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOMBINANT PLASMID; SHIGELLA FLEXNERI; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 2642691665     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.1.77-82.1998     Document Type: Article

References (26)

1. Barzu, S., A. Fontaine, P. J. Sansonetti, and A. Phalipon. 1996. Induction of a local anti-IpaC antibody response in mice by use of a Shigella flexneri 2a vaccine candidate: implications for use of IpaC as a protein carrier. Infect. Immun. 6-4:1190-1196.
2. Barzu, S., Z. Benjelloun-Touimi, A. Phalipon, P. J. Sansonetti, and C. Parsot. 1997. Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis. Infect. Immun. 65:1599-1605.
3. Barzu, S. Unpublished data.
4. Baudry, B., M. Kaczorek, and P. J. Sansonetti. 1988. Nucleotide sequence of the invasion plasmid antigen B and C genes (ipaB and ipaC) of Shigella flexneri. Microb. Pathog. 4:354-357
5. Charbit, A., J. Ronco, V. Michel, C. Werts, and M. Hofnung. 1991. Permissive sites and the topology of an outer membrane protein with a reporter cpitopc. J. Bactcriol. 173:262-275.
6. Chatfield, S. N., G. Dougan, and M. Roberts. 1994. Progress in the development of multivalcnt oral vaccines based on live attenuated Salmonella, p. 55-86. In E. Kurstak (ed.). Modern vaccinoloay. Plenum Medical, New York, N.Y.
7. De Geyter, C., B. Vogt, Z. Benjelloun-Touimi, P. J. Sansonetti, J. M. Ruysschaert, C. Parsot, and V. Cabiaux. 1997. Interaction of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells, with lipid membranes. FEBS Lett. 400:149-154.
8. Etcheverria, P. 1995. Unpublished data.
9. Hale, L., and P. J. Sansonetti. Unpublished data.
10. Kraehenbühl, J. P., and M. Neutra. 1992. Molecular and cellular basis of immune protection of mucosal surfaces. Physiol. Rev. 72:853-879.
11. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685
12. Leclere, C., P. Martineau, S. Van der Werf, E. Ueriaud, P. Duplay, and M. Hofnung. 1990. Induction of virus-neutralizing antibodies by bacteria expressing the C3 poliovirus cpitope in the pcriplasm. J. Immunol. 144:3174-3182.
13. Leclerc, C., R. Lo-Man, C. Fajolle, A. Charbit, J. M. Clement, P. Martincau, D. O'Callagnan, and M. Hofnung. 1994. Recombinant vectors in vaccine developcmcnt. Dev. Biol. Stand. 82:193-199.
14. Ménard, R., P. J. Sansonetti, and C. Parsot. 1993. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J. Bacteriol. 175:5899-5906.
15. Noriega, F. R., J. Y. Wang, G. Losonsky, D. R. Maneval, D. M. Hone, and M. M. Levine. 1994. Construction and characterization of attenuated ΔaroA ΔirG Shigella flexneri 2a strain CVD1203, a prototype live oral vaccine. Infect. Immun. 62:5168-5172.
16. Noriega, F. R., G. Losonsky, J. Y. Wang, S. Formal, and M. M. Levine. 1996. Further characterization of ΔaroA Δ virG Shigella flexneri 2a strain CVD 1203 as a mucosal Shigella vaccine and as a live-vector vaccine for delivering antigens of enlerotoxigenic Eseheriehia coli. Infect. Immun. 64:23-27.
17. O'Callaghan, D., A. Charbil, P. Martineau, C. Ledere, S. Van der Werf, C. Nauciel, and M. Hofnung. 1990. Immunogenicily of foreign peptide cpitopcs expressed in bacterial envelope proteins. Res. Microbiol. 141:963-969.
18. O'Callaghan, D, P. Martineau, C. Fajolle, C. Leclerc, J. G. Guillet, A. Charbit, and M. Hofnung. 1993. Immune responses to hybrid maltosebinding proteins. Vaccine 11:140-142.
19. Parsot, C, R. Ménard, P. Gounon, and P. J. Sansonetti. 1995. Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolccular structures. Mol. Microbiol. 16:291-300.
20. Phalipon, A., J. Arondel, F. Nato, S. Rouyre, J. C. Mazié, and P. J. Sansonetti. 1992. Identification and characterization of B-cell epitopes of IpaC, an invasion-associated protein of Shigella flexneri. Infect. Immun. 60:1919-1926.
21. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
22. Sansonetli, P. J. 1994. Molecular mechanisms of cell and tissue invasion by Shigella flexneri. Infect. Agents Dis. 2:201-206.
23. Schōdel, F., and R. Curtiss III. 1995. Salmonellae as oral vaccine carriers. Dev. Biol. Stand. 84:245-253.
24. Turbyfill, K. R., S. W. Joseph, and E. V. Oaks. 1995. Recognition of three epitopic regions on invasion plasmid antigen C by immune sera of rhesus monkeys infected with Shigella flexneri 2a. Infect. Immun. 63:3927-3935.
25. Van der Werf, S., A. Charbit, C. Ledere, V. Mimic, J. Ronco, M. Girard, and M. Hofnung. 1990. Critical role of neighbouring sequences on the immunogenicity of the C3 poliovirus neutralization epitope expressed at the surface of recombinant bacteria. Vaccine 8:269-277.
26. Wychowski, C., S. Van der Werf, O. Sifiert, R. Crainic, P. Bruneau, and M. Girard. 1983. A poliovirus type 1 neutralization epitope is located within amino acid residues 93 to 104 of viral eapsid polypeptide VP1. EMBO J. 2:2019-2023.