Molecular cytogenetic analysis in splenic lymphoma with villous lymphocytes: Frequent allelic imbalance of the RB1 gene but not the D13S25 locus on chromosome 13q14

Cancer Research

Volumn 58, Issue 8, 1998, Pages 1736-1740

  García Marco, José A ^a   Nouel, Amara ^a   Navarro, Blanca ^a   Matutes, Estella ^a   Oscier, David ^c   Price, Cathy M ^b   Catovsky, Daniel ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; B CELL LYMPHOMA; CANCER GENETICS; CHROMOSOME 13Q; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LYMPHOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE;

AGED; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 13; CYTOGENETICS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LYMPHOMA, B-CELL; MALE; RETINOBLASTOMA PROTEIN; SPLENIC NEOPLASMS; TRISOMY;

EID: 2642636871     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Fitchett, M., Griffiths, M. J., Oscier, D. G., Johnson, S., and Seabright, M. Chromosome abnormalities involving band 13q14 in hematologic malignancies. Cancer Genet. Cytogenet., 24: 143-150, 1987.
2. Harbour, J. W., Lai, S. L., Whang-Peng, J., Gazdar, A. F., Minna, J. D., and Kaye, F. J. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science (Washington DC), 241: 353-357, 1988.
3. Johansson, B., Mertens, F., and Mitelman, F. Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci. Genes Chromosomes Cancer, 8: 205-218, 1993.
4. Cooney, K. A., Wetzel, J. C., Merajver, S. D., Macoska, J. A., Singleton, T. P., and Wojno, K. J. Distinct regions of allelic loss on 13q in prostate cancer. Cancer Res., 56: 1142-1145, 1996.
5. Maestro, R., Piccinin, S., Doglioni, C., Gasparotto, D., Vukosavljevic, T., Sulfaro, S., Barzan, L., and Boiocchi, M. Chromosome 13q deletion mapping in head and neck squamous cell carcinomas: identification of two distinct regions of preferential loss. Cancer Res., 56: 1146-1150, 1996.
6. Tamura, K., Zhang, X., Murakami, Y., Hirohashi, S., Xu, H. J., Hu, S. X., Benedict, W. F., and Sekiya, T. Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer. Int. J. Cancer, 74: 45-49, 1997.
7. Marshall, C. J. Tumor suppressor genes. Cell, 64: 313-326, 1991.
8. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
9. Sherr, C. J. Cancer cell cycles. Science (Washington DC), 274: 1672-1677, 1996.
10. Benedict, W. F., Xu, H-J., Hu, S-X., and Takahashi, R. Role of the retinoblastoma gene in the initiation and progression of human cancer. J. Clin. Invest., 85: 988-993, 1990.
11. Chen, Y-C., Chen, P-J., Yeh, S-H., Tien, H-F., Wang, C-H., Tang, J-L., and Hong, R-L. Deletion of the human retinoblastoma gene in primary leukemias. Blood, 76: 2060-2064, 1990.
12. Ginsberg, A. M., Raffeld, M., and Cossman, J. Inactivation of the retinoblastoma gene in human lymphoid neoplasms. Blood, 77: 833-840, 1991.
13. Dao, D. D., Sawyer, J. R., Epstein, J., Hoover, R. G., Barlogie, B., and Tricot, G. Deletion of the retinoblastoma gene in multiple myeloma. Leukemia (Baltimore), 8: 1280-1284, 1994.
14. Liu, Y., Hermanson, M., Grandér, D., Merup, M., Wu, X., Heyman, M., Rasool, O., Juliusson, G., Gahrton, G., Detlofsson, R., Nikiforova, N., Buys, C., Söderhäll, S., Yankovsky, N., Zabarovsky, E., and Einhorn, S. 13q deletions in lymphoid malignancies. Blood, 86: 1911-1915, 1995.
15. INK4B, p53, and Rb genes in primary lymphoid malignancies. Blood, 87: 4949-4958, 1996.
16. Jamal, R., Gale, R. E., Thomas, N. S. B., Wheatley, K., and Linch, D. C. The retinoblastoma gene (rb1) in acute myeloid leukaemia: analysis of gene rearrangements, protein expression and comparison of disease outcome. Br. J. Haematol., 94: 342-351, 1996.
17. Melo, J. V., Hegde, U., Parreira, A., Thompson, I., Lampert, I. A., and Catovsky, D. Splenic lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens. J. Clin. Pathol. (Lond.), 40: 642-651, 1987.
18. Mulligan, S. P., and Catovsky, D. Splenic lymphoma with villous lymphocytes. Leuk. Lymphoma, 6: 97-105, 1992.
19. Isaacson, P. G., Matutes, E., Burke, M., and Catovsky, D. The histopathology of splenic lymphoma with villous lymphocytes. Blood, 84: 3828-3834, 1994.
20. Oscier, D. G., Matutes, E., Gardiner, A., Glide, S., Mould, S., Brito-Babapulle, V., Ellis, J., and Catovsky, D. Cytogenetic studies in splenic lymphoma with villous lymphocytes. Br. J. Haematol., 85: 487-491, 1993.
21. Solé, F., Woessner, S., Florensa, L., Montero, S., Asensio, A., Besses, C., and Sans-Sabrafen, J. A new chromosomal anomaly associated with mature B-cell chronic lymphoproliferative disorders: del(7)(q32). Cancer Genet. Cytogenet., 65: 170-172, 1993.
22. Oscier, D. G., Gardiner, A., and Mould, S. Structural abnormalities of chromosome 7q in chronic lymphoproliferative disorders. Cancer Genet. Cytogenet., 92: 24-27, 1997.
23. Stilgenbauer, S., Döhner, H., Bulgay-Mörschel, M., Weitz, S., Bentz, M., and Lichter, P. High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood, 81: 2118-2124, 1993.
24. Brown, A. G., Ross, F. M., Dunne, E. M., Steel, C. M., and Weir-Thompson, E. M. Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene. Nat. Genet., 3: 67-72, 1993.
25. Hawthorn, L. A., Chapman, R., Oscier, D., and Cowell, J. K. The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the DI3S25 locus which lies distal to the retinoblastoma predisposition gene. Oncogene, 8: 1415-1419, 1993.
26. Liu, Y., Szekely, L., Grander, D., Söderhäll, S., Juliusson, G., Gahrton, G., Linder, S., and Einhorn, S. Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus. Proc. Natl. Acad. Sci. USA, 90: 8697-8701, 1993.
27. Chapman, R., Corcoran, M. M., Gardiner, A., Hawthorn, L. A., Cowell, J. K., and Oscier, D. G. Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia. Oncogene, 9: 1289-1293, 1994.
28. Devilder, M. C., Franéois, S., Bosic, C. Moreau, A., Mellerin, M. P., Le Paslier, D., Bataille, R., and Moisan, J. P. Deletion cartography around the D13S25 locus in B cell chronic lymphocytic leukemia and accurate mapping of the involved tumor suppressor gene. Cancer Res., 55: 1355-1357, 1995.
29. Bullrich, F., Veronese, M. L., Kitada, S., Jurlander, J., Caligiuri, M. A., Reed, J. C., and Croce, C. M. Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia. Blood, 88: 3109-3115, 1996.
30. Matutes, E., Morilla, R., Owusu-Ankomah, K., Houlihan, A., and Catovsky, D. The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders. Blood, 83: 1558-1562, 1994.
31. Mitelman, F. ISCN 1995: an International System for Human Cytogenetic Nomenclature. Basel: Karger, 1995.
32. Garcia-Marco, J. A., Caldas, C., Price, C. M., Wiedemann, L. M., Ashworth, A., and Catovsky, D. Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia. Blood, 88: 1568-1575, 1996.
33. Mulligan, S. P., Matutes, E., Dearden, C., and Catovsky, D. Splenic lymphoma with villous lymphocytes: natural history and response to treatment in 50 patients. Br. J. Haematol., 78: 206-209, 1991.
34. Sun, T., Susin, M., Brody, J., Dittmar, K., Teichberg, S., Weiner, R., Lin, J. H., and Felber, N. Splenic lymphoma with circulating villous lymphocytes: report of seven cases and review of the literature. Am. J. Hematol., 45: 39-50, 1994.
35. Troussard, X., Valensi, F., Duchayne, E., Garand, R., Felman, P., Tulliez, M., Henry, A. M., Bryon, P. A., and Flandrin, G. Splenic lymphoma with villous lymphocytes: clinical presentation, biology and prognostic factors in a series of 100 patients. Groupe Francais d'Hematologie Cellulaire (GFHC). Br. J. Haematol., 93: 731-736, 1996.
36. Brito-Babapulle, V., Ellis, J., Matutes, E., Oscier, D., Khokhar, T., MacLennan, K., and Catovsky, D. Translocation t(11;14)(q13;q32) in chronic lymphoid disorders. Genes Chromosomes Cancer, 5: 158-165, 1992.
37. Liu, Y., Grandér, D., Söderhäll, S., Juliusson, G., Gahrton, G., and Einhorn, S. Retinoblastoma gene deletions in B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer, 4: 250-256, 1992.
38. Döhner, H., Pilz, T., Fischer, K., Cabot, G., Diehl, D., Fink, T., Stilgenbauer, S., Bentz, M., and Lichter, P. Molecular cytogenetic analysis of RB-1 deletions in chronic B-cell leukemias. Leuk. Lymphoma, 16: 97-103, 1994.
39. Brat, D. J., Hahn, S. A., Griffin, C. A., Yeo, C. J., Kern, S. E., and Hruban, R. H. The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma. Am. J. Pathol., 150: 383-391, 1997.
40. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
41. Garcia-Marco, J. A., Price, C. M., and Catovsky, D. Interphase cytogenetics in chronic lymphocytic leukemia. Cancer Genet. Cytogenet., 94: 52-58, 1997.
42. Cheng, J., Scully, P., Shew, J-Y., Lee, W-H., Vila, V., and Haas, M. Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line. Blood, 75: 730-735, 1990.
43. Knudson, A. G. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res., 45: 1437-1443, 1985.