Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: Circulating levels of IGF-I and IGF-binding proteins in transgenic mice

European Journal of Endocrinology

Volumn 137, Issue 6, 1997, Pages 701-708

  Blackburn, Alexia ^a   Dressendörfer, Regina A ^b   Blum, Werner F ^c   Erhard, Michael ^a   Brem, Gottfried ^d   Strasburger, Christian J ^b   Wolf, Eckhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c LILLY DEUTSCHLAND GMBH   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; GROWTH HORMONE; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PROTEIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; FEMALE; GROWTH HORMONE; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; LIGANDS; MALE; MICE; MICE, TRANSGENIC;

EID: 2642632787     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1370701     Document Type: Article

References (38)

1. DeChiara TM, Efstratiadis A & Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990 345 78-80.
2. DeChiara TM, Robertson EJ & Efstratiadis A. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 1991 64 849-859.
3. Baker J, Liu J-P, Robertson EJ & Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993 75 73-82.
4. Wang ZQ, Fung MR, Barlow DP & Wagner EF. Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature 1994 372 464-467.
5. Lau MMH, Stewart CEH, Liu Z, Bhatt H, Rotwein P & Stewart CL. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes and Development 1994 8 2953-2963.
6. Gluckman PD & Ambler GR. What is the function of circulating insulin-like growth factor-2 in postnatal life? Molecular and Cellular Endocrinology 1993 92 C1-C3.
7. Rogler CE, Yang D, Rossetti L, Donohoe J, Alt E, Chang CJ, Rosenfeld R, Neely K & Hintz R. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. Journal of Biological Chemistry 1994 269 13779-13784.
8. Wolf E, Kramer R, Blum WF, Föll J & Brem G. Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology 1994 135 1877-1886.
9. van Buul-Offers SC, de Haan K, Reijnen-Gresnigt MG, Meinsma D, Jansen M, Oei SL, Bonte EJ, Sussenbach JS & Van den Brande JL. Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus. Journal of Endocrinology 1995 144 491-502.
10. Ward A, Bates P, Fisher R, Richardson L & Graham CF. Disproportionate growth in mice with Igf-2 transgenes. Proceedings of the National Academy of Sciences of the USA 1994 91 10365-10369.
11. Wolf E, Rapp K, Blum WF, Kolb H & Brem G. Skeletal growth of transgenic mice with elevated levels of circulating insulin-like growth factor-II. Growth Regulation 1995 5 177-184.
12. Blackburn A, Schmitt A, Schmidt P, Wanke R, Hermanns W, Brem G & Wolf E. Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice. Transgenic Research 1997 6 213-222.
13. McCusker RH & Clemmons DR. The insulin-like growth factor binding proteins: structure and biological functions. In The Insulin-like Growth Factors: Structure and Biological Functions, pp 110-150. Ed PN Schofield. Oxford, New York, Tokyo: Oxford University Press, 1992.
14. Douglas RG, Gluckman PD, Ball K, Breier BH & Shaw JHF. The effects of insulin-like growth factor (IGF) I, IGF-II, and insulin on glucose and protein metabolism in fasted lambs. Journal of Clinical Investigation 1991 88 614-622.
15. Wilson DM, Thomas JA, Hamm TE, Wyche J, Hintz RL & Rosenfeld RG. Transplantation of IGF-II secreting tumours into nude rodents. Endocrinology 1987 120 1896-1901.
16. McGrane MM, de Vente J, Yun J, Bloom J, Park E, Wynshaw-Boris A, Wagner T, Rottman FM & Hanson RW. Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice. Journal of Biological Chemistry 1988 263 11443-11451.
17. Wolf E, Wanke R, Schenck E, Hermanns W & Brem G. Effects of growth hormone overproduction on grip strength of transgenic mice. European Journal of Endocrinology 1995 133 735-740.
18. Blum WF, Ranke MB & Bierich JR. A specific radioimmunoassay for insulin-like growth factor II: the interference of IGF binding proteins can be blocked by excess IGF-I. Acta Endocrinologica 1988 118 374-380.
19. Blum WF, Gallaher B & Ranke MB. An IGFBP-blocked IGF-I RIA that measures what it pretends to measure: IGF-I. 74th Annual Meeting of The Endocrine Society, San Antonio TX 1992, p 293.
20. Blum WF & Breier BH. Radioimmunoassays for insulin-like growth factors and their binding proteins. Growth Regulation 1994 4 (Suppl 1) 11-19.
21. Blum WF, Horn N, Kratzsch J, Jorgensen JOL, Juul A, Teale D, Mohnike K, Ranke MB. Clinical studies of IGFBP-2 by radioimmunoassay. Growth Regulation 1993 3 100-103.
22. Erhard MH, Kellner J, Schmidhuber S, Schams D & Lösch U. Identification of antigenic differences of recombinant and pituitary bovine growth hormone using monoclonal antibodies. Journal of Immunoassay 1994 15 1-19.
23. Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S & Binoux M. Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies. Analytical Biochemistry 1986 154 138-143.
24. SAS Institute Inc. SAS/STAT™ User's Guide, pp 549-640. Cary, NC: SAS Institute Inc., 1988.
25. Koea JB, Breier BH, Shaw JHF & Gluckman PD. A possible role for IGF-II: evidence in sheep for in vivo regulation of IGF-I mediated protein anabolism. Endocrinology 1992 130 2423-2425.
26. Zapf J, Walter H & Froesch ER. Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. Journal of Clinical Investigation 1981 68 1321-1330.
27. Breier BH, Milsom SR, Blum WF, Schwander J, Gallaher BW & Gluckman PD. Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone stimulated galactopoiesis in normally lactating women. Acta Endocrinologica 1993 129 427-435.
28. Guler H, Zapf J, Schmid C & Froesch ER. Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinologica 1989 121 753-758.
29. Camacho-Hubner C, Clemmons DR & D'Ercole AJ. Regulation of insulin-like growth factor (IGF) binding proteins in transgenic mice with altered expression of growth hormone and IGF-I. Endocrinology 1991 129 1201-1206.
30. Gosteli-Peter M, Winterhalter KH, Schmid C, Froesch ER & Zapf J. Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology 1994 135 2558-2567.
31. Baxter RC, Holman SR, Corbould A, Stranks S, Ho PJ & Braund W. Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. Journal of Clinical Endocrinology and Metabolism 1995 80 2700-2708.
32. Bereket A, Lang CH, Blethen SL & Wilson TA. Insulin-like growth factor-binding protein-2 and insulin: studies in children with type 1 diabetes mellitus and maturity-onset diabetes of the young. Journal of Clinical Endocrinology and Metabolism 1995 80 3647-3652.
33. Guo YS, Townsend CM Jr, Jin GF, Beauchamp RD & Thompson JC. Differential regulation by TGF-beta 1 and insulin of insulin-like growth factor binding protein-2 in IEC-6 cells. American Journal of Physiology 268 E1199-E1204.
34. de Herder WW, van der Lely AJ, Janssen JA, Uitterlinden P, Hofland LJ & Lamberts SW. IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly. Clinical Endocrinology 1995 43 501-505.
35. Blum WF, Albertsson-Wikland K, Rosberg S & Ranke MB. Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 1993 76 1610-1616.
36. Grinspoon S, Clemmons D, Swearingen B & Klinbanski A. Serum insulin-like growth factor-binding protein-3 levels in the diagnosis of acromegaly. Journal of Clinical Endocrinology and Metabolism 1995 80 927-932.
37. Chow JC, Murray JD, Pomp D, Baldwin RL, Calvert CC & Oberbauer AM. Regulation of insulin-like growth factor-I and binding protein-3 expression in oMtla-oGH transgenic mice. Transgenic Research 1994 3 127-133.
38. Palmer RM, Loveridge N, Thomson BM, Mackie SC, Tonner E & Flint DJ. Effects of a polyclonal antiserum to rat growth hormone on circulating insulin-like growth factor (IGF)-I and IGF-binding protein concentrations and the growth of muscle and bone. Journal of Endocrinology 1994 142 85-91.