Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart

Journal of Physiology and Pharmacology

Volumn 48, Issue 4, 1997, Pages 737-749

  Maczewski M ^a   Beresewicz A ^a  

^a MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

Author keywords

ATP sensitive potassium channel; Coronary flow; Endothelial dysfunction; Ischemia reperfusion; Isolated rat heart; Nitric oxide

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; ARGININE; GLIBENCLAMIDE; LINSIDOMINE; N(G) METHYLARGININE; N(G) NITROARGININE; NITRIC OXIDE; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL;

ANIMAL TISSUE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DOSE RESPONSE; ENDOTHELIUM; HEART; ISCHEMIA; MALE; NONHUMAN; RAT; REPERFUSION; SYNTHESIS; VASODILATATION;

ANIMALS; CORONARY VESSELS; GLYBURIDE; GUANIDINES; HEART; MALE; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; NITROARGININE; PINACIDIL; POTASSIUM CHANNELS; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 2642618600     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Moncada S, Palmer RMJ, Higgs ES. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142.
2. Samaha FF, Heineman FW, Ince C, Fleming J, Balaban RS. ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo. Am J Physiol 1992; 262: C1220-C1227.
3. von Beckerath N, Cyrys S, Dischner A, Daut J. Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanism. J Physiol (London) 1991; 442: 297-319.
4. Nelson MT, Quayle JM. Physiological roles and properties of potasium channels is arterial smooth muscle. Am J Physiol 1995; 268: C779-C822.
5. Duncker DJ, Vanzon NS, Altman JD, Pavek TJ, Bache RJ. Role of K+(ATP) channels in coronary vasodilation during exercise. Circulation 1993; 1245-1253.
6. Luscher TF, Tanner FC, Tschudi MR, Noll G. Endothelial dysfunction in coronary artery disease. Annu Rev Med 1993; 44: 395-418.
7. Tsao PS, Lefer AM. Time-course and mechanism of endothelial dysfunction in isolated ischemic-and hypoxic-perfused rat hearts. Am J Physiol 1990; 259: H1660-H1666.
8. Defily DV, Chilian WM. Preconditioning protects coronary arteriolar endothelium from ischemia-reperfusion injury. A J Physiol 1993; 265: H700-H706.
9. Richard V, Kaeffer N, Trom C, Thuillez C. Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion. Circulation 1994; 89: 1254-1261.
10. Leipert B, Becker BF, Gerlach E. Different endothelial mechanism involved in coronary responses to known vasodilators. Am J Physiol 1992; 262: H1676-H1683.
11. Huckstorf C, Zanzinger J, Fink B, Bassenge E. Reduced nitric oxide formation causes coronary vasoconstriction and impaired dilator responses to endogenous agonists and hypoxia in dogs. Naunyn-Schmied Arch Pharmacol 1994; 349: 367-373.
12. Louie EK, Hariman RJ, Wang YG, Hwang MH, Loeb HS, Scanlon PJ. Impairment of myocardial vascular responsiveness after transient myocardial ischemia and reperfusion. Am Heart J 1994; 128: 1084-1091.
13. + channels in cultured vascular smooth muscle cells. Circ Res 1994; 74: 471-476.
14. + channel of vascular smooth muscle cells. FEBS Lett 1994; 345: 47-49.
15. Niiya K, Uchida S, Tsuji T, Olsson RA. Glibenclamide reduces the coronary vasoactivity of adenosine receptor agonists. J Pharmacol Exp Ther 1994; 271: 14-19.
16. + channel activation. Am J Physiol 1993; 265: H1289-H1293.
17. Kostic MM, Schrader J. Role of nitric oxide in reactive hyperemia in guinea pig heart. Circ Res 1992; 70: 208-212.
18. Woolfson RG, Patel VC, Neild GH, Yellon DM. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism. Circulation 1995; 91: 1545-1551.
19. Beresewicz A, Karwatowska-Prokopczuk E, Lewartowski B, Cedro-Ceremuzynska K. A protective role of nitric oxide in isolated ischaemic/reperfused rat heart. Cardiovasc Res 1995; 30: 1001-1008.
20. Matsunaga T, Okumura K, Tsunoda R, Tayama S, Tabuchi T, Yasue H. Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide. Amer J Physiol 1996; 39: H427-H434.
21. + channels, attenuates metabolic coronary vasodilation induced by pacing tachycardia in dogs. Circulation 1995; 92: 511-517.
22. Kanatsuka H, Sekiguchi N, Sato K et al. Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart. Circ Res 1992; 71: 912-922.
23. Olsson RA, Bunger R. Metabolic control of coronary flow. Prog Cardiovasc Dis 1987; 29: 369-387.
24. Yamabe H, Okumura K, Ishizaka H, Tsuhiya T, Yasue H. Role of endothelium-derived nitric oxide in myocardial reactive hyperemia. Am J Physiol 1992; 263:H8-H14.
25. Duncker DJ, Bache RJ. Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis. Circ Res 1994; 74: 629-640.
26. Jones CJH, Kuo L, Davis MJ, Defily DV, Chilian WM. Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand. Circulation 1995; 91: 1807-1813.
27. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 1995; 92: 320-326.
28. Parker RB, Waud DR. Pharmacological estimation of drug-receptor dissociation constants. Statistical evaluation. I. Agonists. J Pharmacol Exp Ther 1971; 177: 1-12.
29. Sato K, Kanatsuka H, Sekiguchi N et al. Effect of an ATP sensitive potassium channel opener, levcromakalim, on coronary arterial microvessels in the beating canine heart. Cardiovasc Res 1994; 28: 1780-1786.