Megatherapy in children with high-risk Ewing's sarcoma in first complete remission

Bone Marrow Transplantation

Volumn 21, Issue 8, 1998, Pages 795-799

  Madero, L ^a,d   Munoz A ^b   Sanchez De Toledo J ^c   Diaz M A ^a   Maldonado, M S ^b   Ortega, J J ^c   Ramirez M ^a   Otheo, E ^b   Benito, A ^a   Salas, S ^c  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

Author keywords

High risk Ewing's sarcoma; Megatherapy; Prognostic factors

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; BUSULFAN; CARBOPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; MELPHALAN; METHOTREXATE; VINCRISTINE;

ADULT; ARTICLE; CANCER REGRESSION; CANCER SURVIVAL; CHILD; CLINICAL ARTICLE; EWING SARCOMA; FEMALE; GASTROINTESTINAL SYMPTOM; HIGH RISK PATIENT; HUMAN; LIVER VENOOCCLUSIVE DISEASE; MALE; METASTASIS; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; NAUSEA; PELVIS TUMOR; PRIORITY JOURNAL; PROGNOSIS; SEPSIS; TUMOR VOLUME; VOMITING; WHOLE BODY RADIATION;

EID: 2642616991     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701189     Document Type: Article

References (35)

1. Crist WM, Kun LE. Common solid tumors of childhood. New Engl J Med 1991; 324: 461-471.
2. Jurgens H, Exner U, Gadner H et al. Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial. Cancer 1988; 61: 23-32.
3. Nesbit ME Jr, Gehan EA, Burgert EO Jr et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 1990; 8: 1664-1674.
4. Hayes FA, Thompson EI, Meyer WH et al. Therapy for localized Ewing's sarcoma of bone. J Clin Oncol 1989; 7: 208-213.
5. Wexler LH, DeLaney TF, Tsokos M et al. Ifosfamide and etoposide plus vincristine, doxorubicin, and cyclophosphamide for newly diagnosed Ewing's sarcoma family of tumors. Cancer 1996; 78: 901-911.
6. Hayes FA, Thompson EI, Parvey L et al. Metastatic Ewing's sarcoma: remission induction and survival. J Clin Oncol 1987; 5: 1199-1204.
7. Gobel V, Jurgens H, Etspuler G et al. Prognostic significance of tumor volume in localized Ewing's sarcoma of bone in children and adolescents. J Cancer Res Clin Oncol 1987; 113: 187-191.
8. Sauer R, Jurgens H, Burgers JM et al. Prognostic factors in the treatment of Ewing's sarcoma. The Ewing's Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. Radiother Oncol 1987; 10: 101-110.
9. Evans R, Nesbit M, Askin F et al. Local recurrence, rate and sites of metastases, and time to relapse as a function of treatment regimen, size of primary and surgical history in 62 patients presenting with non-metastatic Ewing's sarcoma of the pelvic bones. Int J Radiat Oncol Biol Phys 1985; 11: 129-136.
10. Wexler LH, DeLaney TF, Tsokos M et al. Ifosfamide and etoposide plus vincristine, doxorubicin, and cyclophosphamide for newly diagnosed Ewing's sarcoma family of tumors. Cancer 1996; 78: 901-911.
11. Bortin MM, Horowitz MM, Rowlings PA et al. 1993 Progress report from the International Bone Marrow Transplant Registry. Advisory Committee of the International Bone Marrow Transplant Registry. Bone Marrow Transplant 1993; 12: 97-104.
12. Armitage JO. Bone marrow transplantation. New Engl J Med 1994; 330: 827-838.
13. Sanders JE. Bone marrow transplantation in pediatric oncology. In: Pizzo PA, Poplack DG (eds). Principles and Practice of Pediatric Oncology, 3rd edn. Lippincott Raven: Philadelphia, 1997, pp 357-373.
14. Dunst J, Sauer R, Burgers JM et al. Radiation therapy as local treatment in Ewing's sarcoma. Results of the Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. Cancer 1991; 67: 2818-2825.
15. Rosen G, Caparros B, Nirenberg A et al. Ewing's sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 1981; 47: 2204-2213.
16. Meyer WH, Kun L, Marina N et al. Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone. J Clin Oncol 1992; 10: 1737-1742.
17. Thomas ED, Storb R, Clift RA et al. Bone-marrow transplantation. New Engl J Med 1975; 292: 832-843.
18. Díaz MA, Villa M, Alegre A et al. Collection and transplantation of peripheral blood progenitor cells mobilized by G-CSF alone in children with malignancies. Br J Haematol 1996; 94: 148-154.
19. Bearman SI, Appelbaum FR, Buckner CD et al. Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 1988; 6: 1562-1568.
20. Kinsella TJ, Miser JS, Waller B et al. Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. Int J Radiat Oncol Biol Phys 1991; 20: 389-395.
21. Cangir A, Vietti TJ, Gehan EA et al. Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing's sarcoma studies. Cancer 1990; 66: 887-893.
22. Picci P, Rougraff BT, Bacci G et al. Prognostic significance of histopathologic response to chemotherapy in nonmetastatic Ewing's sarcoma of the extremities. J Clin Oncol 1993; 11: 1763-1769.
23. Mendenhall CM, Marcus RB Jr, Enneking WF et al. The prognostic significance of soft tissue extension in Ewing's sarcoma. Cancer 1983; 51: 913-917.
24. Marcus RB Jr, Graham-Pole JR, Springfield DS et al. High-risk Ewing's sarcoma: end-intensification using autologous bone marrow transplantation. Int J Radiat Oncol Biol Phys 1988; 5: 53-59.
25. Horowitz ME, Kinsella TJ, Wexler LH et al. Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing's sarcoma and rhabdomyosarcoma. J Clin Oncol 1993; 11: 1911-1918.
26. Horowitz ME, Malaver MM, Woo SY et al. Ewing's sarcoma family of tumors. Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. In: Pizzo PA, Poplack DG (eds). Principles and Practice of Pediatric Oncology, 3rd edn. Lippincott Raven: Philadelphia, 1997, pp 831-836.
27. Hayes FA, Thompson EI, Parvey L et al. Metastatic Ewing's sarcoma: remission induction and survival. J Clin Oncol 1987 5: 1199-1204.
28. Straun D, Matthay KK, O'Leary M et al. Consolidation chemoradiotherapy and autologous bone marrow transplantation versus continued chemotherapy for metastatic neuroblastoma: a report of two Concurrent Children's Group Studies. J Clin Oncol 1996; 14: 2417-2426.
29. Cornbleet MA, Corringham RE, Prentice HG et al. Treatment of Ewing's sarcoma with high-dose melphalan and autologous bone marrow transplantation. Cancer Treat Rep 1981; 65: 241-244.
30. Graham-Pole J, Lazarus HM, Herzig RH et al. High-dose melphalan therapy for the treatment of children with refractory neuroblastoma and Ewing's sarcoma. Am J Pediatr Hematol Oncol 1984; 6: 17-26.
31. Burdach S, Jurgens H, Peters C et al. Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing's sarcoma. J Clin Oncol 1993; 11: 1482-1488.
32. Ladenstein R, Lasset C, Pinkerton CR et al. Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry. Bone Marrow Transplant 1995; 15: 697-705.
33. Madero L, Muñoz A, Ortega JJ et al. High dose therapy and autologous hematopoietic progenitor transplantation in Ewing's tumors in complete remission. Med Pediatr Oncol 1996; 27: 297 (Abstr. 42).
34. Mitchell PL, Shepherd VB, Proctor HM et al. Peripheral blood stem cells used to augment autologous bone marrow transplantation. Arch Dis Child 1994; 70: 237-240.
35. Stewart DA, Gyonyor E, Paterson AH et al. High-dose melphalan ± total body irradiation and autologous hematopoietic stem cell rescue for adult patients with Ewing's sarcoma or peripheral neuroectodermal tumor. Bone Marrow Transplant 1996; 18: 315-318.