Phenotypic changes in vascular smooth muscle cells during aging: Insulin effect on migration

Gerontology

Volumn 44, Issue 3, 1998, Pages 149-152

  Munoz F J ^a   Jimenez M ^a   Melon J ^b   Ruiz Torres, A ^a,b  

^a Univ Res Inst Gerontology Metab   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Aging; Chemotaxis; Collagen III; Insulin; Insulin like growth factor 1; Migration; Smooth muscle cells

Indexed keywords

CHEMOATTRACTANT; COLLAGEN; COLLAGEN TYPE 3; GROWTH FACTOR; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C;

ADULT; AGED; AGING; ARTICLE; ATHEROGENESIS; CELL MIGRATION; CHEMOTAXIS; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN BINDING; INSULIN RELEASE; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 2642614531     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000021999     Document Type: Article

References (25)

1. Lindner J: Altern des Bindegewebes, Handbuch der Allgemeinen Pathologie, Berlin, Springer, 1972, vol 6, pp 245-368.
2. Cox RH: Effect of age on the mechanical properties of rat carotid artery. Am J Physiol 1977;233:H256-H263.
3. Anversa P, Hiler B, Ricci G, Guideri G, Olivetti G: Myocyte cell loss and myocyte hypertrophy in the aging, rat heart. J Am Coll Cardiol 1986;8:1441-1448.
4. Desmoulière A, Gabbiani G: The cytoskeleton of arterial smooth muscle cells during human and experimental atheromatosis. Kidney Int 1992;41(suppl):87-89.
5. Copeland KC, Colletti RB, Davlin JT, McAuliffe TL: The relationship between insulin-like growth factor-1, adiposity and aging. Metabolism 1990;39:584-587.
6. Rudman D, Vintner MH, Rogers CM, Lubin MF, Fleming GH, Raymond PB: Impaired growth hormone secretions in the adult populations. Relation to age and adiposity. J Clin Invest 1981;67:1361-1369.
7. Palmer JP, Ensink JW: Acute phase insulin secretion and glucose tolerance in young and aged normal men and diabetic patients. J Clin Endocrinol Metab 1975;41:498-503.
8. Curry PT Jr, Safarik RH, Reaven E: Effect of age on the insulin secretory responses of perfused rat pancreas to arginine and tolbutamine. Horm Metab Res 1984;19:453-457.
9. Defronzo RA: Glucose intolerance and aging: Evidence for tissue insensitivity to insulin. Diabetes 1979;28:1095-1101.
10. 10: Ruiz-Torrres A, Vicent D, Sánchez de Paco G, Muñoz FJ, Gimeno A, Carraro R: Increase in insulin secretion with age: Its clinical importance in evaluating abnormal secretions focused on diabetes type II and obesity. Arch Gerontol Geriatr 1996;22:39-47.
11. Ruiz-Torres A, Melon J, Munoz FJ: Insulin stimulates collagen synthesis in vascular smooth muscle cells from elderly patients. Gerontology 1998;44:144-1481.
12. Boyden SV: The chemotactic effect of mixture of antibody and antigen on polymorphonuclear leukocytes. J Exp Med 1962;115:453-456.
13. Koyama N, Morisaki N, Saito Y, Yoshida S: Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells. J Biol Chem 1993;268:22806-22812.
14. Yabkowitz R, Mansfield PJ, Ryan US, Suchard SJ: Thrombospondin mediates migration and potentiates platelet-derived growth factor-dependent migration of calf pulmonary artery smooth muscle cells. J Cell Physiol 1993;157:24-32.
15. Yue H, Wang X, Sung CP, Olson B, McKenna PJ, Gu JL, Feuerstein GZ: Interleukin 8. A mitogen and chemoattractant for vascular smooth muscle cells. Circ Res 1994;75:1-7.
16. Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R: Insulin-like growth factor-1 and platelet-derived grorwth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest 1994;93:1266-1274.
17. Ross R: The pathogenesis of atherosclerosis. An update. N Engl J Med 1986:314:488-500.
18. Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993;362:801-809.
19. Grünwald J, Haudenschild CC: Intimai injury in vivo activates vascular smooth muscle cell migration and explant outgrowth in vitro. Arteriosclerosis 1984;4:183-188.
20. Gajdusek C, DiCorleto P, Ross R, Schwarte SM: An endothelial cell-derived growth factor. J Cell Biol 1980;85:467-472.
21. Stout RW: Insulin as a mitogenetic factor: Role in the pathogenesis of cardiovascular disease. Am J Med 1991;90:62-65
22. Wight LN: Cell biology of arterial proteoglycans. Arteriosclerosis 1989;9:1-20.
23. Libby P: Molecular bases of the acute coronary syndromes. Circulation 1995;91:2844-2850.
24. Bagdade JD, Bierman EL, Porte D: The significance of basal insulin in the evaluation of the insulin response to glucose in diabetic and non diabetic subjects. J Clin Invest 1967;46:1549-1557.
25. Numata K, Tanaka K, Saito M, Shishido T, Inoue S: Very low calorie diet-induced weight loss reverses exaggerated insulin secretion in response to glucose, arginine and glueagon in obesity. Int J Obes 1993;17:103-108.