Comparison of binding affinities of ω-conotoxin and amlodipine to N- type Ca2+ channels in rat brain

Acta Pharmacologica Sinica

Volumn 19, Issue 2, 1998, Pages 97-100

  Qu, Ying Li ^a,b   Sugiyama, Kentaro ^a   Ohnuki, Toshio ^a   Hattori, Kaoru ^a   Watanabe, Kenichi ^a   Nagatomo, Takafumi ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b 510 China World Tower   (China)

Author keywords

Amlodipine; Calcium channels; Conotoxin; Nifedipine; Radioligand assay; SM 6586

Indexed keywords

AMLODIPINE; BENIDIPINE; CALCIUM CHANNEL; ISRADIPINE; MANIDIPINE; NICARDIPINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; OMEGA CONOTOXIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN HOMOGENATE; BRAIN SYNAPTOSOME; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN TISSUE; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PKA; RAT; SCATCHARD PLOT;

AMLODIPINE; ANIMALS; BINDING SITES; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; MALE; OMEGA-CONOTOXIN GVIA; PEPTIDES; RADIOLIGAND ASSAY; RATS;

EID: 2642608656     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Qu Y, Sugiyama K, Nagatomo T, Maniwa T, Miyagishi A. Calcium channel blocking properties of SM-6586 in cat heart and brain as assessed by radioligand binding assay. Jpn J Pharmacol 1993; 63: 165-9.
2. 3H-isradipine binding sites in rat brain membrane pretreated with amlodipine. Acta Pharmacol Sin 1995; 16: 289-93.
3. 2+ channel antagonist amlodipine to dihydropyridine receptor sites in rat brain membranes. Gen Pharmacol 1996; 27: 137-40.
4. 3H-PN 200-110 binding sites in membranes of rat heart and brains. Biol Pharm Bull 1996; 19: 195-8.
5. McEnery MW. Purification and pharmacological analysis of the omega-conotoxin GVIA receptor from rat brain. In: Glossmann H, Striessning J, editors. Molecular and cellular biology of pharmacological targets. New York: Plenum Press; 1993. p 3-39.
6. Miller RJ. Multiple calcium channels and neuronal function. Science 1987; 235: 46-52.
7. 2+ -antagonistic effects of SM-6586 and its isomers, novel 1, 4-dihydropyridine derivatives, by radioligand binding assay. Jpn J Pharmacol 1992; 58: 75-8.
8. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ. Protein measurement with the Polin phenol reagent. J Biol Chem 1951; 193: 265-75.
9. 125I]ω-conotoxin GVIA binding sites in the rat frontal cortex and caudate nucleus. Brain Res 1992; 583: 189-93.
10. Ertel EA, Warren VA, Adams ME, Griffin PR, Cohen CJ, Smith MM. Type III ω-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels. Biochemistry 1994; 33: 5098-108.
11. Cruz U, Olivera BM. Calcium channel antagonists. J Biol Chem 1966; 261: 6230-3.
12. 2+ channel and the cation sensitivity of ω-conotoxing via binding. Neuropharmacology 1993; 32: 1127-39.
13. Boland LM, Morrill JA, Bean BP. ω-Conotoxin block of N-type calcium channel in frog and rat sympathetic neurons. J Neurosci 1994; 14: 5011-27.