Steroidal 'add-back' therapy in patients treated with GnRH agonists

Gynecologic and Obstetric Investigation

Volumn 45, Issue SUPPL. 1, 1998, Pages 22-30

  Freundl, G ^a,c   Godtke K ^a   Gnoth, Ch ^a   Godehardt, E ^a   Kienle, E ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b Takeda Pharma   (Germany)

^c Frauenklinik Benrath   (Germany)

Author keywords

Endometriosis; GnRH agonists; Oestrogens; Progestins; r AFS score; Steroid add back; Vasomotor symptoms

Indexed keywords

DESOGESTREL; ETHINYLESTRADIOL; GONADORELIN AGONIST; LEUPRORELIN;

ADULT; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DYSMENORRHEA; DYSPAREUNIA; ENDOMETRIOSIS; FEMALE; HEADACHE; HOT FLUSH; HUMAN; INSOMNIA; INTRAMUSCULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SWEATING;

ADULT; DELAYED-ACTION PREPARATIONS; DESOGESTREL; DOUBLE-BLIND METHOD; ENDOMETRIOSIS; ETHINYL ESTRADIOL; FEMALE; HOT FLASHES; HUMANS; LEUPROLIDE; PLACEBOS; PROSPECTIVE STUDIES; SLEEP INITIATION AND MAINTENANCE DISORDERS; SWEATING;

EID: 2642607037     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000052848     Document Type: Conference Paper

References (24)

1. Hoffmann G, Spitz J, Behrens R: GnRH-Agonisten in der Endometriosetherapie. Ther Umsch 1990;47:937-944.
2. Karck U, Neulen J, Wieacker P, Breckwoldt M: Übersicht: Gonadotropin-releasing Hormone (GnRH) und seine Analoga in der heutigen Medizin. Med Klin 1992;87:87-93.
3. Regidor PA, Schindler AE, Bühler K, Gerhard I, Kimmig R, Meinen K, Hoffmann G, Lübben G, Kienle E: Ergebnisse eines Langzeit Follow-up bei der Behandlung der Endometriose mit dem GnRH-Agonisten Leuprorelinacetat-Depot (Enantone-Gyn Monats-Depot). Zentralbl Gynäkol 1996;118:283-290.
4. Schindler AE, Bühler K, Gerhard I, Wiedemann R, Kimmig R, Schüsler B, Kranzfelder D, Mall-Häfeli M, Meinen K, Mancarella D, Hoffmann G, Kienle E: Behandlung der Endometriose mit dem GnRH-Agonisten Leuprorelinacetat Depot (Enantone-Gyn Monats-Depot): Eine multizentrische Studie. Zentralbl Gynäkol 1994;116:679-686.
5. Simonds DK: Add-back therapy in the treatment of endometriosis: The European experience. Br J Obstet Gynaecol 1996;103(suppl):10-13.
6. Adashi EY: Long-term gonadotropin-releasing hormone agonist therapy: The evolving issue of steroidal 'add-back' paradigms. Hum Reprod Update 1994;9:1380-1397.
7. Mezrow G, Shoupe D, Spicer D, Lobo R, Leung B, Pike M: Depot leuprolide acetate with estrogen and progestin add-back for long-term treatment of premenstrual syndrome. Fertil Steril 1994;62:932-937.
8. Kiesel L, Schweppe KW, Sillem M, Siebzehnrübl E: Should add-back therapy for endometriosis be deferred for optimal results? Br J Obstet Gynaecol 1996;103(suppl 14):15-17.
9. Surrey ES: Steroidal and nonsteroidal 'add-back' therapy: Extending safety and efficacy of gonadotropin-releasing hormone agonists in the gynecologic patient. Fertil Steril 1995;64:673-685.
10. Hughes EG, Fedorkow DM, Collins JA: A quantitative overview of controlled trials in endometriosis-associated infertility. Fertil Steril 1993;59:963-970.
11. Maouris P, Dowsett M, Pose G, Edmonds D: A new treatment for endometriosis. Lancet 1989; ii:1018.
12. Friedman AJ, Daly M, Juneau-Norcross M, Rein MS, Fine C, Gleason R, Leboff M: A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin 'add-back' regimens for women with leiomyomata uteri. J Clin Endocrinol Metab 1993;76:1439-1445.
13. Friedman AJ, Hornstein MD: Gonadotropin-releasing hormone agonist plus estrogen-progestin 'add-back' therapy for endometriosis-related pelvic pain. Fertil Steril 1993;60:236-241.
14. Kiilholma P, Tuimala R, Kivinen S, Korhonen M, Hagman E: Comparison of the gonadotropin-releasing hormone agonist goserelin acetate alone versus goserelin combined with estrogen-progestogen add-back therapy in the treatment of endometriosis. Fertil Stertil 1995;64:903-908.
15. Lindsay PC, Shaw RW, Coelingh Bennink HJ, Kicovic P: The effect of add-back treatment with tibolone (Livial) on patients treated with the gonadotropin-releasing hormone agonist triptorelin (Decapeptyl). Fertil Steril 1996;65:342-348.
16. Semm K.: Die 3-Phasen-Therapie der Endometriosis genitalis. XXXV. Wiss Zschr Ernst-Moritz-Arndt-Universität, Greifswald, 1986, pp 37-40.
17. Gödtke K, Freundl G, Gnoth CH: Effects of the add-back therapy on bone mineral density and pyridinium-crosslinks under central suppression by GnRH-agonists. XV FIGO World Congress of Gynecology and Obstetrics, Copenhagen, August 3-8, 1997.
18. Barbieri RL: Hormone treatment of endometriosis: The estrogen threshold hypothesis. Am J Obstet Gynecol 1992;166:740-745.
19. Howell R, Edmonds DK, Dowsett M, Crook D, Lees B, Stevenson JC: Gonadotropin-releasing hormone analogue (goserelin) plus hormone replacement therapy for the treatment of endometriosis: A randomized controlled trial. Fertil Steril 1995:64:474-481.
20. Studd J, Leather AT: The need for add-back with gonadotropin-releasing hormone agonist therapy. Br J Obstet Gynaecol 1996;103(suppl 14):1-4.
21. Surrey ES, Judd HL: Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: A prospective randomized trial. J Clin Endocrinol Metab 1992;75:558-561.
22. Eldred JM, Haynest PJ, Thomas EJ: A randomized double blind placebo controlled trial of the effects on bone metabolism of the combination of nafarelin acetate and norethisterone. Clin Endocrinol 1992;37:354-359.
23. Vercellini P, Trespidi L, Colombo A, Vendola N, Marchini M, Crosignani PG: A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril 1993;60:75-79.
24. Freundl G, Tigges J: Gynäkologische Endokrinologie für die Praxis. Jena, Fischer, 1995, pp 1-188.