Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats

Molecular Brain Research

Volumn 40, Issue 1, 1996, Pages 64-70

  Minami, Yuki ^a,b   Inoue, Kiyoshi ^b   Shimada, Shoichi ^b   Morimura, Hiroyuki ^b   Miyai, Akiko ^b   Yamauchi, Atsushi ^b   Matsunaga, Takashi ^a   Tohyama, Masaya ^b  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Cerebellum; Hybridization; Hypernatremia; In situ; Na+ myo inositol cotransporter; Osmolyte

Indexed keywords

INOSITOL; MESSENGER RNA; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL VOLUME; CONTROLLED STUDY; GENETIC TRANSCRIPTION; GRANULE CELL; HYPERNATREMIA; IN SITU HYBRIDIZATION; MALE; NONHUMAN; NORTHERN BLOTTING; OSMOREGULATION; PRIORITY JOURNAL; RAT; SODIUM BLOOD LEVEL;

ANIMALIA;

ANIMALS; BLOTTING, NORTHERN; BRAIN; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; IN SITU HYBRIDIZATION; KINETICS; MALE; MEMBRANE PROTEINS; RATS; RATS, WISTAR; RNA PROBES; RNA, MESSENGER; SODIUM; SYMPORTERS; TIME FACTORS; TRANSCRIPTION, GENETIC; WATER-ELECTROLYTE BALANCE; WATER-ELECTROLYTE IMBALANCE;

EID: 2642602759     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(96)00034-4     Document Type: Article

References (23)

1. [1] Arieff, A.I. and Guisado, R., Effects on the central nervous system of hypernatremic and hyponatremic states, Kidney Int., 10 (1976) 104-116.
2. [2] Cammarata, P.R. and Chen, H.-Q., Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. 1. A hypertonicity-induced protein enhances myo-inositol transport, Invest. Ophthalmol. Vis. Sci., 35 (1994) 1223-1235.
3. [3] Chan, P.H. and Fishman, R.A., Effects of rat brain amino acids, ammonia and idiogenic osmoles induced by hyperosmolality, Brain Res., 161 (1979) 293-301.
4. [4] Garcia-Perez, A. and Burg, M.B., Renal medullary organic osmolytes, Physiol. Rev., 71 (1991) 1081-1115.
5. [5] Gullans, S.R. and Verbalis, J.G., Control of brain volume during hyperosmolar and hypoosmolar conditions, Annu. Rev. Med., 44 (1993) 289-301.
6. [6] Handler, J.S. and Kwon, H.M., Regulation of renal cell organic osmolyte transport by tonicity, Am. J. Physiol., 265 (1993) C1449-C1455.
7. [7] Heilig, C.V., Stromski, M.E., Blumenfeld, J.B., Lee, J.B. and Gullans, S.R., Characterization of the major brain osmolytes that accumulate in salt-loaded rats, Am. J. Physiol., 257 (1989) F1108-F1116.
8. +/myo-inositol cotransporter, a hypertonicity stress protein, J. Biol. Chem., 267 (1992) 6297-6301.
9. [9] Law, R.O., Amino acids as volume-regulatory osmolytes in mammalian cells, Comp. Biochem. Physiol., 99A (1991) 263-277.
10. [10] Law, R.O., Regulation of mammalian brain cell volume, J. Exp. Zool., 268 (1994) 90-96.
11. [11] Lien, Y.-H.H., Shapiro, J.I. and Chan, L., Effects of hypernatremia on organic brain osmoles, J. Clin. Invest., 85 (1990) 1427-1435.
12. [12] Lohr, J.W., McReynolds, J., Grimaldi, T. and Acara, M., Effects of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney, Life Sci., 43 (1988) 271-276.
13. [13] Nakanishi, T., Turner, R.J. and Burg, M.B., Osmoregulatory changes in myo-inositol transport by renal cells, Proc. Natl. Acad. Sci. USA, 86 (1989) 6002-6006.
14. [14] Pollock, A.S. and Arieff, A.I., Abnormalitis of cell volume regulation and their functional consequences. Am. J. Physiol., 239 (1980) F195-F205.
15. [15] Somero, G.N., Protons, osmolytes, and fitness of internal milieu for protein function, Am. J. Physiol., 251 (1986) R197-R213.
16. [16] Strange, K., Morrison, R., Heilig, C.W., DiPietro, S. and Gullans, S.R., Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells, Am. J. Physiol., 260 (1991) C784-C790.
17. [17] Strange, K., Regulation of solute and water balance and cell volume in the central nervous system, J. Am. Soc. Nephrol., 3 (1992) 12-27.
18. [18] Thurston, J.H., Hauhart, R.E., Jones, E.M. and Ater, J.L., Effects of salt and water loading on carbohydrate and energy metabolism and levels of selected amino acids in the brains of young mice, J. Neurochem., 24 (1975) 953-957.
19. +-myo-inositol cotransporter in MDCK cells, Am. J. Physiol., 264 (1993) F20-F23.
20. +/myo-inositol cotransporter mRNA in rat kidney medulla, J. Am. Soc. Nephrol., 5 (1994) 62-67.
21. +/myo-inositol cotransporter in rat kidney, J. Clin. Invest., 96 (1995) 1195-1201.
22. [22] Yokoyama, T., Lin, L.R., Chakrapani, B. and Reddy, V.N., Hypertonic stress increases NaK ATPase, taurine, and myoinositol in human lens and retinal pigment epithelial cultures, Invest. Ophthalmol. Vis. Sci., 34 (1993) 2512-2517.
23. [23] Zhou, C., Agarwal, N. and Cammarata, P.R., Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. 2. Cloning of a 626 bp cDNA portion of a Na+/myo-inositol cotransporter, an osmotic shock protein, Invest. Ophthalmol. Vis. Sci., 35 (1994) 1236-1242.