Influence of food on the bioavailability of a carbamazepine slow-release formulation

International Journal of Clinical Pharmacology and Therapeutics

Volumn 35, Issue 12, 1997, Pages 557-560

  Retzow, A ^b   Schurer M ^a   Schulz, H U ^a  

^a Biopharmaceutical Analytics GmbH   (Germany)

^b ALK SCHERAX Arzneimittel GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE;

ADULT; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DROWSINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; FOOD DRUG INTERACTION; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MEAL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SLOW RELEASE FORMULATION; TABLET;

ADULT; ANTICONVULSANTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CARBAMAZEPINE; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; FASTING; FOOD-DRUG INTERACTIONS; HUMANS; INTESTINAL ABSORPTION; MALE;

EID: 2642595058     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Chelberg RD, Gunawan S, Treiman DM 1988 Simultaneous high-performance liquid Chromatographic determination of carbamazepine and its principal metabolites in human plasma and urine. Ther Drug Monit 10: 188-193
2. Hauschke D, Steinijans VW, Diletti E 1990 A distribution-free procedure for the statistical analysis of bioequivalence studies. Int J Clin Pharmacol Ther Toxicol 28: 72-78
3. Karim A, Burns Th, Wearley L, Streicher J, Palmer M 1985 Food-induced changes in theophylline absorption from controlled-release formulations. Pan I. Substantial increased and decreased absorption with Uniphyl tablets and Theo-Dur sprinkle. Clin Pharmacol Ther 38: 77-83
4. Krämer G, Tettenborn B, Geradin A, Dubois J-P 1989 Food and the absorption and bioavailability of carbamazepine (Tegretol). International Epilepsy Congress, New Delhi, 614
5. Levy RH, Pitlick WH, Traupin AS, Green JR, Neal JM 1975 Pharmacokinetics of carbamazepine in nurmal man. Clin Pharmacol Ther 17: 657-668
6. McLean AJ, McNamara PJ, duSouich P, Gibaldi M, Lalka U 1978 Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism. Clin Pharmacol Ther 24: 5-10
7. Melander A 1978 Influence of food on the bioavailability of drugs. Clin Pharmacokin 3: 337-351
8. Steinijans VW, Hartmann M, Hubert R, Radtke HW 1991 Lack of pharmacokinetic interaction as an equivalence problem. Int J Clin Pharmacol Ther Toxicol 29: 323-328
9. Tedeschi G, Cenraud B, Guyot M, Gomeni R, Morselli PL, Levy RH, Loiseau P 1981 Influence of food on carbamazepine absorption. In: Dam M, Gram L, Penry JK (eds) Advances in Epileptology: XIIth Epilepsy International Symposium. Raven Press, New York, pp 563-567