Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

Aging Clinical and Experimental Research

Volumn 16, Issue 2, 2004, Pages 169-171

  Gangemi, Sebastiano ^a   Basile, Giorgio ^a   Merendino, Rosaria Alba ^a   Balbo, Claudia Lo ^a   Mento, Antonella ^a   Nicita Mauro, Vittorio ^a   Franceschi, Claudio ^b   Romano, Mario ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b INRCA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

Aging; Centenarians; Platelet; QT dispersion

Indexed keywords

AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; ELECTROCARDIOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; ITALY; LONGEVITY; MALE; QT DISPERSION; RISK ASSESSMENT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THROMBOCYTE COUNT;

EID: 2642565211     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324547     Document Type: Article

References (16)

1. Mecocci P, Polidori MC, Troiano L, et al. Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med 2000; 28: 1243-8.
2. Mari D, Mannucci PM, Coppola R, Bottasso B, Bauer KA, Rosenberg RD. Hypercoagulability in centenarians: The paradox of successful aging. Blood 1995; 85: 3144-9.
3. Baggio G, Donazzan S, Monti D, et al. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factor. FASEB J 1998; 12: 433-7.
4. Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 936-8.
5. Day CP, McComb JM, Campbell RWF. QT dispersion: an indication of arrhythmia risk in patients with long QT interval. Br Heart J 1990; 63: 342-4.
6. Perkiomaki JS, Sourander LB, Levomaki L, Rahia IJ, Puukka P, Huikuri HV. QT dispersion and mortality in the elderly. Ann Non-ivasive Electrocardiol 2001; 6: 183-92.
7. Veglio M, Giunti S, Stevens LK, Fuller JH, Perin PC, EURODIAB IDDM Complications Study Group. Prevalence of Q-T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: the EURODIAB IDDM Complications Study Group. Diabetes Care 2002; 25: 702-7.
8. Reardon M, Malik M. QT interval change with age in an overtly healthy older population. Clin Cardiol 1996; 19: 949-52.
9. Mangoni AA, Kinirons MT, Swift CG, Jackson SHD. Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis. Age Ageing 2003; 32: 326-31.
10. Franceschi C, Motta L, Valensin R, et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging Clin Exp Res 2000; 12: 77-84.
11. Woosley RL, Sale M. QT interval: a measure of drug action. Am J Cardiol 1993; 72: 36B-43B.
12. Washizuka T, Aizawa Y, Fuse I, Shibata A. Abnormal function of platelet G proteins in long QT syndrome. Jpn Heart J 1996; 37: 85-93.
13. Piccirillo G, Cacciafesta M, Lionetti M, et al. Influence of age, the autonomic nervous system and anxiety on QT-interval variability. Clin Sci 2001; 101: 429-38.
14. Freden K, Lundborg P, Vilen L, Kutti J. The peripheral platelet count in response to adrenergic alpha- and beta-1-receptor stimulation. Scand J Haematol 1978; 21: 427-32.
15. Rabini RA, Vignini A, Martarelli D, et al. Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians. Exp Gerontol 2003; 38: 367-71.
16. Hoffman BF, Guo SD, Feinmark SJ. Arrhythmias caused by platelet activating factor. J Cardiovasc Electrophysiol 1996; 7: 120-33.