Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid

Modern Pathology

Volumn 17, Issue 6, 2004, Pages 631-636

  Hirsch, Michelle S ^a   Faquin, William C ^b   Krane, Jeffrey F ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Calcitonin; Carcinoid; Larynx; Medullary; Neuroendocrine; p53; Thyroid; TTF 1

Indexed keywords

CALCITONIN; PROTEIN P53; THYROID TRANSCRIPTION FACTOR 1;

ADULT; AGED; ARTICLE; CALCITONIN BLOOD LEVEL; CLINICAL ARTICLE; DIFFERENTIAL DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LARYNX CARCINOMA; MALE; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; RELIABILITY; THYROID MEDULLARY CARCINOMA;

ADULT; AGED; CALCITONIN; CARCINOMA, MEDULLARY; CARCINOMA, NEUROENDOCRINE; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; THYROID GLAND; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2642546611     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800105     Document Type: Article

References (26)

1. Woodruff JM, Senie RT. Atypical carcinoid tumor of the larynx: a critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:194-209.
2. Mills SE. Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 2002;15:264-278.
3. Woodruff JM, Huvos AG, Erlandson RA, et al. Neuroendocrine carcinomas of the larynx. Am J Surg Pathol 1985;9:771-790.
4. Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx. Cancer 1988;62:2658-2676.
5. McCluggage WG. Atypical carcinoid tumor of the larynx: an immunohistochemical, ultrastructural, and flow cytometric analysis. Ultrastruct Pathol 1997;21:431-438.
6. Ferlito A, Barnes L, Rinaldo A, et al. A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol 1998;112:827-834.
7. Guazzi S, Price M, de Felice M, et al. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J 1990;9:3631-3639.
8. Lazzaro D, Price M, de Felice M, et al. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 1991;113:1093-1104.
9. Folpe AL, Gown Am, Lamps LW, et al. Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. Mod Pathol 1999;12:5-8.
10. Katoh R, Miyagi E, Nakamura N, et al. Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas. Hum Pathol 2000;31:386-393.
11. Kaufmann O, Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology 2000;36:415-420.
12. Oliveira AM, Tazelaar HD, Myers JL, et al. Thyroid transcription factor-1 distinguishes metastatic pulmonary from well-differentiated neuroendocrine tumors of other sites. Am J Surg Pathol 2001;25:815-819.
13. Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 2000;13:238-242.
14. Goldman NC, Hood CI, Singleton GT. Carcinoid of the larynx. Arch Otolaryngol 1969;90:91-93.
15. Olofsson J, van Nostrand AWP. Anaplastic small cell carcinoma of the larynx. Case report. Ann Otol Rhinol Laryngol 1972;81:284-287.
16. Markel SF, Magielski JE, Beals TF. Carcinoid tumor of the larynx. Arch Otolaryngol 1980;106:777-778.
17. Ferlito A. The World Health Organization's revised classification of tumors of the larynx, hypopharynx, and trachea. Ann Otol Rhinol Laryngol 1993;102:666-669.
18. Mills SE. Neuroendocrine tumors of the head and neck: a selected review with emphasis on terminology. Endocrinol Pathol 1996;7:329-343.
19. Sweeney EC, McDonnell L, O'Brien C. Medullary carcinoma of the thyroid presenting as tumors of the pharynx and larynx. Histopathology 1981;5:263-275.
20. Smets G, Warson F, Dehou M-F, et al. Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma. Virchows Arch 1990;416:539-543.
21. Insabato L, De Rosa G, Terracciano LM, et al. A calcitonin-producing neuroendocrine tumor of the larynx: a case report. Tumori 1993;79:227-230.
22. Holm R, Nesland JM. Retinoblastoma and p53 tumor suppressor gene protein expression in carcinomas of the thyroid gland. J Pathol 1994;172:267-272.
23. Wang DG, Johnston CF, Anderson N, et al. Overexpression of the tumor suppressor gene p53 is not implicated in neuroendocrine carcinogenesis. J Pathol 1995;175:397-401.
24. Pelosi G, Fraggetta F, Pasini F, et al. Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. Am J Surg Pathol 2001;25:363-372.
25. Yatabe Y, Mitsudomi T, Takahashi T. TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol 2002;26:767-773.
26. Wu M, Wang B, Gil J, et al. p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung. Am J Clin Pathol 2003;119:696-702.