Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study

Pigment Cell Research

Volumn 17, Issue 3, 2004, Pages 270-274

  De Vijlder, Hannah C ^a   Westerhof, Wiete ^a,c   Schreuder, Geziena M Th ^b   De Lange, Peter ^b   Claas, Frans H J ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Netherlands Institute for Pigment Disorders   (Netherlands)

Author keywords

Association; Genetics; Halo nevi; Human leukocyte antigen; Vitiligo

Indexed keywords

GENOMIC DNA; HLA ANTIGEN; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN; HLA DR11 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HLA DR53 ANTIGEN; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CASE CONTROL STUDY; CAUCASIAN; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; DOT HYBRIDIZATION; FAMILY; FEMALE; HALO NEVUS ASSOCIATED WITH VITILIGO; HLA SYSTEM; HLA TYPING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NEVUS; OUTCOMES RESEARCH; PATHOGENESIS; POLYMERASE CHAIN REACTION; RISK FACTOR; VITILIGO; VITILIGO VULGARIS;

ADOLESCENT; ADULT; AGED; ALLELES; COMORBIDITY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENES, MHC CLASS II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTOCOMPATIBILITY TESTING; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; NEVUS, PIGMENTED; ODDS RATIO; VITILIGO;

EID: 2642539088     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.2004.00145.x     Document Type: Article

References (28)

1. Ortonne JP, Mosher DB, Fitzpatrick TB, eds. Vitiligo in: Vitiligo and Other Hypomelanosis of Hair and Skin. New York: Plenum Medical Book Company; 1983. pp. 129-310
2. Westerhof W, Bolhaar B, Menke HE, Harper JL. Resultaten van een enquête onder vitiligo patiënten. Ned Tijdschr Dermatol en venereol 1996;6:100-105
3. Nath SK, Majumder PP, Nordlund JJ. Genetic epidemiology of vitiligo: multilocus recessivity cross-validated. Am J Hum Gen 1994;55:981-990
4. Fain PR, Gowan K, LaBerge GS, Alkhateeb A, Stetler GL, Talbert J, Bennett DC, Spritz RA. A genomewide screen for generalized vitiligo: confirmation of AIS1 on chromosome 1p31 and evidence for additional susceptibility loci. Am J Hum Genet 2003;72:1560-1564
5. Foley LM, Lowe NJ, Misheloff E, Tiwari JL. Association of HLA DR4 with vitiligo. J Am Acad Dermatol 1983;8:39-40
6. Dunston GM, Halder RM. Vitiligo is associated with HLA-DR4 in black patients. Arch Dermatol 1990;126:56-60
7. Venneker GT, de Waal LP, Westerhof W, D'Amaro J, Schreuder GMT, Asghar SS. HLA associations in vitiligo patients in the Dutch population. Dis Markers 1983;11:187-190
8. Venneker GT, Westerhof W, de Vries IJ. Molecular heterogeneity of the fourth component of complement (C4) and its genes in vitiligo. J Invest Dermatol 1992;99:853-858
9. Zamani M, Spaepen M, Asghar SS et al. Linkage and association of HLA class II genes with vitiligo in a Dutch population. Br J Med 2001;145:90-94
10. Schallreuter KU, Levening C, Kuhnl P, Loliger C, Hohl-Tehari M, Berger J. Histocompatibility antigens in vitiligo: Hamburg study on 102 patients from northern Germany. Dermatology 1993;187:186-192
11. Poloy A, Tibor L, Kramer R et al. HLA DRI is associated with vitiligo. Immunol Lett 1991;27:59-62
12. Buc M, Busova B, Hegyi E, Kolibasova K. Vitiligo is associated with HLA-A2 and HLA-DW7 in the slovak populations. Folia Biol (Praha) 1996;42:23-25
13. Buc M, Fazekasova H, Cechova E, Hegyi E, Kolibasova K, Ferencik S. Occurrence rates of HLA-DRB1, HLA-DQB1 and HLA-DPB1 Alleles in patients suffering from vitiligo. Eur J Dermatol 1998;8:13-15
14. Finco O, Cuccia M, Martinetti M, Ruberto G, Orrechia G, Rabbiosi G. Age of onset in vitiligo: relationship with HLA supratypes. Clin Genet 1991;39:48-54
15. Orecchia G, Perfetti L, Malagoli P Borghini F, Kipervarg Y. Vitiligo is associated with significant increase in HLA-A30, CW6, DQwr and a decrease in C4AQO in northern Italian patients. Dermatology 1992;185:123-127
16. Ventakaram MN, White AG, Leeny WA, Al Suwaid AR, Daar AS. HLA antigens in Omani patients with vitiligo. Clin Exp Dermatol 1995;20:35-37
17. Al-Fouzan A, al-Arbash M, Fouad F, Kaaba SA, Mousa MA, al-Harbi SA. Study of HLA class I/II and T lymphocyte subsets in Kuwaiti vitiligo patients. Eur J Immunogenet 1995;22:209-213
18. Schipper RF, Schreuder GMT, D'Amaro J, Oudshoorn M. HLA gene and haplotype frequencies in Dutch blood donors. Tissue Antigens 1996;48:562-574
19. Verduyn W, Doxiadis IIN, D'Amaro J, Persijn G, Giphart MJ, Schreuder GMT. Biotinylated DRB SSO: comparison to serologic HLA-DR typing of organ donors in eurotransplant. Human Immunol 1993;37:59-67
20. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet 1955;19:251-253
21. Haldane JBS. The estimation and significance of the logarithm of a ratio of frequencies. Ann Hum Genet 1955;20:309-311
22. Edwards J. HLA and disease. The detection of associations. J Immunogenet 1974;1:249
23. Ongenae K, van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res 2003;16:90-100
24. Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol 1997;37:620-624
25. Baranda L, Torres-Alvarez B, Moncada B, Portales-Perez D, de la Fuente H, Layseca E, Gonzalez-Amaro R. Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. J Am Acad Dermatol 1999;41:567-572
26. Musette P, Bachelez H, Flageul B, Delarbre C, Kourilsky P, Dubertret L, Gachelin G. Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. J Immunol 1999;162:1789-1794
27. Bergman W, Willemze R, de Graaff-Reitsma C, Ruiter DJ. Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. J Invest Dermatol 1985;85:25-29
28. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res 2003;16:208-214