Efavirenz-associated gynecomastia: Report of five cases and review of the literature

Breast Journal

Volumn 10, Issue 3, 2004, Pages 244-246

  Jover, Francisco ^a,b   Cuadrado, José M ^a   Roig, Pablo ^a   Rodríguez, Marta ^a   Andreu, Lucio ^a   Merino, Jaime ^a  

^a HOSPITAL UNIVERSITARIO DE SAN JUAN   (Spain)

^b NONE   (Spain)

Author keywords

Antiretroviral drug; Efavirenz; Gynecomastia; Human immunodeficiency virus

Indexed keywords

ABACAVIR; DIDANOSINE; EFAVIRENZ; ESTRADIOL; INDINAVIR; LAMIVUDINE; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ADIPOSE TISSUE; ADULT; BREAST LESION; CLINICAL ARTICLE; DRUG EFFECT; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GYNECOMASTIA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LIPOMASTIA; LONGITUDINAL STUDY; MALE; PATHOGENESIS; PROGNOSIS; REVIEW;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; GYNECOMASTIA; HIV INFECTIONS; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OXAZINES; REVERSE TRANSCRIPTASE INHIBITORS; RISK FACTORS; TIME FACTORS;

EID: 2642534354     PISSN: 1075122X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1075-122X.2004.21392.x     Document Type: Review

References (13)

1. Pantanowitz L, Connolly J. Pathology of the breast associated with HIV/AIDS. Breast J 2002;8:234-43.
2. Couderc LJ, Clauvet JP. HIV infection-induced gynecomastia. Ann Intern Med 1987;107:257.
3. Peyriere H, Mauboussin JM, Rouanet I, et al. Report of gynecomastia in five male patients during antiretroviral therapy for HIV infection. AIDS 1999;13:2167-91.
4. Donovan B, Bodsworth NJ, Mulhall B, Allen D. Gynecomastia associated with saquinavir therapy. Int J STD AIDS 1999;10:49-50.
5. Piroth L, Grappin M, Petit JM, Buisson M, Duong M, Chavanet P. Incidence of gynecomastia in men infected with HIV and treated with highly active antiretroviral therapy. Scand J Infect Dis 2001;33:559-60.
6. Mercie P, Viallard JF, Rodolphe T, et al. Efavirenz-associated breast hypertrophy in HIV-infected patients. AIDS 2001;15:126-28.
7. Caso JA, Prieto JM, Casas E, Sanz J. Gynecomastia without lipodystrophy syndrome in HIV-infected men treated with efavirenz. AIDS 2001;15:1447-52.
8. Qazi NA, Morlese JF, King DM, Ahmad RS, Gazzard BG, Nelson MR. Gynecomastia without lipodystrophy in HIV-1 seropositive patients on efavirenz: an alternative hypothesis. AIDS 2002;16:506-7.
9. Evans DL, Pantanowitz L, Dezube BJ, Aboulafia DM. Breast enlargement in 13 men who were seropositive for human immunodeficiency virus. Clin Infect Dis 2002;35:1113-19.
10. Qazi NA, Morlese JF, King DM, Ahmad RS, Gazzard BG, Nelson MR. True gynaecomastia, another manifestation of immune reconstitution disease?. Int J STD AIDS 2002;13:59-65.
11. Toma E, Therrien R. Gynecomastia during indinavir antiretroviral therapy in HIV infection. AIDS 1998;12:681-82.
12. DuPont Pharmaceutical company. Sustiva. Document 6495-00. Wilmington, DE: DuPont Pharmaceutical, 1998.
13. Sinicco A, Raiteri R, Rossati A, Savarino A, Di Perri G. Efavirenz interference in estradiol ELISA assay. Clin Chem 2000;46:734-35.