Higher metal-ligand coordination in the catalytic site of cobalt-substituted Thermoanaerobacter brockii alcohol dehydrogenase lowers the barrier for enzyme catalysis

Biochemistry

Volumn 43, Issue 22, 2004, Pages 7151-7161

  Kleifeld, Oded ^a   Rulíšek, Lubomír ^b   Bogin, Oren ^a   Frenkel, Anatoly ^c   Havlas, Zdeněk ^b   Burstein, Yigal ^a   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c YESHIVA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOCHEMISTRY; CATALYSIS; ENZYMES; OXIDATION; STRUCTURE (COMPOSITION); X RAY ANALYSIS;

ENZYME CATALYSIS; METAL-LIGAND COORDINATION;

COBALT;

ALCOHOL DEHYDROGENASE; BACTERIAL ENZYME; COBALT; LIGAND; METAL; RECOMBINANT ENZYME;

ARTICLE; ATOMIC EMISSION SPECTROMETRY; BACTERIUM; CATALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ESCHERICHIA COLI; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTUM CHEMISTRY; THERMOANAEROBACTER BROCKII;

ALCOHOL DEHYDROGENASE; BACTERIA, ANAEROBIC; CATALYSIS; CATALYTIC DOMAIN; COBALT; CRYSTALLOGRAPHY, X-RAY; LIGANDS; WATER; ZINC;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; THERMOANAEROBACTER; THERMOANAEROBACTER BROCKII;

EID: 2642532798     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0302696     Document Type: Article

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