Prognostic value of myocardial salvage achieved by reperfusion therapy in patients with acute myocardial infarction

Journal of Nuclear Medicine

Volumn 45, Issue 5, 2004, Pages 725-729

  Ndrepepa, Gjin ^a   Mehilli, Julinda ^a   Schwaiger, Markus ^a   Schühlen, Helmut ^b   Nekolla, Stephan ^a   Martinoff, Stefan ^a   Schmitt, Claus ^a   Dirschinger, Josef ^b   Schömig, Albert ^a,b   Kastrati, Adnan ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acute myocardial infarction; Prognosis; Reperfusion; Scintigraphy; Stents; Thrombolysis

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ALTEPLASE; HEPARIN; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ACUTE HEART INFARCTION; ARTICLE; BLOOD CLOT LYSIS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY STENT; FEMALE; FOLLOW UP; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART SCINTISCANNING; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME; ELECTROCARDIOGRAPHY; FIBRINOLYTIC THERAPY; HEART; HEART INFARCTION; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STENT; SURVIVAL; TIME;

ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOPHARMACEUTICALS; STENTS; SURVIVAL ANALYSIS; TECHNETIUM TC 99M SESTAMIBI; THROMBOLYTIC THERAPY; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 2642524611     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI). Lancet. 1986;1:397-402.
2. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet. 1988;2:349-360.
3. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators. N Engl J Med. 1993;329:673-682.
4. Gibbons RJ, Miller TD, Christian TF. Infarct size measured by single photon emission computed tomographic imaging with 99m Tc-sestamibi: a measure of the efficacy of therapy in acute myocardial infarction. Circulation. 2000;101:101-108.
5. Pepine CJ. Prognostic markers in thrombolytic therapy: looking beyond mortality. Am J Cardiol. 1996;78(suppl 12A):24-27.
6. Braunwald E. Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction, and improved survival: should the paradigm be expanded? Circulation. 1989;79:441-444.
7. Schömig A, Kastrati A, Dirschinger J, et al. Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. N Engl J Med. 2000;343:385-391.
8. Kastrati A, Mehilli J, Dirschinger J, et al. Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial. Lancet. 2002;359:920-925.
9. Kastrati A, Mehilli J, Nekolla S, et al. A randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy. J Am Coll Cardiol. 2004;43:734-741.
10. Verani MS, Jeroudi MO, Mahmarian JJ, et al. Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol. 1988;12:1573-1581.
11. 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation. 1989;80:1277-1286.
12. Wackers FJ, Gibbons RJ, Verani MS, et al. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: efficacy for noninvasive assessment of thrombolytic therapy. J Am Coll Cardiol. 1989;14:861-873.
13. Pellikka PA, Behrenbeck T, Verani MS, Mahmarian JJ, Wackers FJ, Gibbons RJ. Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction. J Nucl Med. 1990;31:1269-1275.
14. Sinusas AJ, Trautman KA, Bergin JD, et al. Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile. Circulation. 1990;82:1424-1437.
15. De Coster PM, Wijns W, Cauwe F, Robert A, Beckers C, Melin JA. Area-at-risk determination by technetium-99m-hexakis-2-methoxyisobutyl isonitrile in experimental reperfused myocardial infarction. Circulation. 1990;82:2152-2162.
16. 99mTc sestamibi in patients undergoing cardiac transplantation: a scintigraphic/pathological study. Circulation. 1996;94:1010-1017.
17. 99mTc sestamibi imaging predicts subsequent mortality. Circulation. 1995;92:334-341.
18. Miller TD, Hodge DO, Sutton JM, et al. Usefulness of technetium-99m sestamibi infarct size in predicting posthospital mortality following acute myocardial infarction. Am J Cardiol. 1998;81:1491-1493.
19. Burns RJ, Gibbons RJ, Yi Q, et al. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. CORE Study Investigators. J Am Coll Cardiol. 2002;39:30-36.
20. Christian TF, Schwartz RS, Gibbons RJ. Determinants of infarct size in reperfusion therapy for acute myocardial infarction. Circulation. 1992;86:81-90.
21. Reimer KA, Jennings RB, Cobb FR, et al. Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study - comparison of unconscious and conscious dog models. Circ Res. 1985;56:651-665.
22. Milavetz JJ, Giebel DW, Christian TF, Schwartz RS, Holmes DR Jr, Gibbons RJ. Time to therapy and salvage in myocardial infarction. J Am Coll Cardiol. 1998;31:1246-1251.
23. Laster SB, O'Keefe JH Jr, Gibbons RJ. Incidence and importance of thrombolysis in myocardial infarction grade 3 flow after primary percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol. 1996;78:623-626.
24. Dibra A, Mehilli J, Dirschinger J, et al. Thrombolysis in myocardial infarction myocardial perfusion grade in angiography correlates with myocardial salvage in patients with acute myocardial infarction treated with stenting or thrombolysis. J Am Coll Cardiol. 2003;41:925-929.
25. Dong J, Ndrepepa G, Schmitt C, et al. Early resolution of ST-segment elevation correlates with myocardial salvage assessed by Tc-99m sestamibi scintigraphy in patients with acute myocardial infarction after mechanical or thrombolytic reperfusion therapy. Circulation. 2002;105:2946-2949.
26. Schömig A, Ndrepepa G, Mehilli J, et al. Dependent influence of time-to-treatment interval on myocardial salvage in patients with acute myocardial infarction treated with coronary artery stenting or thrombolysis. Circulation. 2003;108:1084-1088.