Improved synthesis of functionalized 5,6-dihydro-pyrimido[4,5-b][1,4] oxazepines

Tetrahedron Letters

Volumn 46, Issue 44, 2005, Pages 7523-7526

  Xu, Yong Jiang ^a   Liu, Hu ^a   Pan, Weitao ^a   Chen, Xin ^a   Wong, Wai C ^a   Labelle, Marc ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Oxazepines; Reductive amination

Indexed keywords

ANILINE DERIVATIVE; OXAZEPINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SALICYLALDEHYDE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 26244453587     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.08.161     Document Type: Article

References (14)

1. Smith, L. M., II; Hadari, Y. Patent WO 2005009384, 2005.
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4. Duncton, M. A. J.; Smith, L. M., II; Burdzovic-Wizeman, S.; Burns, A.; Liu, H.; Mao, Y. J. Org. Chem., in press.
5. For biological results on compounds prepared in this study, please refer to Pan, W.; Liu, H.; Xu, Y.-J.; Chen, X.; Milligan, D. L.; Columbus, J.; Balagtas, C.; Hadari, Y.; Wong, W. C.; Kim, K. H.; Labelle, M. Bioorg. Med. Chem. Lett., in press.
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13. 3: C, 62.58; H, 4.34; N, 22.21. Found: C, 62.33; H, 4.10; N, 22.29.
14. 2) afforded 15e (46 mg, 66%) as a white solid with spectroscopic properties identical to those obtained from the reductive amination procedure.