Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury

Journal of Cardiovascular Pharmacology

Volumn 46, Issue 4, 2005, Pages 487-493

  Takahashi, Hiroki ^a   Takeishi, Yasuchika ^a   Arimoto, Takanori ^a   Shishido, Tetsuro ^a   Konta, Tsuneo ^a   Koyama, Yo ^a   Niizeki, Takeshi ^a   Kubota, Isao ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Cardiac hypertrophy; ERK; Pitavastatin; Renal failure; Signal transduction

Indexed keywords

ANGIOTENSIN; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NATRIURETIC FACTOR; PITAVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE COURSE; DNA BINDING; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IN VIVO STUDY; KIDNEY INJURY; MALE; MORTALITY; NEPHRECTOMY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RISK FACTOR; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; ANIMALS, NEWBORN; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; CARDIOMEGALY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; KIDNEY; MALE; MYOCYTES, CARDIAC; NEPHRECTOMY; PHOSPHORYLATION; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASOCONSTRICTOR AGENTS;

EID: 26044483541     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000177984.76186.70     Document Type: Article

References (25)

1. Sadoshima J, Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 1997;59:551-571.
2. Hoshijima M, Sah VP, Brown JH, et al. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem. 1998;273:7725-7730.
3. Bueno OF, Molkentin JD. Involvement of extracellular signal-regulated kinase 1/2 in cardiac hypertrophy and cell death. Circ Res. 2002;91:776-781.
4. Gillespie-Brown J, Fuller SJ, Sugden PH, et al. The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes. J Biol Chem. 1995;270:28092-28096.
5. Babu GJ, Lalli MJ, Periasamy M, et al. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol. 2000;32:1447-1457.
6. Sprenkle AB, Murray SF, Glembotski CC. Involvement of multiple cis elements in basal- and a-adrenergic agonist-inducible atrial natriuretic factor transcription. Roles for serum response elements and an SP-1-like element. Circ Res. 1995;77:1060-1069.
7. Chien KR, Knowlton KU, Chien S, et al. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiolosic response. FASEB J. 1991;5:3037-3046.
8. Foley RN, Parfrey PS, Barre PE, et al. Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int. 1995;47:186-192.
9. Levin A, Foley RN. Cardiovascular disease in chronic renal insufficiency. Am J Kidney Dis. 2000;36:24-30.
10. Foley RN, Parfrey PS, Barre PE, et al. The prognostic importance of left ventricular geometry in uremic cardiomyopathy. J Am Soc Nephrol. 1995;5:2024-2031.
11. Levy D, Garrison RJ, Castelli WP, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-1566.
12. Takahashi H, Takeishi Y, Kubota I, et al. Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury. Eur J Clin Invest. 2004;34:85-93.
13. Luo JD, Xie F, Chen X, et al. Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. Br J Pharmacol. 2001;132:159-164.
14. Oi S, Haneda T, Kikuchi K, et al. Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells. Eur J Pharmacol. 1999;376:139-148.
15. ras activation. Circulation. 2002;106:2118-2124.
16. Takeishi Y, Bhagwat A, Walsh RA, et al. Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure. Am J Physiol. 1999;276:53-62.
17. Takahashi H, Takeishi Y, Kubota I, et al. Adenovirus-mediated overexpression of diacylglycerol kinase ζ inhibits endothelin-1-induced cardiomyocyte hypertrophy. Circulation. 2005;111:1510-1516.
18. Shishido T, Nozaki N, Kubota I, et al. Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation. 2003;108:2905-2910.
19. Sadoshima J, Izumo S. Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res. 1993;73:424-438.
20. Scheuer DA, Thrasher TN, Ramsay DJ, et al. Atrial natriuretic peptide blocks renin response to renal hypotension. Am J Physiol. 1987;252: R423-R427.
21. Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest. 1996;98:1063-1068.
22. Takemoto M, Node K, Liao JK, et al. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest. 2001;108:1429-1437.
23. Hayashidani S, Tsutsui H, Takeshita A, et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 2002;105:868-873.
24. Masamura K, Oida K, Miyamori I, et al. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. Arterioscler Thromb Vasc Biol. 2003;23:512-517.
25. Clerk A, Sugden PH. Small guanine nucleotide-binding proteins and myocardial hypertrophy. Circ Res. 2000;86:1019-1023.