Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years

International Journal of Cardiology

Volumn 105, Issue 1, 2005, Pages 90-95

  Ortlepp, Jan R ^a   Krantz, Constanze ^a   Kimmel, Melanie ^a   Von Korff, Alexei ^a   Vesper, Katharina ^a   Schmitz, Fabian ^a   Mevissen, Vera ^a   Janssens, Uwe ^a   Franke, Andreas ^a   Hanrath, Peter ^a   Zerres, Klaus ^a   Hoffmann, Rainer ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Cardiovascular risk factors; Genetic polymorphism; Genetic risk factors; Myocardial infarction

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 6; VITAMIN D RECEPTOR;

ADULT; AGE; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HEART CINEVENTRICULOGRAPHY; HEART FUNCTION; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SMOKING;

AGE FACTORS; AGED; CARDIOVASCULAR DISEASES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL; RECEPTORS, CHEMOKINE; RISK FACTORS;

EID: 26044482278     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.03.004     Document Type: Article

References (23)

1. W.B. Kannel, T.R. Dawber, and A. Kagan Factors of risk in the development of coronary heart disease-six year follow up experience: the Framingham study Ann Intern Med 55 1961 33 50
2. W.B. Kannel, and P.W. Wilson An update on coronary risk factors Med Clin North Am 79 1995 951 971
3. G.E. Fraser, T.M. Strahan, J. Sabate, W.L. Beeson, and D. Kissinger Effects of traditional coronary risk factors on rates of incident coronary events in a low-risk population Circulation 86 1992 406 413
4. M.E. Marenberg, N. Risch, L.F. Berkman, B. Floderus, and U. de Faire Genetic susceptibility to death from coronary heart disease in a study of twins N Engl J Med 330 1994 1041 1046
5. J.R. Ortlepp, U. Janssens, J. Lauscher, R. Hoffmann, and P. Hanrath Analysis of multiple genetic polymorphisms improves assessment of the individual genetic burden for coronary artery disease Eur J Intern Med 13 2002 485 492
6. R. Ross The pathogenesis of atherosclerosis-an update N Engl J Med 314 1986 488 500
7. C. Weber Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules J Mol Med 81 2003 4 19
8. M.W. Smith, M. Dean, and M. Carrington Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study Science 277 1997 959 965
9. 3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase Circ Res 91 2002 17 24
10. N.A. Morrison, J.C. Qi, A. Tokita, P.J. Kelly, L. Crofts, and T.V. Nguyen Prediction of bone density from vitamin D receptor alleles Nature 367 1994 284 287
11. J.R. Ortlepp, J. Metrikat, M. Albrecht, A. von Korff, and R. Hoffman The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men Diabet Med 20 2003 451 454
12. L.M. Biasucci, A. Vitelli, and G. Liuzzi Elevated levels of IL-6 in unstable angina Circulation 94 1996 874 877
13. C.U. Chae, R.T. Lee, N. Rifai, and P.M. Ridker Blood pressure and inflammation in apparently healthy men Hypertension 38 2001 399 403
14. D.J. Brull, H.E. Montgomery, J. Sanders, S. Dhamrait, L. Luong, and A. Rumley Interleukin-6 Gene-174G>C and-572G>C promoter polymorphism are strong predictors of plasma interleukin-6 Levels after coronary artery bypass surgery Arterioscler Thromb Vasc Biol 21 2001 1458 1463
15. J.R. Ortlepp, J. Metrikat, K. Vesper, V. Mevissen, F. Schmitz, and M. Albrecht The interleukin 6 promoter polymorphism is associated with elevated leukocytes and reduced physical fitness in young healthy smokers J Mol Med 81 2003 578 584
16. K.G. Jones, D.J. Brull, L.C. Brown, M. Sian, R.M. Greenhalgh, and S.E. Humphries Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysm Circulation 103 2001 2260 2265
17. J.R. Ortlepp, A. von Korff, P. Hanrath, K. Zerres, and R. Hoffman The vitamin D receptor gene variant does not predict the prevalence and severity of coronary artery disease in a large scale angiographic cohort of 3441 patients Eur J Clin Invest 33 2003 106 109
18. J.R. Ortlepp, K. Vesper, V. Mevissen, F. Schmitz, U. Janssens, and A. Franke Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age J Mol Med 81 2003 363 367
19. K.J. Livak Allelic discrimination using fluorogenic probes and the 5′ nuclease assay Genet Anal 14 1999 143 149
20. F. Cambien, O. Poirier, L. Lecerf, A. Evans, J.P. Cambou, and D. Arveiler Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction Nature 359 1992 641 644
21. B. Keavney, C. McKenzie, S. Parish, A. Palmer, S. Clark, and L. Youngman Large-scale test of hypothesised associations between the angiotensin- converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls Lancet 355 2000 434 442
22. U. Broeckel, C. Hengstenberg, B. Mayer, S. Holmer, L.J. Martin, and A.G. Comuzzie A comprehensive linkage for myocardial infarction and its related risk factors Nat Genet 30 2002 210 214
23. Y. Yamada, H. Izawa, S. Ichihara, F. Takatsu, H. Ishihara, and H. Hirayama Prediction of the risk of myocardial infarction from polymorphisms in candidate genes N Engl J Med 347 2002 1916 1923