Colonic blood flow responses in experimental colitis: Time course and underlying mechanisms

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 289, Issue 6 52-6, 2005, Pages

  Mori, Mikiji ^a   Stokes, Karen Y ^a   Vowinkel, Thorsten ^a   Watanabe, Naoyuki ^a   Elrod, John W ^a   Harris, Norman R ^a   Lefer, David J ^a   Hibi, Toshifumi ^b   Granger, D Neil ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Arterioles; Colon; Endothelium dependent vasodilation; NAD(P)H oxidase; Superoxide

Indexed keywords

BRADYKININ; COPPER ZINC SUPEROXIDE DISMUTASE; DEXTRAN SULFATE; GLYCOPROTEIN GP 91; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTERY DIAMETER; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; CHRONIC INFLAMMATION; COLITIS; COLON BLOOD FLOW; CONTROLLED STUDY; ENZYME SUBUNIT; HEART OUTPUT; INTESTINE BLOOD FLOW; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBMUCOSA; TISSUE PERFUSION;

ANIMALS; ARTERIOLES; BRADYKININ; COLITIS; COLON; DEPRESSION, CHEMICAL; DEXTRAN SULFATE; HEART RATE; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; PAPAVERINE; REGIONAL BLOOD FLOW; VASODILATION;

EID: 26044451963     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00247.2005     Document Type: Article

References (31)

1. Appleyard CB, Williams JL, Hathaway CA, and Percy WH. Temporal patterns of colonic blood flow and tissue damage in an animal model of colitis. Dig Dis Sci 44: 431-438, 1999.
2. Banda MA, Lefer DJ, and Granger DN. Postischemic endothelium-dependent vascular reactivity is preserved in adhesion molecule-deficient mice. Am J Physiol Heart Circ Physiol 273: H2721-H2725, 1997.
3. Bolondi L, Gaiani S, Brignola C, Campieri M, Rigamonti A, Zironi G, Gionchetti P, Belloli C, Miglioli M, and Barbara L. Changes in splanchnic hemodynamics in inflammatory bowel disease. Non-invasive assessment by Doppler ultrasound flowmetry. Scand J Gastroenterol 27: 501-507, 1992.
4. Deniz M, Cetinel S, and Kurtel H. Blood flow alterations in TNBS-induced colitis: role of endothelin receptors, Inflamm Res 53: 329-336, 2004.
5. Ebaugh FG. Quantitative measurement of gastrointestinal blood loss. J Lab Clin Med 53: 77-82, 1959.
6. Foitzik T, Kruschewski M, Kroesen A, and Buhr HJ. Does microcirculation play a role in the pathogenesis of inflammatory bowel diseases? Answers from intravital microscopic studies in animal models. Int J Colorectal Dis 14: 29-34, 1999.
7. Garrelds IM, Heiligers JP, Van Meeteren ME, Duncker DJ, Saxena PR, Meijssen MA, and Zijlstra FJ. Intestinal blood flow in murine colitis induced with dextran sulfate sodium. Dig Dis Sci 47: 2231-2236, 2002.
8. Gorlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, and Busse R. A gp9lphox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87: 26-32, 2000.
9. Granger DN, Grisham MB, and Kvietys PR. Mechanisms of microvascular injury. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR. New York: Raven Press, 1994, p. 1693-1722.
10. Griendling KK, Sorescu D, and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000.
11. Guslandi M, Polli D, Sorghi M, and Tittobello A. Rectal blood flow in ulcerative colitis. Am J Gastroenterol 90: 579-580, 1995.
12. Guzik TJ, West NE, Black E, McDonald D, Ratnatunga C, Pillai R, and Channon KM. Vascular Superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors. Circ Res 86: E85-E90, 2000.
13. Hatoum OA, Binion DG, Otterson MF, and Gutterman DD. Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 125: 58-69, 2003.
14. Hatoum OA, Miura H, and Binion DG. The vascular contribution in the pathogenesis of inflammatory bowel disease. Am J Physiol Heart Circ Physiol 285: H1791-H1796, 2003.
15. Hayashi K, Kanda T, Homma K, Tokuyama H, Okubo K, Takamatsu I, Tatematsu S, Kumagai H, and Saruta T. Altered renal microvascular response in Zucker obese rats. Metabolism 51: 1553-1561, 2002.
16. Hulten L, Lindhagen J, Lundgren O, Fasth S, and Ahren C. Regional intestinal blood flow in ulcerative colitis and Crohn's disease. Gastroenterology 72: 388-396, 1977.
17. Johnson FK, Johnson RA, Peyton KJ, and Durante W. Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension. Am J Physiol Regul Integr Comp Physiol 288: R1057-R1062, 2005.
18. Jones SP, Trocha SD, and Lefer DJ. Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion. Arterioscler Thromb Vasc Biol 21: 2059-2064, 2001.
19. Korthuis RJ. Inflammatory bowel disease: role of the intestinal circulation. In: Pathophysiology of the Splanchic Circulation, edited by Kvietys PR, Barrowman JA, and Granger DN. Boca Raton, FL: CRC, 1987, vol. II, p. 67-88.
20. Krieglstein CF, Cerwinka WH, Laroux FS, Salter JW, Russell JM, Schuermann G, Grisham MB, Ross CR, and Granger DN. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of Superoxide and nitric oxide. J Exp Med 194: 1207-1218, 2001.
21. Kruschewski M, Foitzik T, Perez-Canto A, Hubotter A, and Buhr HJ. Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system. Dig Dis Sci 46: 2336-2343, 2001.
22. Kuo L, Davis MJ, Cannon MS, and Chilian WM. Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine. Circ Res 70: 465-476, 1992.
23. Mori M, Salter JW, Vowinkel T, Krieglstein CF, Stokes KY, and Granger DN. Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol 288: G920-G926, 2005.
24. Mugge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD, and Harrison DG. Chronic treatment with polyethylene-glycolated Superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res 69: 1293-1300, 1991.
25. Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, and Sedergran DJ. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci 38: 1722-1734, 1993.
26. Russell J, Cooper D, Tailor A, Stokes KY, and Granger DN. Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets. Am J Physiol Gastrointest Liver Physiol 284: G123-G129, 2003.
27. Satoyoshi K, Akita Y, Nozu F, Yoshikawa N, and Mitamura K. Hemodynamics in the colonic mucosa of rats with dextran sulfate-induced colitis in the early phase. J Gastroenterol 31: 512-517, 1996.
28. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, and Schnittger I. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 2: 358-367, 1989.
29. Schwaninger RM, Sun H, and Mayhan WG. Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats. Life Sci 73: 3415-3425, 2003.
30. Vowinkel T, Kalogeris TJ, Mori M, Krieglstein CF, and Granger DN. Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Dig Dis Sci 49: 556-564, 2004.
31. Yamada T, Specian RD, Granger DN, Gaginella TS, and Grisham MB. Misoprostol attenuates acetic acid-induced increases in mucosal permeability and inflammation: role of blood flow. Am J Physiol Gastro-intest Liver Physiol 261: G332-G339, 1991.