Apolipoprotein A5 gene polymorphism -1131T →C: Association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese

Clinical Chemistry and Laboratory Medicine

Volumn 43, Issue 6, 2005, Pages 607-612

  Yan, Sheng Kai ^a   Cheng, Xin Qi ^a   Song, Yao Hong ^a   Xiao, Xin Hua ^a   Bi, Nan ^b   Chen, Bao Sheng ^b  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Apolipoprotein A5; Chinese; Diabetes mellitus; Polymorphism; Triglyceride

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN A5; APOLIPOPROTEIN B; APOLIPOPROTEIN C2; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; CHOLESTEROL; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; APOA5 PROTEIN, HUMAN; APOLIPOPROTEIN; APOLIPOPROTEIN A;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; CHINA; CORONARY ARTERY DISEASE; DIABETES MELLITUS; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; APOLIPOPROTEINS; APOLIPOPROTEINS A; CASE-CONTROL STUDIES; CHINA; CORONARY DISEASE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIPIDS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 26044451461     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2005.105     Document Type: Article

References (20)

1. Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1999;48:937-42.
2. Ukkola O, Savolainen MJ, Salmela PI, von-Dickhoff K, Kesaniemi YA. DNA polymorphisms at the lipoprotein lipase gene are associated with macroangiopathy in type 2 (non-insulin-dependent) diabetes mellitus. Atherosclerosis 1995;115:99-105.
3. Wilson PW. High-density lipoprotein, low-density lipoprotein and coronary artery disease. Am J Cardiol 1990; 66:7A-10A.
4. Castelli W. Epidemiology of triglyceride: a view from Framingham. Am J Cardiol 1992;70:3H-9H.
5. Alexander CM, Landsman PB, Teutsch SM, Haffner SM. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003; 52:1210-4.
6. Gianturco SH, Bradley WA. Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: cellular aspects. Clin Cardiol 1999;22(Suppl):II7-II14.
7. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 2001;294:169-73.
8. Nabika T, Nasreen S, Kobayashi S, Masuda J. The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. Atherosclerosis 2002;165:201-4.
9. Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet 2002;11:3031-8.
10. Endo K, Yanagi H, Araki J, Hirano C, Yamakawa-Kobayashi K, Tomura S. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum Genet 2002;111:570-2.
11. Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, et al. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. J Lipid Res 2003;44:1167-73.
12. Baum L, Tomlinson B, Thomas GN. APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet 2003;63:377-9.
13. Horinek A, Vrablik M, Ceska R, Adamkova V, Poledne R, Hubacek JA. T-1131→C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. Atherosclerosis 2003;167:369-70.
14. Li GP, Wang JY, Yan SK, Chen BS, Xue H, Wu G. Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population. Clin Genet 2004;65:470-6.
15. West KM, Ahuja MM, Bennett PH, Czyzyk A, De Acosta OM, Fuller JH, et al. The role of circulating glucose and triglyceride concentrations and their interactions with other "risk factors" as determinants of arterial disease in nine diabetic population samples from the WHO mul-tinational study. Diabetes Care 1983; 6:361-9.
16. Szalai C, Keszai M, Duba J, Prohaszka Z, Kozma GT, Csaszar A, et al. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis 2004;173:109-14.
17. WHO. Report of a WHO consultation: definition, diagnosis and classification of diabetes mellitus and its complications. Geneva, Switzerland, 1999.
18. Edwards KL, Mahaney MC, Motulsky AG, Austin MA. Pleiotropic genetic effects on LDL size, plasma triglyceride, and HDL cholesterol in families. Arterioscler Thromb Vasc Biol 1999;19:2456-64.
19. Prieur X, Coste H, Rodriguez JC. The human apolipoprotein AV gene is regulated by peroxisome proliferatoractivated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J Biol Chem 2003;278:25468-80.
20. Evans D, Buchwald A, Beil FU. The single nucleotide polymorphism -1131T→C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia. J Mol Med 2003; 81:645-54.