QT prolongation and syncope with methadone, doxepin, and a β-blocker [5]

Annals of Pharmacotherapy

Volumn 39, Issue 10, 2005, Pages 1762-1763

  Rademacher, Sibylle ^a   Dietz, Rainer ^a   Haverkamp, Wilhelm ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATININE; DOXEPIN; LEVOMETHADONE; MAGNESIUM; METHADONE; METOPROLOL; POTASSIUM;

ADULT; ANXIETY DISORDER; CASE REPORT; CREATININE BLOOD LEVEL; DRUG DEPENDENCE; ELECTROCARDIOGRAM; HUMAN; LETTER; MAGNESIUM BLOOD LEVEL; MALE; METHADONE TREATMENT; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; QT PROLONGATION; SINUS BRADYCARDIA; SYNCOPE; TACHYCARDIA; URINALYSIS; WITHDRAWAL SYNDROME;

ADRENERGIC BETA-ANTAGONISTS; ADULT; ANXIETY DISORDERS; DOXEPIN; ELECTROCARDIOGRAPHY; HUMANS; LONG QT SYNDROME; MALE; METHADONE; SUBSTANCE-RELATED DISORDERS; SYNCOPE; TACHYCARDIA;

EID: 25844529447     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1G277     Document Type: Letter

References (4)

1. Krantz MJ, Lewkowicz L, Hays H, Woodroffe MA, Robertson AD, Mehler PS. Torsade de pointes associated with very-high-dose methadone. Ann Intern Med 2002;137:501-4.
2. Strasberg B, Coelho A, Welch W, Swiryn S, Bauernfeind R, Rosen K. Doxepin induced torsade de pointes. Pacing Clin Electrophysiol 1982; 5:873-7.
3. Haverkamp W, Breithardt G, Camm AJ, Janse MJ, Rosen MR, Antzelevitch C, et al. The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. Cardiovasc Res 2000;47:219-33.
4. Kurita T, Ohe T, Marui N, Aihara N, Takaki H, Kamakura S, et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsade de pointes. Am J Cardiol 1992; 69:628-33.