Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: A randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica

Volumn 84, Issue 10, 2005, Pages 951-955

  Facchinetti, Fabio ^a,d   Casini, Maria Luisa ^b   Costabile, Loredana ^c   Malavasi, Barbara ^a   Unfer, Vittorio ^c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c AGUNCO Obstetrics and Gynecology Centre   (Italy)

^d Dip Materno Infantile   (Italy)

Author keywords

Diclofenac hydroxyethyl pyrrolidine; Episiotomy pain; Ketoprofen; Postpartum analgesia; Vaginal birth

Indexed keywords

DICLOFENAC DERIVATIVE; DICLOFENAC HYDROXYETHYL PYRROLIDINE; KETOPROFEN; MOLFENAC; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; EPISIOTOMY; FEMALE; GASTROINTESTINAL DISEASE; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; NAUSEA; OBSTETRIC ANALGESIA; PAIN ASSESSMENT; PATIENT SATISFACTION; POSTPARTUM PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; STOMACH PAIN; TREATMENT FAILURE; VAGINAL DELIVERY; VERTIGO; VISUAL ANALOG SCALE;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOUBLE-BLIND METHOD; EPISIOTOMY; FEMALE; HUMANS; KETOPROFEN; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PREGNANCY; TREATMENT OUTCOME;

EID: 25844475916     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-6349.2005.00758.x     Document Type: Article

References (26)

1. Klein MC, Gauthier RJ, Robbins JM, Kaczorowski J, Jorgensen SH, Franco ED et al. Relationship of episiotomy to perineal trauma and morbidity, sexual dysfunction, and pelvic floor relaxation. Am J Obstet Gynecol 1994; 171: 591-8.
2. Basevi V, Cerrone L, Gori G. Resistance to changes of medical procedures in obstetrics. The role of mass media and community medicine. Epidemiol Prev 1994; 18: 194-9.
3. Reading AE, Sledmere CM, Cox DN, Campbell S. How women view post-episiotomy pain. BMJ 1982; 284: 243-6.
4. Macarthur A, Macarthur C. Perineal trauma and postpartum perineal pain (abstract). Am J Obstet Gynecol 1997; 176: S121.
5. Laska E, Sunshine A. Fenoprofen and codeine analgesia. Clin Pharmacol Ther 1981; 29: 606-16.
6. Norman SL, Jeavons BI, O'Brien PMS, Johnson IR. A double-blind comparison of a new Diclofenac pyrrolidine-codeine phosphate combination, codeine phosphate, and placebo in the relief of postepisiotomy pain. Clin Ther 1985; 7: 549-54.
7. Bloomfield S, Barden T, Mitchell J. Naproxen, aspirin, and codeine in postpartum uterine pain. Clin Pharmacol Ther 1983; 34: 414-21.
8. Sunshine A, Roure C, Olson N, Laska E, Zorrilla C, Rivera J. Analgesic efficacy of two Diclofenac pyrrolidinecodeine combinations for the treatment of postepisiotomy and postoperative pain. Clin Pharmacol Ther 1987; 42: 374-80.
9. Schachtel B, Thoden W, Baybutt R. Diclofenac pyrrolidine and acetaminophen in the relief of postpartum episiotomy pain. J Clin Pharmacol 1989; 29: 550-3.
10. Yonkeura M, Turner J, diZerega G. Double-blind comparison of meclofenamate sodium with codeine and placebo for the pain of episiotomy. Clin Ther 1987; 9: 578-93.
11. Olson NZ, Sunshine A, Zighelboim I, DeCastro A. Onset and duration of analgesia of diclofenac potassium in the treatment of postepisiotomy pain. Am J Ther 1997; 4: 239-46.
12. Facchinetti F, De Pietri R, Giunchi M, Genazzani AR. Use of meclofenamic acid in gynecology and obstetrics: effects on post-surgical stress. Clin J Pain 1991; 7: S60-3.
13. Vangen O, Doessland S, Lindbaek E. Comparative study of ketorolac and paracetamol/codeine in alleviating pain following gynaecological surgery. J Int Med Res 1988; 16: 443-51.
14. Walters B, Smith V, De Swiet M. Pain relief after episiotomy - a comparative study of suprofen and dihydrocodeine. Br J Obstet Gynaecol 1985; 92: 1160-3.
15. Jacobson J, Bertilson S. Analgesic efficacy of paracetamol/ codeine and paracetamol/dextropropoxyphene in pain after episiotomy and ruptures in connection with childbirth. J Int Med Res 1987; 15: 89-95.
16. Barden J, Edwards J, Moore R, McQuay H. Single dose oral diclofenac for postoperative pain. Cochrane Database Syst Rev 2004: 2: CD004768.
17. Forrest JB, Camu F, Greer IA, Kehlet H, Abdalla M, Bonnet F et al. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth 2002; 88: 227-33.
18. Sunshine A, Olson NZ. Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. J Clin Pharmacol 1988; 28: S47-54.
19. Searles JA, Pring DW. Effective analgesia following perineal injury during childbirth: a placebo controlled trial of prophylactic rectal diclofenac. Br J Obstet Gynaecol 1998; 105: 627-31.
20. Tuncer S, Pirbudak L, Balat O, Capar M. Adding ketoprofen to intravenous patient-controlled analgesia with tramadol after major gynecological cancer surgery: a double-blinded, randomized, placebo-controlled clinical trial. Eur J Gynaecol Oncol 2003; 24: 181-4.
21. Benhamou D, Bouaziz H, Zerrouk N, Preaux N. Audit of ketoprofen prescribing after orthopedic and general surgery. Can J Anaesth 1999; 46: 109-13.
22. Alexander R, El-Moalem HE, Gan TJ. Comparison of the morphine-sparing effects of diclofenac sodium and ketorolac tromethamine after major orthopedic surgery. J Clin Anesth 2002; 14: 187-92.
23. Valanne J, Korttila K, Ylikorkala O. Intravenous diclofenac sodium decreases prostaglandin synthesis and postoperative symptoms after general anaesthesia in outpatients undergoing dental surgery. Acta Anaesthesiol Scand 1987; 31: 722-7.
24. Cooper SA. Ketoprofen in oral surgery pain: a review. J Clin Pharmacol 1988; 28: S40-6.
25. Fini A, Fazio G, Rapaport I. Diclofenac/N-(2-hydroxyethyl) pyrrolidine: a new salt for an old drug. Drugs Exp Clin Res 1993; 19: 81-8.
26. Fini A, Fazio G, Orienti I, Zecchi V, Rapaport I. Chemical properties-dissolution relationship. IV. Behaviour in solution of the diclofenac/N-(2-hydroxyethyl) pyrrolidine salt (DHEP). Pharm Acta Helv 1991; 66: 201-3.