Brittle nail syndrome: A pathogenesis-based approach with a proposed grading system

Journal of the American Academy of Dermatology

Volumn 53, Issue 4, 2005, Pages 644-651

  Van De Kerkhof, Peter C M ^a   Pasch, Marcel C ^a   Scher, Richard K ^b   Kerscher, Martina ^c   Gieler, Uwe ^d   Haneke, Eckard ^a   Fleckman, Philip ^e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NewYork Presbyterian Hospital   (United States)

^c UNIVERSITY OF HAMBURG   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; EMOLLIENT AGENT;

BRITTLE NAIL SYNDROME; CLINICAL FEATURE; DAILY LIFE ACTIVITY; DIFFERENTIAL DIAGNOSIS; EXPERIENCE; HUMAN; KERATINIZATION; NAIL DISEASE; ONYCHORRHEXIS; ONYCHOSCHYZIA; PATHOGENESIS; PATIENT; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SCORING SYSTEM; SOCIAL PSYCHOLOGY;

DIAGNOSIS, DIFFERENTIAL; HUMANS; NAIL DISEASES; NAILS; QUALITY OF LIFE;

EID: 25844472451     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2004.09.002     Document Type: Review

References (52)

1. D. Lubach, W. Cohrs, and R. Wurzinger Incidence of brittle nails Dermatologica 172 1986 144 147
2. R.K. Scher Brittle nails Int J Dermatol 28 1989 515 516
3. L.A. Norton Incorporation of tymidine-methyl-H3 and glycine-2-H3 in the nail matrix and bed of humans J Invest Dermatol 56 1971 61 68
4. P. Kechijian Brittle fingernails Dermatol Clin 3 1985 421 429
5. P.D. Samman, and D.A. Fenton The nails in disease 4th ed. 1986 Heinemann London pp. 14-6
6. B. Forslind Biophysical studies of the normal nail Acta Derm Venereol 50 1970 161 168
7. J.C. Garson, F. Baltenneck, F. Leroy, C. Riele, and M. Müller Histological structure of human nails as studied by synchroton X-ray microdiffraction Cell Mol Biol 46 2000 1025 1034
8. B. Forslind, R. Wroblewski, and B.A. Afzelius Calcium and sulfur location in human nail J Invest Dermatol 67 1976 273 275
9. B.A. Turek, M. Vieu, M. Leduc, I.M. Nadvomik, and E. Jedla Water content and moisture-binding capacity of some types of human soft and hard horn Curr Med Res Opin 7 Suppl 2 1982 87 90
10. P. Samman Nail disorders caused by external influences J Cosm Chem 28 1977 351 356
11. L.A. Norton Nail disorders: a review J Am Acad Dermatol 2 1980 451 467
12. K.A. Walters, G.L. Flynn, and J.R. Marvel Physiochemical characterization of the human nail: I. Pressure-sealed apparatus for measuring nail plate permeabilities J Invest Dermatol 76 1981 76 79
13. S. Wessel, M. Guidecka, G.B. Jemec, and H.C. Wulf Hydration of human nails investigated by NIR-FT-Raman-spectroscopy Biochim Biophys Acta 1433 1999 210 216
14. P. Fleckman Basic science of the nail unit R.K. Scher C.R. Daniel Nails: therapy, diagnosis, surgery 2nd ed. 1997 Saunders Philadelphia 48
15. R.J.G. Rycroft, and R. Baran Occupational abnormalities and contact dermatitis R. Baran R.P.R. Dawber Diseases of the nails and their management 3rd ed. 2001 Blackwell Oxford 1 79 205-65, 279
16. R.K. Scher, and A.B. Bodian Brittle nails Semin Dermatol 10 1991 21 25
17. A.S. Geyer, N. Onumah, H. Uyttendaele, and R.K. Scher Modulation of linear nail growth to treat diseases of the nail J Am Acad Dermatol 50 2004 229 234
18. U. Runne, and C.E. Orfanos The human nail: structure, growth and pathological changes Curr Probl Dermatol 9 1981 102 149
19. P.D. Samman The nails in disease 5th ed. 1995 Butterworth-Heinemann Boston
20. R. Baran Principle modifications of the normal form of the nail M. Pierre The nail 1981 Churchill Livingston Edinburg 29
21. H. Silver, and B. Chiego Nails and nail diseases: III. Brittleness of nails (fragilitas unguium) J Invest Dermatol 3 1940 357 374
22. D. Lubach, and P. Beckers Wet working conditions increase brittleness of nails but do not cause it Dermatology 85 1992 120 122
23. R.K. Scher Cosmetics and ancillary preparations for the care of nails: composition, chemistry and adverse reaction J Am Acad Dermatol 6 1982 523 528
24. J.V. Klauder, and H. Brown Sulfur content of hair and nails in abnormal states Arch Dermatol Syph 34 1935 568 579
25. T. Brosche, A. Dressler, and D. Platt Age-associated changes in integral cholesterol and cholesterol sulfate concentrations in human scalp hair and finger nail clippings Aging Clin Exp Res 13 2001 131 138
26. H. Zaun Brüchiche Nägel: Objektivierung and Therapiekontrolle Hautarzt 48 1997 455 461
27. D. Lubach, and R. Wurzinger Spurenelemente in Proben brüchiger und nicht-brüchiger Fingernägel Derm Beruf Umwelt 34 1986 37 39
28. P. DeNicola, M. Morsiani, and G. Zavagli Nail diseases in internal medicine 1974 Charles C Thomas Springfield (IL)
29. M. Gupta, A. Gupta, and H. Haberman Dermatologic signs in anorexia nervosa and bulemia nervosa Arch Dermatol 123 1987 1386-90
30. F.R.K. Robson, and H.D. El-Tahawi Hardness of human nail as an index of nutritional status: a preliminary communication Br J Nutr 26 1971 233 236
31. M.S. Wallis, W.R. Bowen, and J.D. Guin Pathogenesis of onychoschizia (lamellar dystrophy) J Am Acad Dermatol 24 1991 44 48
32. A. Campbell, and G. McEwan Treatment of brittle nails and dry eyes Br J Dermatol 105 1981 113
33. V. Pardo-Costello, and O.A. Pardo Disease of the nails 3rd ed. 1960 Charles C Thomas Springfield (IL)
34. W.B. Bean Nail growth: thirty-five years of observation Arch Intern Med 140 1980 73 76
35. N. Orentreich, J. Markofsky, and J.H. Vogelman The effect of aging on the rate of linear nail growth J Invest Dermatol 73 1979 126 130
36. K. Hashimoto Ultrastructure of the human toenail: cell migration, keratinization and formation of the intercellular cement Arch Dermatol Forsch 240 1970 1 22
37. J.H. Wells, J. Haines, and C.L. Williams Severe morbid onychophagia: the classification as self-mutilation and a proposed model of maintenance Aust N Z J Psychiatry 32 1998 534 545
38. U.M.E. Schulze, C.V. Pettke-Rank, M. Kreienkamp, H. Hamm, E.B. Bröcker, and C. Wewetzer Dermatologic findings in anorexia and bulimia nervosa of childhood and adolescence Pediatr Dermatol 16 1999 90 94
39. S.C. Chao, and J.Y. Lee Brittle nails and dyspareunia as first clues to recurrences of malignant glucagonoma Br J Dermatol 146 2002 1071 1074
40. Z.D. Draelos Nail cosmetic issues Dermatol Clin 18 2000 675 683
41. E.M. DeJong, B.A. Seegers, M.K. Gulinck, J.B. Boezeman, and P.C. van de Kerkhof Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1728 patients Dermatology 193 1996 300 303
42. R.K. Scher Onychomycosis is more than a cosmetic problem Br J Dermatol 130 1994 15
43. D.P. Lubeck, D. Gause, J.R. Schein, L.E. Prebil, and L.P. Potter A health-related quality of life measure for use in patients with onychomycosis: a validation study Qual Life Res 8 1999 121 129
44. L.A. Drake, D.L. Patrick, P. Fleckman, J. Andr, R. Baran, and E. Haneke The impact of onychomycosis on quality of life: development of an international onychomycosis-specific questionnaire to measure patient quality of life J Am Acad Dermatol 41 1999 189 196
45. L.A. Drake, R.K. Scher, E.B. Smith, G.A. Faich, S.L. Smith, and J.J. Hong Effect of onychomycosis on quality of life J Am Acad Dermatol 38 1998 702 704
46. B.E. Elewski The effect of toenail onychomycosis on patient quality of life Int J Dermatol 36 1997 754 756
47. P.D. Samman Nail formation and some nail disorders J Soc Cosmet Chem 23 1972 405 413
48. A.Y. Finlay, P. Frost, A.D. Keith, and W. Snipes An assessment of factors influencing flexibility of human fingernails Br J Dermatol 103 1980 357 365
49. T.L. Tyson The effect of gelatin on fragile nails J Invest Dermatol 14 1950 323 325
50. S. Rosenberg, and K. Oster Gelatin in the treatment of brittle nails Conn Med 19 1955 171
51. V.E. Colombo, F. Gerber, M. Bronhofer, and G.L. Floersheim Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy J Am Acad Dermatol 23 1990 1127 1132
52. L.G. Hochman, R.K. Scher, and M.S. Meyerson Brittle nails: response to daily biotin supplementation Cutis 51 1993 303 305