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3
-
-
16244420711
-
-
(c) Conformationally unconstrained polyols, in general, prefers intermolecular to intramolecular O-H⋯O hydrogen bonding. The latter not only entails a high energy conformation with axial OH groups, but also a loss of one O-H⋯O hydrogen bond per intramolecular H-bond formed. For a recent article, see: A. Bonnet, J. Chisholm, W. D. S. Motherwell and W. Jones, CrystEngComm, 2005, 7, 71-95.
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0037833505
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(a) The hydroxyl groups in 1 and 2 are locked in an 'axial-rich' conformation owing to the transfusion of the hydrocarbon ring with the cyclohexanetetrol moiety. For a detailed account of the strategy involved, see: G. Mehta, S. S. Ramesh and M. K. Bera, Chem. Eur. J., 2003, 9, 2264-2272.
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For a detailed review on concomitant polymorphism, see: (a) J. Bernstein, R. J. Davey and J.-O. Henck, Angew. Chem., Intl. Ed., 1999, 38, 3440-3461;
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9
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The synthetic procedure adopted for the preparation of the tetrol 1 is a tactical modification of an earlier report, see: P. J. Garatt and F. Sondheimer, J. Chem. Soc. C, 1967, 565. The authors reported a tetrol of undetermined stereochemistry, melting in the range 253-256 uC. The present study therefore not only provides an unambiguous formulation of 1, but also enables one to identify the previously reported tetrol as corresponding to the major a-polymorph of 1.
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Garatt, P.J.1
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25844445988
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note
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int corresponds to subsequent merging of equivalent reflections in this space group.
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12
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2942731548
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14
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25844511744
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note
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2 tetrahedra along the main crystal axis. For recent examples, see ref. 8(j) and 8(k).
-
-
-
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15
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33749559350
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(i) R. Custelcean and M. D. Ward, Angew. Chem., Intl. Ed., 2002, 41, 1724-1728;
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25844432340
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note
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C-H⋯O ≥ 120° respectively, see ref. 4.
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