Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 9, 2005, Pages 1580-1589

  Radcliffe, Richard A ^a,b   Floyd, Kirsten L ^a   Drahnak, Joseph A ^a   Deitrich, Richard A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Ethanol Tolerance; Genetics; Inbred Strains

Indexed keywords

ALCOHOL;

ALCOHOL METABOLISM; ALCOHOL SENSITIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; GENETIC DISORDER; GENETIC SELECTION; HYPOTHERMIA; IMMUNOLOGICAL TOLERANCE; MOLECULAR PHYLOGENY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHTING REFLEX; SENSITIVITY ANALYSIS; STRAIN IDENTIFICATION;

ALCOHOLISM; ANIMALS; BODY TEMPERATURE; DRUG TOLERANCE; ETHANOL; MICE; MICE, INBRED STRAINS; RATS; RATS, INBRED STRAINS; REFLEX;

ANIMALIA;

EID: 25844461349     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000179208.05882.1f     Document Type: Article

References (63)

1. th ed. American Psychiatric Association, Washington, DC.
2. Browman KE, Rustay NR, Nikolaidis N, Crawshaw L, Crabbe JC (2000) Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacol Biochem Behav 67:821-829.
3. Cao W, Wehner JM, Collins AC (1995) Chronic intragastric infusion produces tolerance to ethanol in LS and SS mice. Alcohol 12:241-246.
4. Crabbe JC (1994) Tolerance to ethanol hypothermia in HOT and COLD mice. Alcohol Clin Exp Res 18:42-46.
5. Crabbe JC (1998) Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther 286:263-271.
6. Crabbe JC (2002) Alcohol and genetics: New models. Am J Med Genet 114:969-974.
7. Crabbe JC, Belknap JK, Buck KJ (1994a) Genetic animal models of alcohol and drug abuse. Science 264:1715-1723.
8. Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI (1994b) Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther 269:184-192.
9. Crabbe JC, Janowsky JS, Young ER, Kosobud A, Stack J, Rigter H (1982) Tolerance to ethanol hypothermia in inbred mice: Genotypic correlations with behavioral responses. Alcohol Clin Exp Res 6:446-458.
10. Crabbe JC, Kosobud A, Tam BR, Young ER, Deutsch CM (1987) Genetic selection of mouse lines sensitive (cold) and resistant (hot) to acute ethanol hypothermia. Alcohol Drug Res 7:163-174.
11. Crabbe JC, Metten P, Cameron AJ, Wahlsten D (2005) An analysis of the genetics of alcohol intoxication in inbred mice. Neurosci Biobehav R 28:785-502.
12. Crabbe JC, Phillips TJ (1993) Selective breeding for alcohol withdrawal severity. Behav Genet 23:171-177.
13. Crabbe JC, Phillips TJ, Kosobud A, Belknap JK (1990) Estimation of genetic correlation: Interpretation of experiments using selectively bred and inbred animals. Alcohol Clin Exp Res 14:141-151.
14. Crabbe JC, Rigter H, Uijlen J, Strijbos C (1979) Rapid development of tolerance to the hypothermic effect of ethanol in mice. J Pharmacol Exp Ther 208:128-133.
15. Crowell CR, Hinson RE, Siegel S (1981) The role of conditional drug responses in tolerance to the hypothermic effects of ethanol. Psychopharmacology 73:51-54.
16. Deitrich RA, Bludeau P, Erwin VG (2000) Phenotypic and genotypic relationships between ethanol tolerance and sensitivity in mice selectively bred for initial sensitivity to ethanol (SS and LS) or development of acute tolerance (HAFT and LAFT). Alcohol Clin Exp Res 24:595-604.
17. Draski LJ, Bice PJ, Deitrich RA (2001) Developmental alterations of ethanol sensitivity in selectively bred high and low alcohol sensitive rats. Pharmacol Biochem Behav 70:387-396.
18. Draski LJ, Deitrich RA, Menez JF (1997) Phenobarbital sensitivity in HAS and LAS rats before and after chronic administration of ethanol. Pharmacol Biochem Behav 57:651-657.
19. Draski LJ, Spuhler KP, Erwin VG, Baker RC, Deitrich RA (1992) Selective breeding of rats differing in sensitivity to the effects of acute ethanol administration. Alcohol Clin Exp Res 16:48-54.
20. Enoch MA, Goldman D (2001) The genetics of alcoholism and alcohol abuse. Curr Psychiatry Rep 3:144-151.
21. Eriksson K, Rusi M (1981) Finnish selection studies on alcohol-related behaviors: General outline, in Development of Animal Models as Pharmacogenetic Tools (McClearn GE, Deitrich RA, Erwin VG, eds), pp 87-117. US Government printing Office, Washington, DC.
22. Erwin VG, Deitrich RA (1996) Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol. J Pharmacol Exp Ther 279:1310-1317.
23. Erwin VG, Gehle VM, Deitrich RA (2000) Selectively bred lines of mice show response and drug specificity for genetic regulation of acute functional tolerance to ethanol and pentobarbital. J Pharmacol Exp Ther 293:188-195.
24. Erwin VG, Heston WDW, McClearn GE, Deitrich RA (1976) Effect of hypnotics on mice genetically selected for sensitivity to ethanol. Pharmacol Biochem Behav 4:679-683.
25. Goldstein DB (1989) Animal models developed by selective breeding: Some questions raised and a few answered, in Genetic Aspects of Alcoholism (Kiianmaa K, Tabakoff B, Saito T, eds), pp 229-238. Finnish Foundation for Alcohol Studies, Helsinki.
26. Johnson EO, Van Den Bree, M, Gupman AE, Pickens RW (1998) Extension of a typology of alcohol dependence based on relative genetic and environmental loading. Alcohol Clin Exp Res 22:1421-1429.
27. Kalant H (1996) Current state of knowledge about the mechanisms of alcohol tolerance. Addict Biol 1:133-141.
28. Kalant H, LeBlanc AE, Gibbins RJ (1971) Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol Rev 23:135-191.
29. Keir WJ, Deitrich RA (1990) Development of central nervous system sensitivity to ethanol and pentobarbital in Short- and Long-Sleep mice. J Pharmacol Exp Ther 254:831-835.
30. Kirstein SL, Davidson KL, Ehringer MA, Sikela JM, Erwin VG, Tabakoff B (2002) Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J Pharmacol Exp Ther 302:1238-1245.
31. Khanna JM, Chau A, Shah G (1996) Characterization of the phenomenon of rapid tolerance to ethanol. Alcohol 13:621-628.
32. Khanna JM, Kalant H, Shah G, Weiner J (1991) Rapid tolerance as an index of chronic tolerance. Pharmacol Biochem Behav 38:427-432.
33. Khanna JM, Le AD, LeBlanc AE, Shah G (1985) Initial sensitivity versus acquired tolerance to ethanol in rats selectively bred for ethanol sensitivity. Psychopharmacology 86:302-306.
34. Koob GF, Sanna PP, Bloom FE (1998) Neuroscience of addiction. Neuron 21:467-476.
35. Kurtz DL, Stewart RB, Zweifel M, Li TK, Froehlich JC (1996) Genetic differences in tolerance and sensitization to the sedative/hypnotic effects of alcohol. Pharmacol Biochem Behav 53:585-591.
36. Le AD, Kiianmaa K (1990) Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in AT and ANT rats. Psychopharmacology 102:11-16.
37. Le AD, Poulos CX, Cappell H (1979) Conditioned tolerance to the hypothermic effect of ethyl alcohol. Science 206:1109-1110.
38. Lewis SA, Kunz AL, Bell AE (1966) Error of intraperitoneal injections in rats. Lab Anim Care 16:505-507.
39. Lundquist F (1959) The determination of ethyl alcohol in blood and tissue. Methods Biochem Anal 7:217-251.
40. Markel PD, DeFries JC, Johnson TE (1995) Use of repeated measures in an analysis of ethanol-induced loss of righting reflex in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 19:299-304.
41. McClearn GE, Kakihana R (1981) Selective breeding for ethanol sensitivity: short-sleep and long- sleep mice, in Development of Animal Models as Pharmacogenetic Tools (McClearn GE, Deitrich RA, Erwin VG, eds), pp 147-159. US Government printing Office, Washington, DC.
42. Melchior CL, Tabakoff B (1984) A conditioning model of alcohol tolerance. Recent Dev Alcohol 2:5-16.
43. Mellanby E (1919) Alcohol: its absorption into and disappearance from the blood under different conditions. Med Res Committee Special Rep (Lond) 31:1-48.
44. Nestler EJ, Hope BT, Widnell KL (1993) Drug addiction: A model for the molecular basis of neural plasticity. Neuron 11:995-1006.
45. Newlin DB, Thomson JB (1990) Alcohol challenge with sons of alcoholics: A critical review and analysis. Psychol Bull 108:383-402.
46. Palmer MR, Basile AS, Proctor WR, Baker RC, Dunwiddie TV (1985) Ethanol tolerance of cerebellar Purkinje neurons from selectively outbred mouse lines: In vivo and in vitro electrophysiological investigations. Alcohol Clin Exp Res 9:291-296.
47. Peris J, Cunningham CL (1987) Stress enhances the development of tolerance to the hypothermic effect of ethanol. Alcohol Drug Res 7:187-193.
48. Phillips TJ, Lessov CN, Harland RD, Mitchell SR (1996) Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. J Pharmacol Exp Ther 277:613-623.
49. Ponomarev I, Crabbe JC (2002) Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common. Genes Brain Behav 1:82-57.
50. Radcliffe RA, Erwin VG, Draski L, Hoffmann S, Edwards J, Deng X-S, Bludeau P, Fay T, Lundquist K, Asperi W, Deitrich RA (2004) Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from Inbred High and Low Alcohol Sensitivity selectively bred rat lines. Alcohol Clin Exp Res 28:1796-1804.
51. Riley EP, Worsham ED, Lester D, Freed EX (1977) Selective breeding of rats for differences in reactivity to alcohol: An approach to an animal model of alcoholism, II: Behavioral measures. J Stud Alcohol 38:1705-1717.
52. Romm E, Collins AC (1987) Body temperature influences on ethanol elimination rate. Alcohol 4:189-198.
53. Rustay NR, Crabbe JC (2004) Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: Inbred strains and artificial selection. Behav Genet 34:441-451.
54. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189.
55. Schuckit MA (1998) Biological, psychological, and environmental predictors of the alcoholism risk: A longitudinal study. J Stud Alcohol 59:485-494.
56. Silveri MM, Spear LP (1999) Ontogeny of rapid tolerance to the hypnotic effects of ethanol. Alcohol Clin Exp Res 23:1180-1184.
57. Silveri MM, Spear LP (2001) Acute, rapid, and chronic tolerance during ontogeny: Observations when equating ethanol perturbation across age. Alcohol Clin Exp Res 25:1301-1308.
58. Smolen A, Smolen TN (1987) Demonstration of a threshold concentration for ethanol at the time of regaining the righting response in long-sleep and short-sleep mice. Alcohol Drug Res 7:279-283.
59. Tabakoff B, Melchoir CL, Hoffman PL (1982) Commentary on ethanol tolerance. Alcohol Clin Exp Res 6:252-259.
60. Tabakoff B, Ritzmann RF (1979) Acute tolerance in inbred and selected lines of mice. Drug Alcohol Dep 4:87-90.
61. Tabakoff B, Ritzmann RF, Raju TS, Deitrich RA (1980) Characterization of acute and chronic tolerance in mice selected for inherent differences in sensitivity to ethanol. Alcohol Clin Exp Res 4:70-73.
62. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link PJ, Rikke BA, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome 15:637-647.
63. Wu PH, Tabakoff B, Szabo G, Hoffman PL (2001) Chronic ethanol exposure results in increased acute functional tolerance in selected lines of HAFT and LAFT mice. Psychopharmacology 155:405-412.