Physiologic and symptomatic responses to low-level substances in individuals with and without chemical sensitivities: A randomized controlled blinded pilot booth study

Environmental Health Perspectives

Volumn 113, Issue 9, 2005, Pages 1178-1183

  Joffres, Michel R ^a   Sampalli, Tara ^a   Fox, Roy A ^a  

^a Nova Scotia Environmental Health Centre   (Canada)

Author keywords

Complex mixtures; Electrodermal response; Multiple chemical sensitivity; Pilot project; Randomized controlled trial; Skin conductance

Indexed keywords

GLUE; PLACEBO; SHAMPOO; SOAP;

ADAPTATION; ADULT; ARTICLE; BREATHING RATE; CLINICAL ARTICLE; COGNITION; CONTRAST SENSITIVITY; CONTROLLED STUDY; ELECTRODERMAL RESPONSE; EXPOSURE; FEMALE; HEART RATE; HUMAN; MULTIPLE CHEMICAL SENSITIVITY; PRIORITY JOURNAL; RANDOMIZATION; SKIN CONDUCTANCE; SKIN TEMPERATURE; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY;

ADHESIVES; ADULT; AIR POLLUTANTS; CASE-CONTROL STUDIES; COSMETICS; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; INHALATION EXPOSURE; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; ODORS; PILOT PROJECTS; SINGLE-BLIND METHOD; TOXICITY TESTS;

EID: 25844450930     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7198     Document Type: Article

References (33)

1. Bartha L, Baumzweiger W, Buscher DS. 1999. Multiple chemical sensitivity: a 1999 consensus. Arch Environ Health 54:147-149.
2. Bascom R, Meggs WJ, Frampton M, Hudnell K, Killburn K, Kobal G, et al. 1997. Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation. Environ Health Perspect 105(suppl 2):531-537.
3. Bell IR, Baldwin CM, Fernandez M, Schwartz GE. 1999. Neural sensitization model for multiple chemical sensitivity: overview of theory and empirical evidence. Toxicol Ind Health 15:295-304.
4. Bell IR, Rossi J III, Gilbert ME, Kobel G, Morrow LA, Newlin DB, et al. 1997. Testing the neural sensitization and kindling hypothesis for illness from low levels of environmental chemicals. Environ Health Perspect 105(suppl):539-547.
5. Cullen MR. 1987. The worker with multiple chemical sensitivities: an overview. Occup Med 2:655-661.
6. Edelberg R. 1972. Electrical activity of the skin: its measurement and uses in psychophysiology. In: Handbook of Psychophysiology (Greenfield NS, Sternbach RA, eds). New York:Holt, 367-418.
7. Fiedler N, Kelly-McNeil K, Mohr S, Lehrer P, Opiekun RE, Lee C, et al. 2000. Controlled human exposure to methyl tertiary butyl ether in gasoline: symptoms, psychophysiologic and neurobehavioral responses of self-reported sensitive persons. Environ Health Perspect 108:753-763.
8. Fiedler N, Kipen H. 1997. Chemical sensitivity: the scientific literature. Environ Health Perspect 105(suppl 2):409-415.
9. Fiedler N, Kipen HM. 2001. Controlled exposures to volatile organic compounds in sensitive groups. Ann NY Acad Sci 933:24-37.
10. IPCS (International Programme on Chemical Safety). 1996. Conclusions and recommendations of a workshop on multiple chemical sensitivities (MCS). Regul Toxicol Pharmacol 24:S188-S189.
11. Joffres MR, Williams T, Sabo B, Fox RA. 2001. Environmental sensitivities: prevalence of major symptoms in a referral centre: the Nova Scotia Environmental Sensitivities Research Centre Study. Environ Health Perspect 109:161-165.
12. Kipen HM, Fiedler N. 2002a. Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge. Environ Health Perspect 110(suppl 4):597-599.
13. Kipen HM, Fiedler N. 2002b. The role of environmental factors in medically unexplained symptoms and related syndromes: conference summary and recommendations. Environ Health Perspect 110(suppl 4):591-595.
14. Kreutzer R, Neutra RR, Lashuay N. 1999. Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidemiol 150:1-12.
15. Kutsogiannis DJ, Davidoff AL. 2001. A multiple center study of multiple chemical sensitivity syndrome. Arch Environ Health 56:196-207.
16. Lim CL, Rennie C, Barry RJ, Bahramali H, Lazzaro I, Manor B, et al. 1997. Decomposing skin conductance into tonic and phasic components. Int J Psychophysiol 25:97-109.
17. Lorig TS. 1994. EEG and ERP studies of low-level odor exposure in normal subjects. Toxicol Ind Health 10:387-398.
18. McCraty R, Atkinson M, Tiller WA, Rein G, Watkins AD. 1995. The effects of emotions on short-term power spectrum analysis of heart rate variability. Am J Cardiol 76:1089-1093.
19. Meggs WJ. 1995. Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity. Environ Health Perspect 103:54-56.
20. Meggs WJ, Dunn KA, Bloch RM, Goodman PE, Davidoff AL. 1996. Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health 51:275-282.
21. Miller CS. 2001. The compelling anomaly of chemical intolerance. Ann NY Acad Sci 933:1-23.
22. Millqvist E, Bengtsson U, Lowhagen O. 1999. Provocations with perfume in the eyes induce airway symptoms in patients with sensory hyperreactivity. Allergy 54:495-499.
23. Nethercott JR, Davidoff LL, Curbow B, Abbey H. 1993. Multiple chemical sensitivities syndrome: toward a working case definition. Arch Environ Health 48:19-26.
24. Peterson LR, Peterson MJ. 1962. Minimal paired-associate learning. J Exp Psychol 63:521-527.
25. Randolph TG. 1961. Human ecology and susceptibility to the chemical environment. Ann Allergy 19:518-540.
26. Rea WJ, Ross GH, Johnson AR, Smilley RE, Sprague DE, Fenyves EJ, et al. 1991. Confirmation of chemical sensitivity by means of double-blind inhalant challenge of toxic volatile chemicals. Bol Asoc Med P R 83:389-393.
27. Schreiber JS, Hudnell HK, Geller AM, House DE, Aldous KM, Force MS, et al. 2002. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ Health Perspect 110:655-664.
28. Sobel N, Prabhakaran V, Hartley CA, Desmond JE, Glover GH, Sullivan EV, et al. 1999. Blind smell: brain activation induced by an undetected air-borne chemical. Brain 122:209-217.
29. Shusterman D. 2002. Review of the upper airway, including olfaction, as mediator of symptoms. Environ Health Perspect 110(suppl 4):649-653.
30. Sorg BA, Newlin DB. 2002. Sensitization as a mechanism for multiple chemical sensitivity: relationship to evolutionary theory. Scand J Psychol 43:161-167.
31. Sparks PJ, Daniell W, Black DW, Kipen HM, Altman LC, Simon GE, et al. 1994. Multiple chemical sensitivity syndrome: a clinical perspective. I. Case definition, theories of pathogenesis, and research needs. Occup Med 36:718-730.
32. Spurgeon A. 2002. Models of unexplained symptoms associated with occupational and environmental exposures. Environ Health Perspect 110(suppl 4):601-605.
33. Staudenmayer H, Selner JC, Buhr MP. 1993. Double-blind provocation chamber challenges in 20 patients presenting with "multiple chemical sensitivity." Regul Toxicol Pharmacol 18:44-53.