Design of HIV-1-PR inhibitors that do not create resistance: Blocking the folding of single monomers

Protein Science

Volumn 14, Issue 10, 2005, Pages 2668-2681

  Broglia, Ricardo A ^a,b,c   Tiana, Guido ^a,b   Sutto, Ludovico ^a,b   Provasi, Davide ^a,b   Simona, Fabio ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b INFN SEZIONE DI MILANO   (Italy)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Folding inhibition; HIV protease; Monte Carlo simulations; Simplified model

Indexed keywords

AMINO ACID; PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; DRUG DESIGN; DRUG TARGETING; HYDROPHOBICITY; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN FOLDING;

COMPUTER SIMULATION; DIMERIZATION; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MODELS, MOLECULAR; MONTE CARLO METHOD; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 25844448679     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.051670905     Document Type: Article

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