Enantioselective synthesis of aliphatic cyanohydrin acetates

Synlett

Volumn , Issue 15, 2005, Pages 2382-2384

  Veum, Lars ^a   Hanefeld, Ulf ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Asymmetric synthesis; Candida antarctica lipase B; Cyanohydrins; Dynamic kinetic resolution; Enzyme catalysis

Indexed keywords

ACETIC ACID DERIVATIVE; ALIPHATIC COMPOUND; CYANOHYDRIN; CYANOHYDRIN ACETATE; LIPASE B; POLACRILIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CHEMICAL REACTION KINETICS; ENANTIOSELECTIVITY; HYDROLYSIS; RACEMIZATION;

EID: 25444499736     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-872671     Document Type: Article

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20. For the procedure see the analytical scale experiment in ref. 6b.
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24. All conversion and enantiomeric purity was determined by chiral GC using a β-cyclodextrin column (CP-Chirasil-Dex CB 25m × 0.25 mm) using He with a linear gas velocity of 75 cm/s.
25. 3-C=O), 22.7 (C9), 24.6 (C8), 28.9 (C7), 29.3 (C6), 29.3 (C5), 29.4 (C4), 31.9 (C3), 32.3 (C2), 61.2 (C-O), 117.0 (CN), 169.2(C=O).
26. For the procedure, see the preparative scale experiment in ref. 6b.
27. 3), 25.3, 25.4, 25.8, 28.0, 28.1 and 40.5 (ring C), 65.6 (CH-O), 116.2 (CN), 169.3 (C=O).
28. 3-C=O), 22.3 (C5), 24.2 (C4), 30.9 (C3), 32.3 (C2), 61.2 (CH), 117.0 (CN), 169.2 (C=O).