메뉴 건너뛰기




Volumn 39, Issue 9, 2005, Pages 751-756

Low-dose oral methotrexate for maintaining Crohn's disease remission: Where we stand

Author keywords

Crohn's disease; Oral methotrexate

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; FOLIC ACID; MERCAPTOPURINE; METHOTREXATE; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PLACEBO; PREDNISONE;

EID: 25444496170     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mcg.0000177249.46130.a3     Document Type: Review
Times cited : (16)

References (41)
  • 1
    • 0028267896 scopus 로고
    • Frequency of glucocorticoid resistance and dependency in Crohn's disease
    • Munkliolm P, Langholz E, Davidsen M, et al. Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut. 1994;35:360-362.
    • (1994) Gut , vol.35 , pp. 360-362
    • Munkliolm, P.1    Langholz, E.2    Davidsen, M.3
  • 2
    • 0028790186 scopus 로고
    • A controlled double-blind study of azathioprine in the management of Crohn's disease
    • Candy S, Wright J, Gerber M, et al. A controlled double-blind study of azathioprine in the management of Crohn's disease. Gut. 1995;37:674-678.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3
  • 3
    • 11144329670 scopus 로고    scopus 로고
    • The ten-year single-center experience with 6-mcrcaptopurinc in the treatment of inflammatory bowel disease
    • Glazier KD, Palance AL, Griffel LH, et al. The ten-year single-center experience with 6-mcrcaptopurinc in the treatment of inflammatory bowel disease. J Clin Gastroenteroll. 2005;39:21-26.
    • (2005) J Clin Gastroenteroll , vol.39 , pp. 21-26
    • Glazier, K.D.1    Palance, A.L.2    Griffel, L.H.3
  • 4
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn's disease: A meta-analysis
    • Pearson DC, May GR, Pick GH, et al. Azathioprine and 6-mercaptopurine in Crohn's disease: a meta-analysis. Ann Intern Med. 1995;122:132-142.
    • (1995) Ann Intern Med , vol.122 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Pick, G.H.3
  • 5
    • 0018117298 scopus 로고
    • Double-blinded withdrawal trial of azathioprine as maintenance treatment for Crohn's disease
    • O'Donoghue DP, Dawaon AM, Powell-Tuck J, et al. Double-blinded withdrawal trial of azathioprine as maintenance treatment for Crohn's disease. Lancet. 1978;2:955-957.
    • (1978) Lancet , vol.2 , pp. 955-957
    • O'Donoghue, D.P.1    Dawaon, A.M.2    Powell-Tuck, J.3
  • 6
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn's disease
    • Candy S, Wright J, Gerber M, et al. A controlled double blind study of azathioprine in the management of Crohn's disease. Gut. 1995;37:674-678.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3
  • 7
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT 1 randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT 1 randomised trial. Lancet. 2002;359:1541-1549.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 8
    • 0037345575 scopus 로고    scopus 로고
    • Low dose methotrexate in inflammatory bowel disease: Current status and future directions
    • Oliver S, Jurgen S. Low dose methotrexate in inflammatory bowel disease: current status and future directions. Am J Gastroenterol. 2003;98:530-537.
    • (2003) Am J Gastroenterol , vol.98 , pp. 530-537
    • Oliver, S.1    Jurgen, S.2
  • 9
    • 0343081012 scopus 로고    scopus 로고
    • Methotrexate in Crohn's disease: Long-term efficacy and toxicity
    • Lemann M, Zenjari T, Bouhnik Y. Methotrexate in Crohn's disease: long-term efficacy and toxicity. Am J Gastroenterol. 2000;95:1730-1734.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1730-1734
    • Lemann, M.1    Zenjari, T.2    Bouhnik, Y.3
  • 10
    • 0033755922 scopus 로고    scopus 로고
    • Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease
    • Te HS, Schiano TD, Kuan SF, et al. Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2000;95:3150-3156.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3150-3156
    • Te, H.S.1    Schiano, T.D.2    Kuan, S.F.3
  • 11
    • 0031798177 scopus 로고    scopus 로고
    • How Canadian and US rheumatologists treat moderate and aggressive rheumatoid arthritis: A survey
    • Maetzel A, Bombardier C, Strand V, et al. How Canadian and US rheumatologists treat moderate and aggressive rheumatoid arthritis: a survey. J Rheumatol. 1998;25:2331-2338.
    • (1998) J Rheumatol , vol.25 , pp. 2331-2338
    • Maetzel, A.1    Bombardier, C.2    Strand, V.3
  • 12
    • 0036169930 scopus 로고    scopus 로고
    • Guidelines for the management of rheumatoid arthritis: 2002 Update
    • American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum. 2002;46:328-346.
    • (2002) Arthritis Rheum , vol.46 , pp. 328-346
  • 13
    • 0028226403 scopus 로고
    • Low dose methotrexate in rheumatic disease: Efficacy, side effects, and risk factors for side effects
    • Schnabel A, Gross WL. Low dose methotrexate in rheumatic disease: efficacy, side effects, and risk factors for side effects. Semin Arthritis Rheum. 1994;23:310-327.
    • (1994) Semin Arthritis Rheum , vol.23 , pp. 310-327
    • Schnabel, A.1    Gross, W.L.2
  • 14
    • 4043058521 scopus 로고    scopus 로고
    • Methotrexate for treating rheumatoid arthritis [last amended 1997]
    • CD000357
    • Suarez AM, Belseck E, Shea B, et al. Methotrexate for treating rheumatoid arthritis [last amended 1997]. Cochrane Database Syst Rev. 2002;4:CD000357.
    • (2002) Cochrane Database Syst Rev , vol.4
    • Suarez, A.M.1    Belseck, E.2    Shea, B.3
  • 15
    • 0030753245 scopus 로고    scopus 로고
    • Long-term follow-up of 453 rheumatoid arthritis patients treated with methotrexate: An open, retrospective, observational study
    • Bologna C, Viu P, Picot MC, et al. Long-term follow-up of 453 rheumatoid arthritis patients treated with methotrexate: an open, retrospective, observational study. Br J Rheumatol. 1997;36:535-540.
    • (1997) Br J Rheumatol , vol.36 , pp. 535-540
    • Bologna, C.1    Viu, P.2    Picot, M.C.3
  • 16
    • 0024517127 scopus 로고
    • Methotrexate induces clinical and histologie remission in patients with refractory inflammatory bowel disease
    • Kozarek RA, Patterson DJ, Gelfand MD, et al. Methotrexate induces clinical and histologie remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989;110:353-356.
    • (1989) Ann Intern Med , vol.110 , pp. 353-356
    • Kozarek, R.A.1    Patterson, D.J.2    Gelfand, M.D.3
  • 18
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn's disease
    • Feagan BG, Rochon J, Fedorak RN, et al. Methotrexate for the treatment of Crohn's disease. N Engl J Med. 1995;332:292-297.
    • (1995) N Engl J Med , vol.332 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 19
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease
    • Feagan BG, Fedorak RN, Irvine EJ, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. N Engl J Med. 2000;342:1627-1632.
    • (2000) N Engl J Med , vol.342 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3
  • 20
    • 0024216625 scopus 로고
    • Pharmacokinetics of subcutaneous methotrexate
    • Balis FM, Mirro J, Reaman GH, et al. Pharmacokinetics of subcutaneous methotrexate. J Clin Oncol. 1988;6:1882-1886.
    • (1988) J Clin Oncol , vol.6 , pp. 1882-1886
    • Balis, F.M.1    Mirro, J.2    Reaman, G.H.3
  • 21
    • 0025190680 scopus 로고
    • Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis
    • Brooks PJ, Spruill WJ, Parish RC, et al. Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis. Arthritis Rheum. 1990;33:91-94.
    • (1990) Arthritis Rheum , vol.33 , pp. 91-94
    • Brooks, P.J.1    Spruill, W.J.2    Parish, R.C.3
  • 22
    • 0031596842 scopus 로고    scopus 로고
    • Methotrexate in patients with Crohn's disease after 6-mercaptopurine
    • Mack DR, Young R, Kaufman SS, et al. Methotrexate in patients with Crohn's disease after 6-mercaptopurine. J Pediatr. 1998;132:830-835.
    • (1998) J Pediatr , vol.132 , pp. 830-835
    • Mack, D.R.1    Young, R.2    Kaufman, S.S.3
  • 23
    • 25444527885 scopus 로고    scopus 로고
    • Methotrexate shortage expected to last for months
    • Kirn TF. Methotrexate shortage expected to last for months. Rheumatol News. 2005;4:1-2.
    • (2005) Rheumatol News , vol.4 , pp. 1-2
    • Kirn, T.F.1
  • 24
    • 0022637441 scopus 로고
    • Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
    • Bagott JE, Vaughan WH, Hudson BB. Inhibition of 5-aminoimidazole-4- carboxamide ribotide transformylase, adenosine deaminase and 5'adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J. 1986;236:193-200.
    • (1986) Biochem J , vol.236 , pp. 193-200
    • Bagott, J.E.1    Vaughan, W.H.2    Hudson, B.B.3
  • 25
    • 0027139914 scopus 로고
    • The anti-inflammatory mechanism of methotrexate: Increased adenosine release at inflamed sites diminished leukocyte accumulation in an vivo model of inflammation
    • Cronstein BN, Naime D, Ostad E. The anti-inflammatory mechanism of methotrexate: increased adenosine release at inflamed sites diminished leukocyte accumulation in an vivo model of inflammation. J Clin Invest. 1993;92:2675-2682.
    • (1993) J Clin Invest , vol.92 , pp. 2675-2682
    • Cronstein, B.N.1    Naime, D.2    Ostad, E.3
  • 26
    • 0030462249 scopus 로고    scopus 로고
    • Molecular therapeutics: Methotrexate and its mechanism of action
    • Cronstein BN. Molecular therapeutics: methotrexate and its mechanism of action. Arthritis Rheum. 1996;39:1951-1960.
    • (1996) Arthritis Rheum , vol.39 , pp. 1951-1960
    • Cronstein, B.N.1
  • 27
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells
    • Genestier L, Paillot R, Fournel S, et al. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest. 1998;102:322-328.
    • (1998) J Clin Invest , vol.102 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3
  • 28
    • 0032936786 scopus 로고    scopus 로고
    • Recent advances in the understanding of mechanism of membrane transporter of folate and antifolates
    • Sierra EE, Goldman ID. Recent advances in the understanding of mechanism of membrane transporter of folate and antifolates. Semin Oncol. 1999;26:11-23.
    • (1999) Semin Oncol , vol.26 , pp. 11-23
    • Sierra, E.E.1    Goldman, I.D.2
  • 29
    • 0026476410 scopus 로고
    • Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis
    • Weitman SD, Weinberg AG, Coney LR, et al. Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res. 1992;52:6708-6711.
    • (1992) Cancer Res , vol.52 , pp. 6708-6711
    • Weitman, S.D.1    Weinberg, A.G.2    Coney, L.R.3
  • 30
    • 0026710176 scopus 로고
    • Effect of food on bioavailability of low-dose methotrexate in patients with rheumatoid arthritis
    • Oguey D, Kolliker F, Gerber NJ, et al. Effect of food on bioavailability of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 1992;35:611-614.
    • (1992) Arthritis Rheum , vol.35 , pp. 611-614
    • Oguey, D.1    Kolliker, F.2    Gerber, N.J.3
  • 31
    • 0027744086 scopus 로고
    • A comparison of low dose methotrexate bioavailability: Oral solution, oral tablet, subcutaneous and intramuscular dosing
    • Jundt JW, Browne BA, Fiocco GP, et al. A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing. J Rheumatol. 1993;20:1845-1849.
    • (1993) J Rheumatol , vol.20 , pp. 1845-1849
    • Jundt, J.W.1    Browne, B.A.2    Fiocco, G.P.3
  • 32
    • 0030791403 scopus 로고
    • Why intramuscular methotrexate works better than oral drug in patients with rheumatoid arthritis
    • Hamilton RA, Kremer JM. Why intramuscular methotrexate works better than oral drug in patients with rheumatoid arthritis. Br J Rheumatol. 1995;36:86-90.
    • (1995) Br J Rheumatol , vol.36 , pp. 86-90
    • Hamilton, R.A.1    Kremer, J.M.2
  • 33
    • 0021923633 scopus 로고
    • Efficacy of low-dose MTZ in rheumatoid arthritis
    • Weinblatt ME, Coblyn JS, Fox DA, et al. Efficacy of low-dose MTZ in rheumatoid arthritis. N Engl J Med. 1985;312:818-822.
    • (1985) N Engl J Med , vol.312 , pp. 818-822
    • Weinblatt, M.E.1    Coblyn, J.S.2    Fox, D.A.3
  • 34
    • 0030739717 scopus 로고    scopus 로고
    • The absorption of low-dose methotrexate in patients with inflammatory bowel disease
    • Moshkowitz M, Oren R, Tishler M, et al. The absorption of low-dose methotrexate in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 1997;11:569-573.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 569-573
    • Moshkowitz, M.1    Oren, R.2    Tishler, M.3
  • 35
    • 0041843894 scopus 로고    scopus 로고
    • Bioavailability of oral vs. subcutaneous methotrexate in patients with Crohn's disease
    • Kurnik D, Loebstein R, Fishbein E, et al. Bioavailability of oral vs. subcutaneous methotrexate in patients with Crohn's disease. Aliment Pharmacol Ther. 2003;18:57-63.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 57-63
    • Kurnik, D.1    Loebstein, R.2    Fishbein, E.3
  • 36
    • 8244261815 scopus 로고
    • Dose oral methotrexate (MTX) therapy maintain clinical remission in inflammatory bowel disease (IBD)?
    • Kozarek RA, Patterson DJ, Ball TJ, et al. Dose oral methotrexate (MTX) therapy maintain clinical remission in inflammatory bowel disease (IBD)? Gastroenterology. 1989;96:A272.
    • (1989) Gastroenterology , vol.96
    • Kozarek, R.A.1    Patterson, D.J.2    Ball, T.J.3
  • 37
    • 0027454451 scopus 로고
    • Low-dose oral methotrexate in refractory inflammatory bowel disease
    • Baron TH, Truss CD, Elson CO. Low-dose oral methotrexate in refractory inflammatory bowel disease. Dig Dis Sci. 1993;38:1851-1856.
    • (1993) Dig Dis Sci , vol.38 , pp. 1851-1856
    • Baron, T.H.1    Truss, C.D.2    Elson, C.O.3
  • 38
    • 4243749181 scopus 로고
    • Treatment of refractory Crohn's disease (CD) with methotrexate
    • Chamiot-Prieur C, Lemann M, Mesnard B, et al. Treatment of refractory Crohn's disease (CD) with methotrexate. Gastroenterology. 1993;104:A680.
    • (1993) Gastroenterology , vol.104
    • Chamiot-Prieur, C.1    Lemann, M.2    Mesnard, B.3
  • 39
    • 0030784425 scopus 로고    scopus 로고
    • Methotrexate in chronic active Crohn's disease: A double-blind, randomized, Israeli multicenter trial
    • Oren R, Moshkowitz M, Odes S, et al. Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial. Am J Castroenterol. 1997;92:2203-2209.
    • (1997) Am J Castroenterol , vol.92 , pp. 2203-2209
    • Oren, R.1    Moshkowitz, M.2    Odes, S.3
  • 40
    • 0009447497 scopus 로고    scopus 로고
    • Methotrexate in Crohn's disease: Results of a randomized, double-blind, placebo-controlled trial
    • Arora S, Katkov W, Cooley J, et al. Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1999;46:1724-1729.
    • (1999) Hepatogastroenterology , vol.46 , pp. 1724-1729
    • Arora, S.1    Katkov, W.2    Cooley, J.3
  • 41
    • 1542603602 scopus 로고    scopus 로고
    • Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: A randomized, investigator-blind study
    • Ardizzone S, Bollani S, Manzionna G, et al. Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: a randomized, investigator-blind study. Dig Liver Dis. 2003;35:619-627.
    • (2003) Dig Liver Dis , vol.35 , pp. 619-627
    • Ardizzone, S.1    Bollani, S.2    Manzionna, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.