A longitudinal study of operant responding in rats irradiated when 2 months old

Radiation Research

Volumn 164, Issue 4 II, 2005, Pages 552-555

  Rabin, Bernard M ^a   Joseph, James A ^b   Shukitt Hale, Barbara ^b  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; INSTRUMENTAL CONDITIONING; LONGITUDINAL STUDY; MALE; NONHUMAN; PARTICLE RADIATION; PERFORMANCE; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT; REWARD;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

AGE FACTORS; ANIMALS; CONDITIONING, OPERANT; HEAVY IONS; IRON; MALE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT SCHEDULE;

EID: 25444489288     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3349.1     Document Type: Conference Paper

References (17)

1. 56Fe heavy particle irradiation: Implications for manned space flights. Radiat. Res. 130, 88-93 (1990).
2. 56Fe heavy-particle irradiation-induced deficits in striatal muscarinic receptor sensitivity by selective cross-activation/inhibition of second-messenger systems. Radiat. Res. 139, 60-66 (1994).
3. 56Fe-particle radiation exposure. Radiat. Res. 154, 28-33 (2000).
4. 56Fe particles or protons on fixed-ratio operant responding in rats. J. Radiat. Res. 43 (Suppl.), S225-S228 (2002).
5. G. Casadesus, B. Shukitt-Hale, I. Cantuti-Castelvetri, B. M. Rabin and J. A. Joseph, The effects of heavy particle irradiation on exploration and response to environmental change. Adv. Space Res 33, 1340-1346 (2004).
6. J. A. Joseph, B. Shukitt-Hale, J. McEwen and B. M. Rabin, CNS-induced deficits of heavy particle irradiation in space: The aging connection. Adv. Space Res. 25, 2057-2064 (2004).
7. J. D. Salamone, A. Wisniecki, B. B. Carlson and M. Correa, Nucleus accumbens dopamine depictions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement. Neuroscience 105, 863-870 (2001).
8. J. D. Salamone and M. Correa, Motivational views of reinforcement: Implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav. Brain Res. 137, 3-25 (2002).
9. M. D. Lindner, M. A. Plone, J. M. Francis, T. J. Blaney, J. D. Salamone and D. F. Emerich, Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task. Behav. Brain Res. 86, 25-40 (1997).
10. M. D. Lindner, C. K. Cain, M. A. Plone, B. R. Frydel, T. J. Blaney, D. F. Emerich and M. R. Hoane, Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. Behav. Brain Res. 102, 1-16 (1999).
11. J. D. Salamone, P. A. Kurth, L. D. McCullough, J. D. Sokolowski and M. S. Cousins, The role of brain dopamine in response initiation: Effects of haloperidol and regionally specific dopamine depletions on the local rate of instrumental responding. Brain Res. 628, 218-226 (1993).
12. M. N. Friedman and G. A. Gerhardt, Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiol. Aging 13, 325-332 (1992).
13. C. Zeitlin, L. Heilbronn and J. Miller, Detailed characterization of the 1087 MeV iron-56 beam used for radiobiology at the Alternating Gradient Synchrotron. Radiat. Res. 149, 560-569 (1998).
14. J. De Vry, R. Schreiber, A. Daschke and K. R. Jentzsch, Effects of serotonin 5-HT (1/2) receptor agonists in a limited-access operant food paradigm in the rat. Eur. Neuropsychopharmacol. 13, 337-345 (2003).
15. J. De Vry and K. R. Jentzsch, Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food reinforced operant paradigm. Behav. Pharmacol. 15, 13-20 (2004).
16. E. Rossitch, Jr., R. A. King, D. Luttinger and C. B. Nemeroff, Behavioral effects of neurotensin: Operant responding and assessment of "anhedonia". Eur. J. Pharmacol. 163, 119-122 (1989).
17. G. E. Schultze, M. P. Gillam and M. G. Paule, Effect of atropine on operant test battery performance in rhesus monkeys. Life Sci. 51, 487-497 (1992).