Rapid heart rate increase at onset of exercise predicts adverse cardiac events in patients with coronary artery disease

Circulation

Volumn 112, Issue 13, 2005, Pages 1959-1964

  Falcone, Colomba ^a,b   Buzzi, Maria Paola ^a,b   Klersy, Catherine ^b   Schwartz, Peter J ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Exercise; Heart rate; Mortality; Nervous system, autonomic; Risk factors

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN;

ADULT; ARTICLE; CORONARY ARTERY DISEASE; EXERCISE; HEART DEATH; HEART INFARCTION; HEART RATE; HEART RATE VARIABILITY; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; PRIORITY JOURNAL; SYMPATHETIC TONE; VAGUS NERVE STIMULATION;

CARDIOVASCULAR DISEASES; CORONARY ARTERIOSCLEROSIS; EXERCISE TEST; HEART RATE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PROGNOSIS;

EID: 25444474001     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.545111     Document Type: Article

References (25)

1. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death; experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85(suppl I):I-77-I-91.
2. La Rovere MT, Schwartz PJ. Baroreflex sensitivity. In: Zipes DP, Jalife J, Eds. Cardiac Electrophysiology: From Cell to Bedside. 3rd ed. Philadelphia, Pa: WB Saunders; 2000:771-781.
3. Billman GE, Schwartz PJ, Stone HL. Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death. Circulation. 1982;66:874-880.
4. Schwartz PJ, Vanoli E, Stramba-Badiale M, De Ferrari GM, Billman GE, Foreman RD. Autonomic mechanisms and sudden death: new insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation. 1988;78:969-979.
5. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ, for the ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet. 1998;351: 478-484.
6. La Rovere MT, Pinna GD, Hohnloser SH, Marcus FI, Mortara A, Nohara R, Bigger JT Jr, Camm AJ, Schwartz PJ, on behalf of the ATRAMI Investigators. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implication for clinical trials. Circulation. 2001;103:2072-2077.
7. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ, and the Multicenter Postinfarction Research Group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol. 1987;59:256-262.
8. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger JT Jr, Camm AJ, Schwartz PJ, Malik M, on the behalf of the ATRAMI Investigators. Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (the Autonomic Tone and Reflexes After Myocardial Infarction Substudy). Am J Cardiol. 2002;89:184-190.
9. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart rate recovery immediately after exercise as a predictor of mortality. N Engl J Med. 1999;341:1351-1357.
10. Frolkis JP, Pothier CE, Blackstone EH, Lauer MS. Frequent ventricular ectopy after exercise as a predictor of death. N Engl J Med. 2003;348: 781-790.
11. Curfman GD, Hills LD. A new look at cardiac exercise testing. N Engl J Med. 2003;348:775-776.
12. De Ferrari GM, Vanoli E, Schwartz PJ. Cardiac vagal activity, myocardial ischemia and sudden death. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia. Pa: WB Saunders; 1995:422-434.
13. Schwartz PJ. The neural control of heart rate and risk stratification after myocardial infarction. Eur Heart J. 1999;20(suppl H):H33-H43.
14. Hull SS Jr, Vanoli E, Adamson PB, Verrier RL, Foreman RD, Schwartz PJ. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation. 1994;89:548-552.
15. Schwartz PJ, Priori SG. Sympathetic nervous system and cardiac arrhythmias. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia. Pa: WB Saunders: 1990:330-343.
16. Lown B, Verrier RL. Neural activity and ventricular fibrillation. N Engl J Med. 1976;294:1165-1170.
17. Huikuri HV, Jokinen V, Syvanne M, Nieminen MS, Airaksinen KE, Ikaheimo MJ, Koistinen JM, Kauma H, Kesaniemi AY, Majahalme S, Niemela KO, Frick MH. Heart rate variability and progression of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 1999;19: 1979-1985.
18. La Rovere MT, Pinna GD, Maestri R, Mortara A, Capomolla S, Febo O, Ferrari R, Franchini M, Gnemmi M, Opasich C, Riccardi PG, Traversi E, Cobelli F. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation. 2003;107: 565-570.
19. Camm AJ, Pratt CM, Schwartz PJ, Al-Khalidi HR, Spyt MJ, Holroyde MJ, Karam R, Sonnenblick EH, Brum JMG, on behalf of the AzimiLide post Infarct survival Evaluation (ALIVE) Investigators. Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification. Circulation. 2004;109:990-996.
20. Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetière P. Heart rate profile during exercise as a predictor of sudden death. N Engl J Med. 2005;352:1951-1958.
21. Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MS. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA. 2000;284:1392-1398.
22. Shetler K, Marcus R, Froelicher VF, Vora S, Kalisetti D, Prakash M, Do D, Myers J. Heart rate recovery: validation and methodologic issues. J Am Coll Cardiol. 2001;38:1980-1987.
23. Vivekananthan DP, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol. 2003;42: 831-838.
24. Myers J, Prakash M, Froelicher VF, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
25. La Rovere MT, Bersano C, Gnemmi M, Specchia G, Schwartz PJ. Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction. Circulation. 2002;106:945-949.