Polymorphism of the AHSG gene is associated with increased adipocyte β2-adrenoceptor function

Journal of Lipid Research

Volumn 46, Issue 10, 2005, Pages 2278-2281

  Lavebratt, Catharina ^a   Dungner, Elisabeth ^a   Hoffstedt, Johan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adipose; Alpha adrenoceptor; Alpha2 Heremans Schmid glycoprotein; Beta adrenoceptor; Fat cell

Indexed keywords

ALPHA2 HEREMANS SCHMID GLYCOPROTEIN; BETA ADRENERGIC RECEPTOR; CLONIDINE; DOBUTAMINE; FORSKOLIN; GLYCOPROTEIN; METHIONINE; PROTEIN AHSG; TERBUTALINE; THREONINE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADULT; AHSG GENE; ALLELE; ARTICLE; BIOPSY; BODY MASS; CONTROLLED STUDY; GENE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE;

ADIPOCYTES; ADULT; AGED; BLOOD PROTEINS; BODY MASS INDEX; GENE FREQUENCY; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 25444458654     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M500201-JLR200     Document Type: Article

References (17)

1. Dziegielewska, K. M., and W. M. Brown. 1995. Fetuin. Springer, Berlin, Heidelberg, New York.
2. Mathews, S. T., G. P. Singh, M. Ranalletta, V. J. Cintron, X. Qiang, A. S. Goustin, K-L. C. Jen, M. J. Charron, W. Jahnen-Dechent, and G. Grunberger. 2002. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. 51: 2450-2458.
3. Osawa, M., K. Umetsu, T. Ohki, T. Nagasawa, T. Suzuki, and S. Takeichi. 1997. Molecular evidence for human alpha 2-HS glyco protein (AHSG) polymorphism. Hum. Genet. 99: 18-21.
4. Osawa, M., W. Tian, H. Horiuchi, M. Kaneko, and K. Umetsu. 2005. Association of 2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. Hum. Genet. 116: 146-151.
5. Lavebratt, C., S. Wahlqvist, L. Nordfors, J. Hoffstedt, and P. Arner. 2005. AHSG gene variant is associated with leanness among Swedish men. Hum. Genet. 117: 54-60.
6. Arner, P. 1992. Adrenergic receptor function in fat cells. Am. J. Clin. Nutr. 55 (Suppl.): 228-236.
7. Kolaczynski J. W., L. M. Morales, J. H. Moore, Jr., R. V. Considine, Z. Pietrzkowski, P. F. Noto, J. Colberg, and J. F. Caro. 1994. A new technique for biopsy of human abdominal fat under local anaesthesia with Lidocaine. Int. J. Obes. Relat. Metab. Disord. 18: 161-166.
8. Lönnquist, F., H. Wahrenberg, L. Hellström, S. Reynisdottir, and P. Arner. 1992. Lipolytic catecholamine resistance due to decreased beta2-adrenoceptor expression in fat cells. J. Clin. Invest. 90:2175-2186.
9. Armitage, P., G. Berry, and J. Matthews. 2002. Statistical Methods in Clinical Research. Blackwell Science, Ltd., Oxford.
10. Guo, S. W., and E. A. Thompson. 1992. Performing the exact test of Hardy-Weinberg proportions for multiple alleles. Biometrics. 48: 361-372.
11. Kalabay, L., K. Cseh, A. Pajor, E. Baranyi, G. M. Csákány, Z. Melczer, G. Speer, M. Kovács, G. Siller, I. Karádi, et al. 2002. Correlation of maternal serum fetuin/2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. Eur. J. Endocrinol. 147: 243-248.
12. Auberger, P., L. Falquerho, J. O. Confreres, G. Pages, G. Le Cam, B. Rossi, and A. Le Cam. 1989. Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification and anti-mitogenic activity. Cell. 58: 631-640.
13. Srinivas, P. R., A. S. Wagner, L. V. Reddy, D. D. Deutsch, M. A. Leon, A. S. Goustin, and G. Grunberger. 1993. Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol. Endocrinol. 7: 1445-1455.
14. Dahlman, I., P. Eriksson, M. Kaaman, H. Jiao, C. M. Lindgren, J. Kere, and P. Arner. 2004. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia. 47: 1974-1979.
15. Reynisdottir, S., H. Wahrenberg, K. Carlstrom, S. Rossner, and P. Arner. 1994. Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta 2-adrenoceptors. Diabetologia. 37: 428-435.
16. Reynisdottir, S., K. Ellerfeldt, H. Wahrenberg, H. Lithell, and P. Arner. 1994. Multiple lipolysis defects in the insulin resistance (metabolic) syndrome. J. Clin. Invest. 93: 2590-2599.
17. Smith, U., and I. Lager. 1989. Insulin-antagonistic effects of counterregulatory hormones: clinical and mechanistic aspects. Diabetes Metab. Rm. 5:511-525.