Adherence to human vaginal epithelial cells signals for increased expression of Trichomonas vaginalis genes

Infection and Immunity

Volumn 73, Issue 10, 2005, Pages 6472-6478

  Kucknoor, Ashwini S ^a   Mundodi, Vasanthakrishna ^a   Alderete, J F ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ALPHA ACTININ; ALPHA TUBULIN; COMPLEMENTARY DNA; IRON; MONOCLONAL ANTIBODY;

ARTICLE; BACTERIAL GENE; CELL ADHESION; CONTROLLED STUDY; DNA LIBRARY; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROBIAL COLONIZATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SUBTRACTIVE HYBRIDIZATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; TRICHOMONAS VAGINALIS; UPREGULATION; VAGINA EPITHELIUM;

ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENES, PROTOZOAN; HUMANS; IRON; MEMBRANE PROTEINS; PROTOZOAN PROTEINS; TRICHOMONAS VAGINALIS; TRICHOMONAS VAGINITIS; UP-REGULATION; VAGINA;

EID: 25444435394     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.10.6472-6478.2005     Document Type: Article

References (53)

1. Addis, M. F., P. Rappelli, G. Delogu, F. Carta, P. Cappuccinelli, and P. L. Fiori. 1998. Cloning and molecular characterization of a cDNA clone coding for Trichomonas vaginalis alpha-actinin and intracellular localization of the protein. Infect. Immun. 66:4924-4931.
2. Alderete, J. F. 1999. Iron modulates phenotypic variation and phosphorylation of P270 in double-stranded RNA virus-infected Trichomonas vaginalis. Infect. Immun. 67:4298-4302.
3. Alderete, J. F., P. Deines, A. Gombosova, M. Valent, A. Yanoska, H. Fabusova, L. Kasmala, G. E. Garza, and E. C. Metcalfe. 1987. Phenotypes and protein-epitope phenotypic variation among fresh isolates of Trichomonas vaginalis. Infect. Immun. 55:1037-1041.
4. Alderete, J. F., and L. Kasmala. 1986. Monoclonal antibody to a major glycoprotein immunogen mediates differential complement-independent lysis of Trichomonas vaginalis. Infect. Immun. 53:697-699.
5. Alderete, J. F., J. Nguyen, V. Mundodi, and M. W. Lehker. 2004. Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis. Microb. Pathog. 36:263-271.
6. Alderete, J. F., J. L. O'Brien, R. Arroyo, J. A. Engbring, O. Musatovova, O. Lopez, C. Lauriano, and J. Nguyen. 1995. Cloning and molecular characterization of two genes encoding adhesion proteins involved in Trichomonas vaginalis cytoadherence. Mol. Microbiol. 17:69-83.
7. Arroyo, R., J. Engbring, and J. F. Alderete. 1992. Molecular basis of host epithelial cell recognition by Trichomonas vaginalis. Mol. Microbiol. 6:853-862.
8. Arroyo, R., A. Gonzalez-Robles, A. Martinez-Palomo, and J. F. Alderete. 1993. Signalling of Trichomonas vaginalis for amoeboid transformation and adhesion synthesis follows cytoadherence. Mol. Microbiol. 7:299-309.
9. Bakare, R. A., J. O. Ashiru, F. A. Adeyemi-Doro, C. C. Ekweozor, A. A. Oni, A. O. Okesola, and J. A. Adebayo. 1999. Non-gonococcal urethritis (NGU) due to Trichomonas vaginalis in Ibadan. West Afr. J. Med. 18:64-68.
10. Bennett, J. R., W. G. Barnes, and S. Coffman. 1989. The emergency department diagnosis of Trichomonas vaginalis. Ann. Emerg. Med. 18:564-566.
11. Bergmann, S., M. Rohde, G. S. Chhatwal, and S. Hammerschmidt. 2001. α-Enolase of Streptococcus pneumonias is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol. Microbiol. 40:1273-1287.
12. Bernal, D., J. E. de la Rubia, A. M. Carrasco-Abad, R. Toledo, S. Mas-Coma, and A. Marcilia. 2004. Identification of enolase as a plasminogen-binding protein in excretory-secretory products of Fasciola hepatica. FEBS Lett. 563:203-206.
13. Cao, W., C. Epstein, H. Liu, C. DeLoughery, N. Ge, J. Lin, R. Diao, H. Cao, F. Long, X. Zhang, Y. Chen, P. S. Wright, S. Busch, M. Wenck, K. Wong, A. G. Saltzman, Z. Tang, L. Liu, and A. Zilberstein. 2004. Comparing gene discovery from Asymetrix GeneChip microarrays and Clontech PCR-select cDNA subtraction: a case study. BMC Genomics 5:26.
14. Cohen, M. S., B. E. Britigan, M. French, and K. Bean. 1987. Preliminary observations on lactoferrin secretion in human vaginal mucus: variation during the menstrual cycle, evidence of hormonal regulation, and implications for infection with Neisseria gonorrhoeae. Am. J. Obstet. Gynecol. 157:1122-1125.
15. Colombo, M. I., J. Inglese, C. D'Souza-Schorey, W. Beron, and P. D. Stahl. 1995. Heterotrimeric G proteins interact with the small GTPase ARF. Possibilities for the regulation of vesicular traffic. J. Biol. Chem. 270:24564-24571.
16. Cotch, M. F., J. G. Pastorek II, R. P. Nugent, S. L. Hillier, R. S. Gibbs, D. H. Martin, D. A. Eschenbach, R. Edelman, J. C. Carey, J. A. Regan, M. A. Krohn, M. A. Klebanoff, A. V. Rao, G. G. Rhoads, et al. 1997. Trichomonas vaginalis associated with low birth weight and preterm delivery. Sex. Transm. Dis. 24:353-360.
17. Crouch, M. L., M. Benchimol, and J. F. Alderete. 2001. Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium. Microb. Pathog. 31:131-144.
18. Crouch, M. V., and J. F. Alderete. 2001. Trichomonas vaginalis has two fibronectin-like iron-regulated genes. Arch. Med. Res. 32:102-107.
19. Diamond, L. S. 1957. The establishment of various trichomonads of animals and man in axenic cultures. J. Parasitol. 43:488-490.
20. El-Shazly, A. M., H. M. El-Naggar, M. Soliman, M. El-Negeri, H. E. El-Nemr, A. E. Handousa, and T. A. Morsy. 2001. A study on Trichomonas vaginalis and female infertility. J. Egypt. Soc. Parasitol. 31:545-553.
21. Engbring, J. A., and J. F. Alderete. 1998. Three genes encode distinct AP33 proteins involved in Trichomonas vaginalis cytoadherence. Mol. Microbiol. 28:305-313.
22. Garcia, A. F., T. H. Chang, M. Benchimol, D. J. Klumpp, M. W. Lenker, and J. F. Alderete. 2003. Iron and contact with host cells induce expression of adhesins on surface of Trichomonas vaginalis. Mol. Microbiol. 47:1207-1224.
23. Grifantini, R., E. Bartolini, A. Muzzi, M. Draghi, E. Frigimelica, J. Berger, F. Randazzo, and G. Grandi. 2002. Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: from basic research to vaccine development. Ann. N. Y. Acad. Sci. 975:202-216.
24. Hobbs, M. M., P. Kazembe, A. W. Reed, W. C. Miller, E. Nkata, D. Zimba, C. C. Daly, H. Chakraborty, M. S. Cohen, and I. Hoffman. 1999. Trichomonas vaginalis as a cause of urethritis in Malawian men. Sex. Transm. Dis. 26:381-387.
25. Hosogi, Y., and M. J. Duncan. 2005. Gene expression in Porphyromonas gingivalis after contact with human epithelial cells. Infect. Immun. 73:2327-2335.
26. Kim, N., E. A. Marcus, Y. Wen, D. L. Weeks, D. R. Scott, H. C. Jung, I. S. Song, and G. Sachs. 2004. Genes of Helicobacter pylori regulated by attachment to AGS cells. Infect. Immun. 72:2358-2368.
27. Klumpp, D. J., S. G. Forrestal, J. E. Karr, C. S. Mudge, B. E. Anderson, and A. J. Schaeffer. 2002. Epithelial differentiation promotes the adherence of type 1-piliated Escherichia coli to human vaginal cells. J. Infect. Dis. 186:1631-1638.
28. Knodler, L. A., R. Noiva, K. Mehta, J. M. McCaffery, S. B. Aley, S. G. Svard, T. G. Nystul, D. S. Reiner, J. D. Silberman, and F. D. Gillin. 1999. Novel protein-disulfide isomerases from the early-diverging protist Giardia lamblia. J. Biol. Chem. 274:29805-29811.
29. Kucknoor, A. S., V. Mundodi, and J. F. Alderete. 2005. Trichomonas vaginalis adherence mediates differential gene expression in human vaginal epithelial cells. Cell. Microbiol. 7:887-897.
30. Kucknoor, A. S., V. Mundodi, and J. F. Alderete. 2005. Heterologous expression in Tritrichomonas foetus of functional Trichomonas vaginalis AP65 adhesin. BMC Mol. Biol. 6:5.
31. Lenker, M. W., and J. F. Alderete. 1992. Iron regulates growth of Trichomonas vaginalis and the expression of immunogenic trichomonad proteins. Mol. Microbiol. 6:123-132.
32. Lehker, M. W., R. Arroyo, and J. F. Alderete. 1991. The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis. J. Exp. Med. 174:311-318.
33. Lehker, M. W., T. H. Chang, D. C. Dailey, and J. F. Alderete. 1990. Specific erythrocyte binding is an additional nutrient acquisition system for Trichomonas vaginalis. J. Exp. Med. 171:2165-2170.
34. Molkanen, T., J. Tyynela, J. Helin, N. Kalkkinen, and P. Kuusela. 2002. Enhanced activation of bound plasminogen on Staphylococcus aureus by staphylokinase. FEBS Lett. 517:72-78.
35. Moodley, P., D. Wilkinson, C. Connolly, J. Moodley, and A. W. Sturm. 2002. Trichomonas vaginalis is associated with pelvic inflammatory disease in women infected with human immunodeficiency virus. Clin. Infect. Dis. 34:519-522.
36. Mundodi, V., A. S. Kucknoor, D. J. Klumpp, T. H. Chang, and J. F. Alderete. 2004. Silencing the ap65 gene reduces adherence to vaginal epithelial cells by Trichomonas vaginalis. Mol. Microbiol. 53:1099-1108.
37. O'Brien, J. L., C. M. Lauriano, and J. F. Alderete. 1996. Molecular characterization of a third malic enzyme-like AP65 adhesin gene of Trichomonas vaginalis. Microb. Pathog. 20:335-349.
38. Ohba, H., T. Harano, and T. Omura. 1981. Intracellular and intramembranous localization of a protein disulfide isomerase in rat liver. J. Biochem. (Tokyo) 89:889-900.
39. Pancholi, V., and V. A. Fischetti. 1998. Alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. J. Biol. Chem. 273:14503-14515.
40. Pancholi, V., P. Fontan, and H. Jin. 2003. Plasminogen-mediated group A streptococcal adherence to and pericellular invasion of human pharyngeal cells. Microb. Pathog. 35:293-303.
41. Park, Y., O. Yilmaz, I. Y. Jung, and R. J. Lamont. 2004. Identification of Porphyromonas gingivalis genes specifically expressed in human gingival epithelial cells by using differential display reverse transcription-PCR. Infect. Immun. 72:3752-3758.
42. Peterson, K. M., and J. F. Alderete. 1984. Iron uptake and increased intracellular enzyme activity follow host lactoferrin binding by Trichomonas vaginalis receptors. J. Exp. Med. 160:398-410.
43. Peterson, K. M., and J. F. Alderete. 1984. Selective acquisition of plasma proteins by Trichomonas vaginalis and human lipoproteins as a growth requirement for this species. Mol. Biochem. Parasitol. 12:37-48.
44. Peterson, K. M., and J. F. Alderete. 1984. Trichomonas vaginalis is dependent on uptake and degradation of human low density lipoproteins. J. Exp. Med. 160:1261-1272.
45. Quan, H., G. Fan, and C. C. Wang. 1995. Independence of the chaperone activity of protein disulfide isomerase from its thioredoxin-like active site. J. Biol. Chem. 270:17078-17080.
46. Sherman, K. J., W. H. Chow, J. R. Daling, and N. S. Weiss. 1988. Sexually transmitted diseases and the risk of tubal pregnancy. J. Reprod. Med. 33:30-34.
47. Singer-Kruger, B., H. Stenmark, A. Dusterheit, P. Philippsen, J. S. Yoo, D. Gallwitz, and M. Zerial. 1994. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J. Cell Biol. 125:283-298.
48. Sorvillo, F., A. Kovacs, P. Kerndt, A. Stek, L. Muderspach, and L. Sanchez-Keeland. 1998. Risk factors for trichomoniasis among women with human immunodeficiency virus (HIV) infection at a public clinic in Los Angeles County, California: implications for HIV prevention. Am. J. Trop. Med. Hyg. 58:495-500.
49. Sorvillo, F., L. Smith, P. Kerndt, and L. Ash. 2001. Trichomonas vaginalis, HIV, and African-Americans. Emerg. Infect. Dis. 7:927-932.
50. Tsai, C. D., H. W. Liu, and J. H. Tai. 2002. Characterization of an iron-responsive promoter in the protozoan pathogen Trichomonas vaginalis. J. Biol. Chem. 277:5153-5162.
51. Viikki, M., E. Pukkala, P. Nieminen, and M. Hakama. 2000. Gynaecological infections as risk determinants of subsequent cervical neoplasia. Acta Oncol. 39:71-75.
52. Wang, Z., and D. D. Brown. 1991. A gene expression screen. Proc. Natl. Acad. Sci. USA 88:11505-11509.
53. Weinstock, H., S. Berman, and W. Cates, Jr. 2004. Sexually transmitted diseases among American youth: incidence and prevalence estimates, 2000. Perspect. Sex. Reprod. Health 36:6-10.