Spontaneous Pregnancy Toxaemia (Ketosis) in Sheep and the Role of Insulin

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 45, Issue 5, 1998, Pages 255-266

  Henze, P ^a   Bickhardt, K ^a   Fuhrmann, H ^a   Sallmann, H P ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; OVIS; OVIS ARIES;

EID: 2542643866     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0442.1998.tb00825.x     Document Type: Article

References (39)

1. ANDREWS, A H , V. E. HOLLAND-HOWES, and J. I. D. WILKINSON, 1996: Naturally occurring pregnancy toxaemia in the ewe and treatment with recombinant bovine somatotropin. Small Rum. Res. 23, 191-197.
2. BERGMAN, E. N., 1971: Hyperketonemia, ketogenesis and ketone body metabolism. J. Dairy Sci. 54, 936-948.
3. BERGMAN, E. N., 1984: Disorders of carbohydrate and fat metabolism. in: SWENSON, M. J. (ed). Duke's Physiology of domestic animals. Cornell University Press, Ithaka, N. Y., and London.
4. BICKHARDT, K., 1994: Klinische Nierenfunktionsuntersuchungen bei Schafen. II. Einfluß von Gravidität, Lactation und Futterentzug sowie von Stoffwechselerkrankungen auf ie Nierenfunktion. Dtsch, tierärztl. Wschr. 101, 467-471.
5. BICKHARDT, K, G. GROCHOLL, und G. KONIG, 1989b: Untersuchungen zum Glucosestoffwechsel bei verschiedenen Reproduktionsstadien und bei Ketose mit Hilfe des intravenosen Glucose-Toleranz-Tests (IVGGT). J. Vet. Med. A. 36, 514-529.
6. BICKHARDT, K., G. KONIG, A. JAGER-BLOH, und T. H. MEYER, 1989a: Plasmakonzentrationen der Glucose und 3-Hydroxybuttersäure bei Mutterschafen unterschiedlicher Rassen und Reproduktionsstadien sowie bei Ketose. Zuchtungskunde 61 (2), 121-130.
7. BICKHARDT, K., M. NEUMANN, und C. STEINMANN, 1988: Zur Bestimmung von Metaboliten des Energiestoffwechsels in Leberbiopsieproben (Beitrag zur Charakterisierung der Schafketose). J. Vet. med. A 35, 790-799.
8. BICKHARDT, K., und G. KONIG, 1985: Blutmeßwerte von gesunden Mutterschafen der Merino- und Schwarzkopfrasse zur Zeit der Geburt (Referenzwerte). Dtsch. tierärztl. Wschr. 92, 319-322.
9. BLOM, A. K., K. HOVE, and J. J. NEDKITNE, 1976: Plasma insulin and growth hormone concentrations in pregnant sheep II: Post-absorptive levels in mid- and late pregnancy. Acta Endocrin. 82, 553-560.
10. BROCKMAN, R. P., and B. LAARVELD, 1985: Effects of insulin on net hepatic metabolism of acetate and β-hydroxybutyrate in sheep (ovis aries). Comp. Biochem. Physiol. 81A, 255-257.
11. CALLE, C., P. SANCHEZ-CASAS, M. C., CARRANZA, M. A., SIMON, and P MAYOR, 1988: Binding and antilipolytic action of insulin in isolated adipocytes from cortisol-treated rats. Rev. Esp. Fisiol. 44 (3), 309-314.
12. EVERTS, H., and H. KUIPER, 1983: Energy intake and pregnancy toxaemia in prolific ewes. Proc. 5th Internat. Conf. Prod. Disease in Farm Animals. Uppsala. Sweden: 133-136.
13. FORBES, J. M., and A. G. SINGLETON, 1964: Ovine pregnancy toxaemia: a review. Br. vet. J. 120, 56-58
14. FORD, E. J. H., J. EVANS, and I. ROBINSON, 1990: Cortisol in pregnancy toxaemia of sheep. Br. vet. J. 146, 539-542.
15. FREETLY, H. C., and J. KLINDT, 1996: Changes in gut and liver glucose, lactate, insulin, and oxygen flux in mature ewes during mesenteric or abdominal vena cava glucose infusion. J. Nutr. 126, 924-932.
16. GOULD, G. W., and G. D. HOLMAN, 1993: The glucose transporter family: structure, function and tissue-specific expression. Biochem. J. 295, 329-341.
17. GUESNET, P. M , M. J. MASSOUD, and Y. DEMARNE, 1991: Regulation of adipose tissue metabolism during pregnancy and lactation in the ewe. role insulin. J. Anim. Sci. 69, 2057-2065.
18. HAY JR., W. W., C. LIN., and H. K. MEZNARICH., 1988: Effect of high levels of insulin on glucose utilization and glucose production in pregnant and nonpregnant sheep. Proc. Soc. Exp. Biol. Med. 189, 275-284.
19. HENDERSON, G. D., L. C. READ, and A. M. SNOSWELL, 1982: Studies of liver lipids in normal, alloxandiabetic and pregnancy toxaemic sheep. Biochim.. Biophys. Acta 70, 236-241.
20. HENZE, P., 1992: Einfluß von Hochträchtigkeit und Fruhlaktation auf die Konzentration wichtiger Elektrolyte, Metabolite und stoffwechselwirksamer Hormone im Blutplasma von Schafen. Dissertation Tierärztliche Hochschule Hannover.
21. HENZE, P., K. BICKHARDT, und H. FURHMANN, 1994: Zur Mitwirkung der Hormone Insulin, Cortisol, Somatotropin und Gesamtostrogen an der Pathogenense der Schafketose. Dtsch. tierarztl. Wschr. 101, 61-65.
22. HOVE, K., and A. K. BLOM, 1976: Plasma insulin and growth hormone concentrations in pregnant sheep I: Diurnal variations in mid- and late pregnancy. Acta Endocr. 82, 544-552.
23. LINDNER, H. R., 1959: Blood cortisol in the sheep: normal concentration and changes in ketosis of pregnancy. Nature 184, 1645-1646.
24. LIPPMANN, R., und M. SCHAFER, 1985: Prophylaxe und Therapie der Ketose gravider Mutterschafe mit glucoplasischen Verbindungen. Wissenschaftliche Zeitschrift der Karl-Marx-Universität. Leipzig. Mathematisch-naturwissenschaftliche Reihe 34, 503-509.
25. MCCLYMONT, G. I, and B. P. SETCHELL, 1956: Ovine pregnancy toxaemia; III. Further evidence of the correlation of depth of hypoglycemia and induction of symptoms. Austr. Vet. J. 32, 22-25.
26. PAPPENHEIMER, J. R., and B. P. SETCHELL, 1973- Cerebral glucose transport and oxygen consumption in sheep and rabbits. J. Physiol. 233, 529-551.
27. RANAWEERA, A., 1980: Biochemical aspects of pregnancy toxaemia in ewes: a review. Ceylon Vet. J. 28, 1-4.
28. REID, R. L , 1968: The physiopathology of undernourishment in pregnant sheep, with particular reference to pregnancy toxemia. Adv. Vet. Sci. 12, 163-228.
29. RINGS, M., 1985: Therapeutic considerations in ketosis and hepatic lipidosis in cattle. Mod. Vet. Prac. 66, 523-526.
30. SAKAI, T., T. HAYAKAWA, M., HAMAKAWA, K, OGURA, and S. KUBO, 1993: Therapeutic effects of simultaneous use of glucose and insulin in ketotic cows. J. dairy Sci. 76, 109-114.
31. SCHLUMBOHM, C., H.-P. SPORLEDER, H., GURTLER, und J. HARMEYER, 1997: Insulinwirkung auf Glucose- und Fettstoffwechsel beim Schaf wahrend verschiedener Reproduktionsstadien bei Normo- und Hypocalcämie. Dtsch. tierärztl. Wschr. 104, 359-365.
32. SCOTT, P. R., N. D. SARGISON, C. D., PENNY, R. S., PIRIE, and J. M. KELLY, 1995: Cerebrospinal fluid and plasma glucose concentrations of ovine pregnancy toxaemia cases, inappetant ewes and normal ewes during late gestation. Br. vet. J. 151, 39-44.
33. SIGURDSSON, H., 1988a: The effect of pregnancy and feeding on the insulin and glucose concentrations in blood of ewes in late pregnancy. Acta vet. scand. 29, 401-405.
34. SIGURDSSON, H., 1988b: Susceptibility to pregnancy disease in ewes and its relation to gestational diabetes. Acta vet. scand. 29, 407-414.
35. STEEL, J. W., and A. LENG, 1973: Effects of plane of nutrition and pregnancy on gluconeogenesis in sheep. 1. The kinetics of glucose metabolism. Br. J. Nutr. 30, 451-473.
36. THOMSON, G. G., 1956: Observations on some treatments of ovine pregnancy toxaemia. NZ Vet, J. 4, 126-144.
37. VAN DER WALT, J. G., J. PROCOS, and F. J. LABUSCHAGNE, 1980: Glucose turnover, tolerance and insulin response in wethers, ewes and pregnant ewes in the fed and fasted state. Onderstepoort J. vet Res. 47, 173-178.
38. WASTNEY, M. E., A. C. ARCUS, R., BICKERSTAFFE, and J. E, WOLFF, 1982: Glucose tolerance in ewes and susceptibility to pregnancy toxaemia. Aust. J. Biol. Sci. 35, 381-392.
39. WASTNEY, M. E., J. E. WOLFF, and R. BICKERSTAFFE, 1983: Glucose turnover and hepatocytes glucose production of starved and toxaemic pregnant sheep. Aust. J. Biol. Sci. 36, 271-284.