Mild hyperhomocysteinemia in adult patients with sickle cell disease: A common finding unrelated to folate and cobalamin status

American Journal of Hematology

Volumn 76, Issue 2, 2004, Pages 114-120

  Dhar, Meekoo ^a   Bellevue, Rita ^a   Brar, Shabneet ^a   Carmel, Ralph ^a,b  

^a NEW YORK METHODIST HOSPITAL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cobalamin; Creatinine; Folate; Homocysteine; Sickle cell disease

Indexed keywords

COBALAMIN; CREATININE; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SICKLE CELL ANEMIA; VITAMIN SUPPLEMENTATION;

ADULT; AGED; ANEMIA, SICKLE CELL; CREATININE; FEMALE; FOLIC ACID; HEMOGLOBIN SC DISEASE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MIDDLE AGED; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; VITAMIN B 12;

EID: 2542630557     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20073     Document Type: Article

References (24)

1. van der Dijs FPL, Schnog JJB, Brouwer DAJ, et al. Elevated homocysteine levels indicate suboptimal folate status in pediatric sickle cell patients. Am J Hematol 1998;59:192-198.
2. 6 supplements in pediatric patients with sickle cell disease. Am J Hematol 2002;69: 239-246.
3. Balasa VV, Gruppo RA, Gartside PS, Kalinyak KA. Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease. J Pediatr Hematol Oncol 1999; 21:397-400.
4. Rodriguez-Cortes HM, Griener JC, Hyland K, et al. Plasma homocysteine levels and folate status in children with sickle cell anemia. J Pediatr Hematol Oncol 1999;3:219-223.
5. Balasa VV, Kalinyak KA, Bean JA, Stroop D, Gruppo RA. Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease. J Pediatr Hematol Oncol 2002;24:374-379.
6. Lowenthal EA, Mayo MS, Cornwell PE, Thornley-Brown D. Homocysteine elevation in sickle cell disease. J Am Coll Nutr 2000;19:608-612.
7. Ueland PM, Refsum H. Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease and drug therapy. J Lab Clin Med 1989;114:473-561.
8. Arnadottir M, Hultberg B. Homocysteine in renal disease. In: Carmel R, Jacobsen DW, editors. Homocysteine in health and disease. Cambridge, England: Cambridge University Press; 2001. p 321-330.
9. Blom HJ, de Vriese S. Why are homocysteine levels increased in kidney failure? A metabolic approach. J Lab Clin Med 2002;139: 262-268.
10. Lindenbaum J. Folic acid requirement in situations of increased need. In: Folic acid: biochemistry and physiology in relation to the human nutrition requirement. Washington, DC: National Academy of Sciences; 1977. p 256-276.
11. Sinow RM, Johnson CS, Karnaze DS, Siegel ME, Carmel R. Unsuspected pernicious anemia in a patient with sickle cell disease receiving routine folate supplementation. Arch Intern Med 1987;147:1828-1829.
12. Chen MC, Koshy M, Kennedy J. Pancytopenia caused by unsuspected pernicious anemia complicating sickle cell β-thalassemia. Southern Med J 1992;85:215-216.
13. Dhar M, Bellevue R, Carmel R. Pernicious anemia with neuropsychiatric dysfunction in a folate-supplemented patient with sickle cell anemia. N Engl J Med 2003;22:2204-2207.
14. Sklar AH, Campbell H, Caruana RJ, Lightfoot BO, Gaier JG, Milner P. A population study of renal function in sickle cell anemia. Int J Artif Organs 1990;13:231-236.
15. Thirup P, Ekelund S. Day-to-day, postprandial, and orthostatic variation of total plasma homocysteine. Clin Chem 1999;45:1280-1283.
16. Muskiet FAJ, van der Dijs FPL, Fokkema MR, Muskiet FD. Erythrocyte folate does not accurately reflect folate status in sickle cell disease. Clin Chem 2000;46:2015-2016.
17. Carmel R, Johnson CS. Racial patterns in pernicious anemia. Early age at onset and increased frequency of intrinsic factor antibody in black women. N Engl J Med 1978;298:647-650.
18. Carmel R. Mild transcobalamin I (haptocorrin) deficiency and low serum cobalamin concentrations. Clin Chem 2003;49:1367-1374.
19. Cumming AM, Olujohungbe A, Keeney S, Singh H, Hay CRM, Serjeant GR. The methylenetetrahydrofolate reductase gene C677T polymorphism in patients with homozygous sickle cell disease and stroke. Br J Haematol 1999;107:569-571.
20. Carmel R. Ethnic and racial factors in cobalamin metabolism and its disorders. Semin Hematol 1999;36:88-100.
21. 6 deficiency. In: Carmel R, Jacobsen DW, editors. Homocysteine in health and disease. Cambridge, England: Cambridge University Press; 2001. p 307-320.
22. 6 deficiency in sickle cell anemia. Am J Clin Nutr 1984;40:235-239.
23. 6 status of children with sickle cell disease. J Pediatr Hematol Oncol 2002; 24:463-469.
24. West MS, Wethers D, Smith J, Steinberg M. Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease. J Clin Epidemiol 1992;45:893-909.