Array reactors for parallel synthesis

Journal of Combinatorial Chemistry

Volumn 6, Issue 3, 2004, Pages 308-311

  Hughes, Philip F ^a,b   Graham, Thomas H ^a,c   Mendoza, Jose S ^a,d  

^a ELI LILLY AND COMPANY   (United States)

^b InnovaSyn LLC   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d Amphora Discovery Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATMOSPHERE; CHEMICAL REACTION; COMBINATORIAL CHEMISTRY; HEATING; HIGH THROUGHPUT SCREENING; HYDROGENATION; SYNTHESIS;

EID: 2542630532     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc0499643     Document Type: Article

References (13)

1. (a) Devlin, J. P. High Throughput Screening: The Discovery of Bioactive Substances; Marcel Dekker: New York, 1997.
2. (b) Jandeleit, B.; Schaefer, D. J.; Powers, T. S.; Turner, H. W.; Weinberg, W. H. Angew. Chem., Int. Ed. Engl. 1999, 38, 2494-2532.
3. (a) DeWitt, S. H.; Schroeder, M. C.; Stankovic, C. J.; Strode, J. E.; Czarnik, A. W. Drug Dev. Res. 1994, 33, 116-124.
4. (b) Gordon, E. M.; Kerwin, J. F., Jr. Combinatorial Chemistry and Molecular Diversity in Drug Discovery; Wiley: New York, 1998.
5. (c) Xie, W.; Firstine, S. M. J. Comb. Chem. 2004, 6, 24-26.
6. Listings of most commercially available equipment for combinatorial chemistry can be found on the web at sites such as http://www.combichemlab.com/ website/files/home.htm and http://www.combinatorial.com/instruments.html.
7. Detailed descriptions of the microtiter footprint, as defined by the Society for Biological Screening, can be found at http://sbsonline.com/msdc/ index.html.
8. Equipment parts are sometimes shown as partially transparent to help visualize how they work.
9. Scott, W. L.; Schonegg, R. A.; Cwi, C. L. Vessel Handling System Useful for Combinatorial Chemistry. U.S. Patent 5,785,927; 1998.
10. Model: IKAMAG RCT basic, IKA WORKS, Inc., 2635 Northchase Pkwy, SE, Wilmington, NC, 28405. Web site: http://www.ika.net/.
11. Stirring systems for 96-well plates are available from V&P Scientific, Inc., 9823 Pacific Heights Blvd., Suite T, San Diego, CA 92121. Web site: http://www.vp-scientific.com/. Orbital shakers with heating are available from J-KEM Scientific, Inc. 6970 Olive Blvd., St. Louis, MO 63130. Web site: http://www.jkem.com/.
12. Evolution of the reactor design is aimed primarily at reducing manufacturing costs and increasing ease of use and reusability. For example, the machined lip described for the SynthArray-96 will not bear repeated use as well as the O-rings. However, an O-ring design would require custom O-rings at a considerable cost. A very similar and functional previous design, which required pouring silicone around the tubes to make a seal, was never embraced by chemists in our labs.
13. Part No. 14-957-76A, Fisher Scientific International, Inc., Liberty Lane, Hampton, NH 03842.