Unique cell membrane expression of topoisomerase-II alpha as a useful diagnostic marker of liposarcoma

Pathology International

Volumn 54, Issue 3, 2004, Pages 145-150

  Endo, Hideko ^a   Hirokawa, Mitsuyoshi ^a   Ishimaru, Naozumi ^b   Tanaka, Yasushi ^a   Yamashita, Michiko ^a   Sakaki, Mika ^a   Hayashi, Yoshio ^b   Sano, Toshiaki ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Adipocytes; Lipoblasts; Liposarcoma; Malignant fibrous histiocytoma; S 100 protein; Topoisomerase II alpha

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); KI 67 ANTIGEN; PROTEIN S 100;

ARTICLE; CANCER TISSUE; CELL MEMBRANE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOBLASTOMA; LIPOSARCOMA; MYXOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADIPOCYTES; ADULT; AGED; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CELL MEMBRANE; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LIPOSARCOMA; MALE; MIDDLE AGED; S100 PROTEINS; SOFT TISSUE NEOPLASMS; STEM CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 2542614486     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2003.01600.x     Document Type: Article

References (12)

1. Gibas Z, Miettinen M, Limon J et al. Cytogenetic and immunohistochemical profile of myxoid liposarcoma. Am J Clin Pathol 1995; 103: 20-6.
2. Gebhard S, Coindre JM, Michels JJ et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 2002; 25: 601-16.
3. Iino K, Sasano H, Yabuki N et al. DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas. Mod Pathol 1997; 10: 901-7.
4. Tanoguchi K, Sasano H, Yabuki N et al. Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor. Mod Pathol 1998; 11: 186-93.
5. Ishimaru N, Yanagi K, Ogawa K et al. Possible role of organ-specific autoantigen for Fas ligand-mediated activation-induced cell death in murine Sjogren's Syndrome. J Immunol 2001; 167: 6031-7.
6. Bhat UG, Raychaudhuri P, Beck WT. Functional interaction between human topoisomerase II alpha and retinoblastoma protein. Proc Natl Acad Sci USA 1999; 95: 7859-64.
7. Hirokawa M, Shimizu M, Manabe T et al. Hyalinizing trabecular adenoma of the thyroid: its unusual cytoplasmic immunopositivity for MIB1. Pathol Int 1995; 45: 399-401.
8. Hirokawa M, Carney JA. Cell membrane and cytoplasmic staining for MIB-1 in hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 2000; 24: 575-8.
9. Hattori H. Sclerosing haemangioma of the lung is positive for MIB-1 in cell membrane and cytoplasmic staining pattern. Histopathology 2002; 40: 291-3.
10. Hashimoto H, Daimaru Y, Enjoji M. S-100 protein distribution in liposarcoma. An immunoperoxidase study with special reference to the distinction of liposarcoma from myxoid malignant fibrous histiocytoma. Virchows Arch 1984; 405: 1-10.
11. Angelo PDT, Wadden C, Fletcher CDM. S-100 protein staining in liposarcoma. Its diagnostic utility in the high-grade myxoid (round cell) variant. Appl Immunohisto 1996; 4: 95-101.
12. Yabuki N, Sasano H, Kato K et al. Immunohistochemical study of DNA topoisomerase II in human gastric disorders. Am J Pathol 1996; 149: 997-1007.