Quantitative lung perfusion scan as a predictor of aerosol distribution heterogeneity and disease severity in children with cystic fibrosis

Nuclear Medicine Communications

Volumn 25, Issue 6, 2004, Pages 563-569

  Itti, Emmanuel ^a   Fauroux, Brigitte ^a   Pigeot, Jérôme ^b   Isabey, Daniel ^b   Clement, Annick ^b   Evangelista, Eva ^b   Harf, Alain ^a   Meignan, Michel ^a  

^a UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^b ARMAND TROUSSEAU HOSPITAL   (France)

Author keywords

Cystic fibrosis; Distribution skew; Lung perfusion

Indexed keywords

TECHNETIUM 99M;

ADOLESCENT; ADULT; AEROSOL; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; FEMALE; HUMAN; ISOTOPE LABELING; LUNG PERFUSION; LUNG VOLUME; MALE; NEBULIZATION; PREDICTION; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC;

ADOLESCENT; ADULT; AEROSOLS; ALGORITHMS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; CYSTIC FIBROSIS; DRUG THERAPY, COMPUTER-ASSISTED; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LUNG; MALE; RADIOPHARMACEUTICALS; RESPIRATORY FUNCTION TESTS; SEVERITY OF ILLNESS INDEX; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 2542611364     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/01.mnm.0000126508.96340.1d     Document Type: Article

References (23)

1. Ramsey BW. Management of pulmonary disease in patients with cystic fibrosis. N Engl J Med 1996; 335:179-188.
2. Ranganathan SC, Dezateux C, Bush A, Carr SB, Castle RA, Madge S, et al. Airway function in infants newly diagnosed with cystic fibrosis. Lancet 2001; 358:1964-1965.
3. Sood N, Paradowski LJ, Yankaskas JR. Outcomes of intensive care unit care in adults with cystic fibrosis. Am J Respir Crit Care Med 2001; 163:335-338.
4. Ramsey BW, Astley SJ, Aitken ML, Burke W, Colin AA, Dorkin HL, et al. Efficacy and safety of short-term administration of aerosolized recombinant human desoxyribonuclease in patients with cystic fibrosis. Am Rev Respir Dis 1993; 148:145-151.
5. Mukhopadhyay S, Singh M, Cater JI, Ogston S, Franklin M, Olver RE. Nebulized antipseudomonal antibiotic therapy in cystic fibrosis: a meta-analysis of benefits and risks. Thorax 1996; 51:364-368.
6. Wojtczak HA, Kerby GS, Wagener JS, Copenhaver SC, Gotlin RW, Riches DW, et al. Beclomethasone diproprionate reduced airway inflammation without adrenal suppression in young children with cystic fibrosis: a pilot study. Pediatr Pulmonol 2001; 32:293-302.
7. Laube B, Links J, LaFrance N, Wagner H, Rosenstein B. Homogeneity of bronchopulmonary distribution of 99m-Tc aerosol in normal subjects and in cystic fibrosis patients. Chest 1989; 95:822-830.
8. Fauroux B, Itti E, Pigeot J, Isabey D, Meignan M, Ferry G, et al. Optimization of aerosol deposition by pressure support in children with cystic fibrosis. An experimental and clinical study. Am J Respir Crit Care Med 2000; 162:2265-2271.
9. Stanchina ML, Tantisira KG, Aquino SL, Wain JC, Ginns LC. Association of lung perfusion disparity and mortality in patients with cystic fibrosis awaiting lung transplantation. J Heart Lung Transplant 2002; 21:217-225.
10. Gaultier C, Boulé M, Allaire Y, Clement A, Buvry A, Girard F. Determination of capillary oxygen tension in infants and children: assessment of methodology and normal values during growth. Bull Physiopathol Respir (Nancy) 1978; 14:287-297.
11. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report of the Working Party on Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16:5-40.
12. Shwachman H, Kulczycki LL. Long-term study of one hundred and five patients with cystic fibrosis. Studies made over a five to fourteen year period. Am Med Assoc J Dis Child 1958; 96:6-15.
13. Agnew JE, Francis RA, Pavia D, Clarke SW. Quantitative comparison of 99Tcm-aerosol and 81Krm ventilation images. Clin Phys Physiol Meas 1982; 3:21-30.
14. Garrard CS, Gerrity TR, Schreiner JF, Yeates DB. Analysis of aerosol deposition in the healthy human lung. Arch Environ Health 1981; 36:184-193.
15. Bland J, Altman D. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310.
16. Centor RM. Signal detectability: the use of ROC curves and their analyses. Med Decis Making 1991; 11:102-106.
17. Alderson PO, Secker-Walker RH, Strominger DB, McAlister WH, Hill RL, Markham J. Quantitative assessment of regional ventilation and perfusion in children with cystic fibrosis. Radiology 1974; 111:151-155.
18. Piepsz A, Wetzburger C, Spehl M, Machin D, Dab I, Ham HR, et al. Critical evaluation of lung scintigraphy in cystic fibrosis: study of 113 patients. J Nucl Med 1980; 21:909-913.
19. Donnelly LF, Gelfand MJ, Brody AS, Wilmott RW. Comparison between morphologic changes seen on high-resolution CT and regional pulmonary perfusion seen on SPECT in patients with cystic fibrosis. Pediatr Radiol 1997; 27:920-925.
20. Jaffé A, Hamutcu R, Dhawan RT, Adler B, Rosenthal M, Bush A. Routine ventilation scans in children with cystic fibrosis: diagnostic usefulness and prognostic value. Eur J Nucl Med 2001; 28:1313-1318.
21. Bonfield TL, Konstan MW, Berger M. Altered respiratory epithelial cell cytokine production in cystic fibrosis. J Allergy Clin Immunol 1999; 104:72-78.
22. Stecenko AA, King G, Torii K, Breyer RM, Dworski R, Blackwell TS, et al. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation 2001; 25:145-155.
23. Fleming JS, Conway JH, Bolt L, Holgate ST. A comparison of planar scintigraphy and SPECT measurement of total lung deposition of inhaled aerosol. J Aerosol Med 2003; 16:9-19.