Preparation and nucleic acid binding of ellipticine derivatives

Heterocyclic Communications

Volumn 2, Issue 2, 1996, Pages 125-128

  Kennedy, G D ^a   Krishnan, G ^a   Karim, M ^a   Harden, D ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 2542564579     PISSN: 07930283     EISSN: None     Source Type: Journal    
DOI: 10.1515/HC.1996.2.2.125     Document Type: Article

References (9)

1. (a) A.S. Fauci, Science 239, 617-622 (1988);
2. (b) E. De Clercq, in Design of Anti-AIDS Drugs, Ed. E. De Clercq, Elsevier Publishing Company: Amsterdam, pp. 1-24 (1990)
3. W.D. Wilson, G.D. Kennedy, D. Boykin, L. Ratmeyer, M.T. Cegla, J. Spychala, M. Demeunyck, J. Lhomme, G. Krishnan, R. Vinayak and G. Zon, The New Journal of Chemistry 18, 41, 1994
4. (a) C. Auclair, Arch. Biochem. Biophys. 259, 1-14 (1987);
5. (b) M. Schwaller, J. Aubard, G. Dodin, Anti-cancer Drug Design 5, 77-87 (1990);
6. (c) C. Auclair, B. Meunier, B. Dugue and C. Paoletti, Biochemistry 25, 1240-1245 (1986);
7. (d) G. Meunier, D. DeMontauzon, J. Bernadou, G. Grassy, M. Bonnafous, S. Cros and B. Meunier, Mol. Pharmacol. 33, 93-102 (1988)
8. L.M. Werbel, M. Angelo, D.W. Fry and D.F. Worth, J. Med. Chem.. 29, 1321-1322 (1986)
9. The authors wish to thank Dr. W.D. Wilson and Linda Ratmeyer for carrying out the nucleic acid binding studies. ATm values are the Tm (melting temperature) of the nucleic acid-drug complex minus the Tm of the free nucleic acid (see reference 2)