Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: From bench to bedside

Medical Microbiology and Immunology

Volumn 193, Issue 2-3, 2004, Pages 121-126

  Badorff, Cornel ^a,b   Knowlton, Kirk U ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Coxsackievirus B2; Dilated cardiomyopathy; Dystrophin glycoprotein complex; Enterovirus; Myocarditis

Indexed keywords

DYSTROPHIN; SARCOGLYCAN; VIRUS ANTIGEN;

ARTICLE; CASE REPORT; CONGESTIVE CARDIOMYOPATHY; COXSACKIE VIRUS B3; CYTOLYSIS; ENTEROVIRUS INFECTION; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MALE; MUSCLE CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; VIRUS CAPSID; VIRUS MYOCARDITIS;

ADULT; ANIMALS; CARDIOMYOPATHY, DILATED; CYSTEINE ENDOPEPTIDASES; CYTOSKELETAL PROTEINS; DYSTROGLYCANS; DYSTROPHIN; ENTEROVIRUS B, HUMAN; ENTEROVIRUS INFECTIONS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MYOCARDITIS; MYOCARDIUM; RABBITS; SARCOLEMMA; VIRAL PROTEINS;

EID: 2542559620     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-003-0189-7     Document Type: Article

References (21)

1. Baboonian C, Davies MJ, Booth JC, McKenna WJ (1997) Coxsackie B viruses and human heart disease. Curr Top Microbiol Immunol 223:31-52
2. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU (1999) Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med 5:320-326
3. Badorff C, Berkley N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU (2000) Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J Biol Chem 275:1191-1197
4. Badorff C, Fichtlscherer B, Rhoads RE, Zeiher AM, Mülsch A, Dimmeler S, Knowlton KU (2000) Nitric oxide inhibits dystrophin cleavage by Coxsackieviral protease 2A through S-nitrosylation: a protective mechanism against enteroviral cardiomyopathy. Circulation 102:2276-2281
5. Badorff C, Mülsch A, Zeiher AM, Dimmeler S (2002) Selective delivery of nitric oxide to a cellular target: a pseudosubstrate-coupled dinitrosyl iron complex inhibits the enteroviral protease 2A. Nitric Oxide 6:305-312
6. Barresi R, Di Blasi C, Negri T, Brugnoni R, Vitali A, Felisari G, Salandi A, Daniel S, Cornelio F, Morandi L, Mora M (2000) Disruption of heart sarcoglycan complex and severe cardiomyopathy caused by beta sarcoglycan mutations. J Med Genet 37:102-107
7. Beggs AH (1997) Dystrophinopathy, the expanding phenotype. Dystrophin abnormalities in X-linked dilated cardiomyopathy. Circulation 95:2344-2347
8. Blom N, Hansen J, Blaas D, Brunak S (1996) Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks. Protein Sci 5:2203-2216
9. Chen J, Chien KR (1999) Complexity in simplicity: monogenic disorders and complex cardiomyopathies. J Clin Invest 103:1483-1485
10. Fadic R, Sunada Y, Waclawik AJ, Buck S, Lewandoski PJ, Campbell KP, Lotz BP (1996) Brief report: deficiency of a dystrophin-associated glycoprotein adhalin in a patient with muscular dystrophy and cardiomyopathy. N Engl J Med 334:362-366
11. Graham RM, Owens WA (1999) Pathogenesis of inherited forms of dilated cardiomyopathy. N Engl J Med 341:1759-1762
12. Knowlton KU, Badorff C (1999) The immune system in viral myocarditis: maintaining the balance. Circ Res 85:559-561
13. Lee GH, Badorff C, Knowlton KU (2000) Dissociation of sarcoglycans and the dystrophin carboxl terminus from the sarcolemma in enteroviral cardiomyopathy. Circ Res 876: 489-495
14. Li Y, Bourlet T, Andreoletti L, Mosnier JF, Peng T, Yang Y, Archard LC, Pozzetto B, Zhang H (2000) Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 101:231-234
15. Martino TA, Liu P, Sole MJ (1994) Viral infection and the pathogenesis of dilated cardiomyopathy. Circ Res 74:182-188
16. Melacini P, Fanin M, Danieli GA, Villanova C, Martinello F, Miorin M, Freda MP, Miorelli M, Mostacciuolo ML, Fasoli G, Angelini C, Dalla Volta S (1996) Myocardial involvement is very frequent among patients affected with subclinical Becker's muscular dystrophy. Circulation 94:3168-3175
17. Oldstone MBA (1998) Viruses, plaques and history. Oxford University Press, New York
18. Towbin JA (1998) The role of cytoskeletal proteins in cardiomyopathies. Curr Opin Cell Biol 10:131-139
19. Wessely R, Henke A, Zell R, Kandolf R, Knowlton KU (1998) Low level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes. Circulation 98: 450-457
20. Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Lederer JW, Kandolf R, Knowlton KU (1998) Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J Clin Invest 102:1444-1453
21. Xiong D, Lee GH, Badorff C, Lee S, Wolf P, Knowlton KU (2002) Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med 8:872-877