Thymic volume is associated independently with the magnitude of short- and long-term repopulation of CD4+ T cells in HIV-infected adults after highly active antiretroviral therapy (HAART)

Clinical and Experimental Immunology

Volumn 136, Issue 3, 2004, Pages 501-506

  Ruiz Mateos, E ^a   Rubio, A ^a,b   Vallejo, A ^a   De La Rosa, R ^a   Sanchez Quijano, A ^a   Lissen, E ^a   Leal, M ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

CD4+; HAART; HIV; Thymic function; TREC

Indexed keywords

ADULT; CELL COUNT; CELL POPULATION; CELL SUBPOPULATION; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; THYMUS FUNCTION;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTE COUNT; MALE; RNA, VIRAL; THYMUS GLAND; TOMOGRAPHY, X-RAY COMPUTED; VIRAL LOAD;

EID: 2542554963     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02474.x     Document Type: Conference Paper

References (37)

1. Connick E, Lederman MM, Kotzin BL et al. Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis 2000; 181:358-63.
2. Wu H, Kuritzkes DR, McClernon DR et al. Characterization of viral dynamics in human immunodeficiency virus type-1 infected patients treated with combination antiretroviral therapy. J Infect Dis 1999; 179:799-807.
3. Viard JP, Mocroft A, Chiesi A et al. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis 2001; 183:1290-4.
4. Cohen Stuart JW, Hamann D, Borleffs J et al. Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age. AIDS 2002; 16:2263-6.
5. Smith KY, Valdez H, Landay A et al. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis 2000; 181:141-7.
6. Vigano A, Vella S, Saresella M et al. Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus. AIDS 2000; 14:251-61.
7. Franco JM, Rubio A, Martinez-Moya M et al. T cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy. Blood 2002; 99:3702-6.
8. Texeira L, Valdez H, McCune J et al. Poor CD4T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001; 15:1749-56.
9. + T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy. Antivir Ther 2002; 7:159-63.
10. + T cell repopulation in adult HIV-infected patients on HAART. Antiviral Ther 2003; 8:289-94.
11. + count cell depletion and progression to AIDS. Ann Intern Med 1993; 118:681-8.
12. Zaitseva MB, Lee S, Rabin RL et al. CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection. J Immunol 1998; 161:3103-13.
13. Ruiz-Mateos E, de la Rosa R, Franco JM et al. Endogenous interleukin-7 is associated with increased thymic volume in adult HIV-infected patients under HAART. AIDS 2003; 17:947-54.
14. Choyke PL, Zeman RK, Gootenberg J, Greenberg JN, Hoffer F, Frank JA. Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Am J Roentgenol 1987; 149:269-72.
15. + T-lymphocytes regeneration after antiretroviral therapy in HIV-1 infected children and adult patients. Clin Exp Immunol 2000; 119:493-8.
16. Douek DC, McFarland RD, Keiser PH et al. Changes in thymic function with age and during treatment of HIV infection. Nature 1998; 396:690-5.
17. Simmons G, Wilkinson D, Reeves JD et al. Primary, syncitium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as co-receptors for virus entry. J Virol 1996; 70:8355-60.
18. + mature thymocytes correlates with their capacity to favor human immunodeficiency X4 virus replication. J Virol 2003; 77:5784-93.
19. + T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995; 332:143-9.
20. Clerici M, Saresella M, Trabattoni D, Ferrante P, Vanzulli A, Vigano A. Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy. AIDS 2002; 16:2219-27.
21. Pakker NG, Notermans DW, de Boer RJ et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 1998; 4:208-14.
22. + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999; 103:1391-8.
23. Landay AL, Bettendorf D, Chan E et al. Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease. AIDS Res Hum Retrov 2002; 18:95-102.
24. Rubio A, Martinez-Moya M, Leal M et al. Changes in thymus volume in adult HIV-infected patients under HAART: correlation with the T cell repopulation. Clin Exp Immunol 2002; 1:121-6.
25. + cell kinetic patterns and their relationships with baseline factors and virological responses in HIV type 1 patients receiving highly active antiretroviral therapy. AIDS Res Hum Retrov 2001; 17:1231-40.
26. Bonyhadi ML, Rabin L, Salimi S et al. HIV induces thymus depletion in vivo. Nature 1993; 363:690-5.
27. Kaneshima H, Su L, Bonyhadi ML, Connor RI, Ho DD, McCune JM. Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse. J Virol 1994; 68:8188-92.
28. Su L, Kaneshima H, Bonyhadi M et al. HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo. Immunity 1995; 2:25-36.
29. Kollmann TR, Kim A, Pettoello-Mantovani M et al. Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 1995; 154:907-21.
30. Kitchen SG, Zack JA. CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus. J Virol 1997; 71:6928-34.
31. Berkowitz RD, Beckerman K, Pk Schall TJ, McCune JM. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. J Immunol 1998; 161:3702-10.
32. Taylor JR, Kimbrell K, Scoggins R, Delaney M, Wu L, Camerini D. Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type-1. J Virol 2001; 75:8752-60.
33. Pedroza-Martins L, Boscardin WJ, Anisman-Posner DJ, Schols D, Bryson YJ, Uittenbogaart CH. Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants. J Virol 2002; 76:6929-43.
34. Piroth L, Duong M, Quantin C et al. Does hepatitis C virus co-infection accelerate clinical and immunologjcal evolution of HIV-infected patients? AIDS 1998; 5:381-8.
35. Sulkowski MS, Moore RD, Mehta SH, Chaisson RE, Thomas DL. Hepatitis C and progression of HIV disease. JAMA 2002; 288:199-206.
36. Greub G, Ledergerber B, Battegay M et al. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet 2000; 356:1800-5.
37. De Luca A, Bugarni R, Lepri AC et al. for the Italian Cohort Naive Antiretrovirals Study Group. Coinfection with hepatitis viruses and outcome of initial antiretroviral regimens in previously naive HIV-infected subjects. Arch Intern Med 2002; 162:2125-32.