Age-dependent Changes in Cardiovascular and Metabolic Responses to Exercise in Beagle Dogs

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 44, Issue 8, 1997, Pages 449-460

  Strasser, A ^a   Simunek, M ^a   Seiser, M ^b   Hofecker, G ^a  

^a VMU Wien   (Austria)

^b I Clin Horses and Small Animals   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 2542521567     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0442.1997.tb01130.x     Document Type: Article

References (41)

1. ABRASS, I. B., J. L. DAIS, and P. J. SCARPACE, 1982: Isoproterenol responsiveness and myocardial ß-adrenergic receptors in young and old rats. J. Gerontol. 37, 156-160.
2. BONAGURA, J D., 1981: Cardiopulmonary disorders in the geriatric dog Vet. Clin. North Am. (Small Anim. Pract.) 11, 705-726.
3. DAVY, K.P., D.G. JOHNSON, and D.R. SEALS, 1995: Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans. Clin. Physiol. 15, 169-181.
4. DOBSON, G. P., W.S. PARKHOUSE, J.M. WEBER, E. STUTTARD, J. HARMAN, D.H. SNOW, and P.W. HOCHACHKA, 1988: Metabolic changes in skeletal muscle and blood of greyhounds during 800-m track sprint. Am. J. Physiol. 255, R513-R519.
5. FLEG, J.L., F. O'CONNOR, G. GERSTENBLITH, L.C. BECKER, J. CLULOW, S.P. SCHULMAN, and E.G. LAKATTA, 1995: Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J. Appl Physiol. 78, 890-900.
6. FROLKIS, V.V., V.V. BEZRUKOV, L.N. BOGATSKAYA, N.S. VERKHRATSKY, V.P. ZAMOSTIAN, V.G. SHEVTCHUK, and I.V. SHTCHEGOLEVA, 1979: Catecholamines in the metabolism and functions regulation in old age. Gerontologia 16, 129-140
7. th edn. Appleton and Lange, Norwalk, Connecticut.
8. HAIDET, G. C., 1989: Dynamic exercise in senescent beagles: oxygen consumption and hemodynamic responses Am. J. Physiol. 257, H1428-H1437.
9. HAIDET, G. C., 1992: Effect of age on cardiovascular responses to static muscular contraction in beagles. J. Appl. Physiol. 73, 2320-2327.
10. HAIDET, G. C., 1993: Alpha-adrenergic-mediated reflex responses to induced muscular contraction are changed with age in dogs. Am. J. Physiol. 265, H1899-H1908.
11. HAIDET, G.C., and D. PARSONS, 1991: Reduced exercise capacity in senescent beagles: an evaluation of the periphery. Am. J. Physiol. 260, H173-H182.
12. HAMLIN, R.L., 1990: Identifying the cardiovascular and pulmonary diseases that effect older dogs. Vet. Med. 85, 483-497.
13. HERRTAGE, M. E., 1990: Management of the geriatric dog. Vet. Ann. 30, 203-210.
14. ILKIW, J. E., P.E. DAVIS, and D.B. CHURCH, 1989: Hematologic, biochemical, blood-gas, and acid-base values in greyhounds before and after exercise. Am. J. Vet. Res. 50, 583-586
15. KENNEY, R.A., 1982: Physiology of Aging. A Synopsis. Yearbook Medical Publishers, Inc., Chicago-London.
16. KRAFT, W., A. TRIMBORN, U. PAULING, and P. BEELITZ., 1990: Altersmultimorbidität bei Hund und Katze. Tierärztl. Prax. 18, 184-191.
17. LAKATTA, E.G., 1993. Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73, 413-467.
18. 2-consumption during exercise in dogs - roles of splenic contraction and α-adrenergic vasoconstriction. Am. J. Physiol. 251, H502-H509.
19. MAHER, E. R., J.E. RUSH, 1990: Cardiovascular changes in the geriatric dog. Comp. Cont. Educ. Pract. Vet. 12, 921-931.
20. MANGIACAPRA, F. J., and J. R. FLORINI, 1990: Alterations in Hormone Syntheses and Secretion with Age. In: ARMBRECHT, H J., and N. WONGSURAWAT (eds) Endocrine Function and Aging, pp. 13-25. Springer Verlag, New York
21. MARIN, J., 1995: Age-related changes in vascular response: a review. Mech. Age. Dev. 79, 71-114.
22. MAUDERLY, J.L., and Ff. HAHN, 1982: The effect of age on lung structure and function of adult animals. Adv. Vet. Sci. Comp. Med. 26, 35-77.
23. MOSIER, J. E., 1989: Effect of aging on body systems of the dog. Vet Clin. North. Am. Small Anim. Pract 19, 1-12.
24. OHHARA, Y., K. SAKURADA, T. MIYAZAKI, and I. SUGIMURA, 1994: Longitudinal assessment of hematological parameters in the elderly, Nippon Ronen Igakkai Zasshi 31, 548-553.
25. RAVEN, P. B., and J. MITCHELI., 1980: The effect of aging on the cardiovascular response to dynamic and static exercise In: WEISFELDT, M.L. (ed.) The aging heart, pp. 269-296. Raven Press, New York.
26. HOSKINS, J.D., 1995: The cardiovascular system. In: RUSH, J.E., L.M. FREEMAN, R.T. GOLDSTON (eds) Geriatrics and gerontology of the dog and cat, pp. 89-115. W.B. Saunders, Philadelphia, USA.
27. SAKUMA, A., I TSCBOI, K. MORIMOTO, T. HORIE, K. SUGIMOTO, and K.J. MORI, 1994: Age-related decreases in the reconstituting ability of hemopoetic cells and the ability of hemopoetic microinvironment to support hemopoetic reconstitution in senescence accelerated (SAM-P) mice. Mech Ageing Dev. 73, 127-135.
28. SANDERSLEBEN, J-V., E. SCHAFFER, and J. WEISSF., 1973. Erkrankungs- und Todesursachen des alternden Hundes aus der Sicht der Sektionsdiagnostik. Kleintierpraxis 18, 25-56.
29. SCARPACE, P. J., and I.B. ABRASS, 1983: Decreased beta-adrenergic agonist affinity and adenylate cyclase activity in senescent rat lung. J. Gerontol. 38, 143-147.
30. SCARPACE, P. J., and I.B. ABRASS, 1986: Beta-adrenergic agonist-mediated desensitisation in senescent rats. Mech. Ageing Dev. 35, 255-264.
31. SIGAI., R.J., S. FISHER, J.B. HALTER, M. VRANIC, and E.B. MARLISS, 1996: The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique. Diabetes 45, 148-156.
32. STRASSER, A., M. SEISER, M. SIMUNEK, V. HEIZMANN, and H. NIEDERMULLER, 1997: Physiologische Altersveranderungen beim Hund (Longitudinalstudie in einer Beagleskohorte). Wiener Tierärztliche Monatsschrift 84, 189-198.
33. STRATTON, J R., M.D. CERQUERIRA, R.S. SCHWARTZ, W.C. LEVY, R.C. VEITH, S.E. KAHN, and I.B. ABRASS, 1992: Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation 86, 504-512.
34. TAYLOR, J.A., J. HAYANO, and D.R. SEALS, 1995: Lesser vagal withdrawal during isometric exercise with age. J. Appl. Physiol. 79, 805-811.
35. TIPTON, C.M., R.A. CAREY, W.C. EASTIN, and H.H. ERICKSON, 1974: A submaximal test for dogs: evaluation of effects of training, detraining, and cage confinement. J. Appl. Physiol. 37, 271-275.
36. TUMER, N., W.T. HOUCK, and J. ROBERTS, 1990: Effect of age on upregulation of the cardiac adrenergic beta receptors. J. Gerontol. 45, B48-B51.
37. WASSERMAN, D.H., 1995: Regulation of glucose fluxes during exercise in the postabsorptive state. Annu. Rev. Physiol. 57, 191-218.
38. YAMANE, Y., 1991: Canine and feline cardiovascular abnormalities in old age: mitral insufficiency. J. Vet. Med. A 44, 349-355.
39. YIN, F. C. P., H.A. SPURGEON, G.S. RAIZES, H.L. GREEN, M. L. WEISFELDT, and N.W. SHOCK, 1976: Age-assosiated decrease in chrontropic response to isoproterenol (Abstract). Circulation 4, 161-167.
40. YIN, F. C. P., H.A. SPURGEON, H. L. GREENE, E.G. LAKATTA, and M.L. WEISFELDT, 1979: Age-associated decrease in heart rate response to isoproterenol in dogs. Mech. Ageing Dev. 10, 17-25.
41. YIN, F. C. P., M.L. WEISFELDT, and W.R. MILNOR, 1981: Role of aortic input impedance in the decreased cardiovascular response to exercise with aging in dogs. J. Clin. Invest. 68, 28-38.