Sex differences in stereospecificity of oracin reductases in rat in vitro and in vivo

Chirality

Volumn 11, Issue 5-6, 1999, Pages 505-509

  Wsól, Vladimír ^a   Skálová, Lenka ^a   Szotáková, Barbora ^a   Trejtnar, František ^a   Kvasničková, Eva ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Carbonyl reductase; Chiral HPLC; Chiralcel OD R; Cytosol; Cytostatic drug; Enantiomeric resolution; Hepatocytes; Microsomes

Indexed keywords

11 DIHYDROORACIN; CARBONYL REDUCTASE; CYTOSTATIC AGENT; ORACIN; ORACIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; BIOTRANSFORMATION; CHIRAL CHROMATOGRAPHY; CHIRALITY; CONFERENCE PAPER; CONTROLLED STUDY; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER CYTOSOL; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STEREOISOMERISM; STEREOSPECIFICITY;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CYTOSOL; ETHANOLAMINES; FECES; FEMALE; ISOQUINOLINES; LIVER; MALE; MICROSOMES, LIVER; RATS; SEX CHARACTERISTICS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 2542507777     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:5/6<505::AID-CHIR25>3.0.CO;2-5     Document Type: Conference Paper

References (17)

1. Michalský J. International Patent Application No. PCT/CS92/00026, 1992.
2. Mělka M. Screening evaluation. Research Report RIPB, 1987.
3. Szotáková B, Wsól V, Trejtnar F, Skálová L, Kvasničková E. Studies on the metabolism of the potential cytostatic drug oracin. Species differences. Exp Toxicol Pathol 1996;48(Suppl. II):377-380.
4. Wsól V, Kvasničková E, Szotáková B, Hais IM. High-performance liquid chromatographic assay for the separation and characterization of metabolites of the potential cytostatic drug oracin. J Chromatogr B 1996;681:169-175.
5. Pryde A. Chiral liquid chromatography: past and present. In: Lough WJ, editor. Chiral liquid chromatography. New York: Chapman and Hall; 1989. p 23-35.
6. Brain K, Rao KRN, Lloyd MJB. Novel chiral stationary phases. In: Krstulovic AM, editor. Chiral separation by HPLC. Chichester: John Wiley & Sons, Inc.; 1989. p 10-537.
7. Adamovics JA, Farb DL. High-performance liquid chromatography. In: Adamovics JA, editor. Chromatographic analysis of pharmaceuticals. New York: Marcel Dekker, Inc.; 1997. p 135-207.
8. Testa B. Dehydrogenation of alcohols and aldehydes, carbonyl reduction. In: Testa B, editor. The metabolism of drugs and other xenobiotics: Biochemistry of redox reactions. London: Academic Press Limited; 1995. p 41-69.
9. Bachur NR. Cytoplasmic aldo-keto reductases: A class of drug metabolizing enzymes. Science 1976;193:595-597.
10. Felsted RL, Bachur NR. Mammalian carbonyl reductases. Drug Metab Rev 1980;11:1-60.
11. Davankov V. The nature of chiral recognition: Is it a three-point interaction? Chirality 1997;9:99-102.
12. Ariëns EJ. Racemates: An impediment in the use of drugs and agrochemicals. In: Krstulovic AM, editor. Chiral separation by HPLC. Chicester: John Wiley & Sons, Inc.; 1989. p 31-68.
13. Mason JP, Hutt AJ. Stereochemical aspects of drug metabolism. In: Aboul-Enein HY, Wainer IW, editors. The impact of stereochemistry on drug develoment and use. New York: John Wiley & Sons, Inc.; 1997. p 45-105.
14. Wsól V, Szotáková B, Kvasničková E, Fell Af. High-performance liquid chromatography study of stereospecific microsomal enzymes catalysing the reduction of a potential cytostatic drug, oracin. Interspecies comparison. J Chromatogr A 1998;797:197-201.
15. Gillete JR. Techniques for studying drug metaboism in vitro. In: La Du BN, Mandel HG, Way EL, editors. Fundamentals of drug metabolism and drug disposition. Baltimore: The Williams & Wilkins Company; 1971. p 400-418.
16. Moldéus P, Högberg J, Orrenius S. Isolation and use of liver cells. Methods Enzymol 1978;52:60-71.
17. Goeptar AR, Scheerens H, Vermeulen PE. Oxygen and xenobiotic reductase activities of cytochrome P450. Crit Rev Toxicol 1995;25:25-65.