ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer

European Archives of Oto-Rhino-Laryngology

Volumn 261, Issue 5, 2004, Pages 262-266

  Csanády, Miklos ^a   Kiss, József G ^a   Iván, Lászlo ^a   Jóri, József ^a   Czigner, Jeno ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

ALA induced protoporphyrin accumulation; Endoscopic detection; Pharyngeal and laryngeal cancer; Tumour selective fluorescence

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ADULT; ARTICLE; AUTOFLUORESCENCE; BENIGN TUMOR; CANCER DIAGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENDOSCOPY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN TISSUE; HYPOPHARYNX TUMOR; LARYNX CANCER; LASER SURGERY; MICROSCOPY; PHARYNX CANCER; PRIORITY JOURNAL;

ADULT; AGED; AMINOLEVULINIC ACID; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLUORESCENCE; HUMANS; LARYNGEAL NEOPLASMS; LARYNGOSCOPY; LASER SURGERY; MALE; MIDDLE AGED; NEOPLASM STAGING; PHARYNGEAL NEOPLASMS; PHOTOSENSITIZING AGENTS; PRECANCEROUS CONDITIONS; PROSPECTIVE STUDIES; PROTOPORPHYRINS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 2542480986     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-003-0660-5     Document Type: Article

References (16)

1. Betz CS, Mehlmann M, Rick K, Stepp H, Grevers G, Baumgartner R, Leunig A (1999) Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer. Lasers Surg Med 25:323-334
2. 2 laser microsurgery of early vocal cord cancer. A retrospective study. Adv Otorhinolaryngol Lasers in Otorhinolaryngol Head and Neck Surg. Karger, Basel, pp 219-221
3. Czigner J, Sávay L (1994) Endoscopic CO2 laser surgery for vocal cord cancer. Diagn Ther Endosc 1:69-74
4. Hillemanns P, Weingandt H, Baumgartner R, Diebold J, Xiang W (2000) Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acid-induced porphyrin fluorescence. Cancer 88:2275-2282
5. Kennedy J, Pottier R, Pross R (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol 6:143-148
6. Krieg RC, Fickweiler S, Wolfbeis OS, Knuechel R (2000) Cell-type specific protoporphyrin metabolism in human bladder cancer. Photochem Photobiol 72:226-233
7. Lang S, Baumgartner R, Struck R, Leunig A, Gutmann R, Feyh J (1995) Photodynamic diagnosis and therapy of neoplasms of the facial skin after topical administration of 5-aminolevulinic acid. Laryngorhinootologie 74:85-89
8. Leunig A, Betz CS, Baumgartner R (2000) Initial experience in the treatment of oral leukoplakia with high dose vitamin A and follow up 5-aminolevulinic acid induced protoporphyrin IX fluorescence. Eur Arch Otorhinolaryngol 257:327-331
9. Leunig A, Betz CS, Mehlmann M (2000) Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. Laryngoscope 110:78-83
10. Leunig A, Mehlmann M, Betz C (2001) Fluorescence staining of oral cancer using topical application of 5-aminolevulinic acid: fluorescence microscopic studies. J Photochem Photobiol 60:44-49
11. Mehlmann M, Betz CS, Stepp H (1999) Fluorescence staining of laryngeal neoplasms after topical application of 5-aminolevulinic acid: preliminary results. Lasers Surg Med 25:414-420
12. Monnier P, Savary M, Fontoillet C (1990) Photodetection and photodynamic therapy of "early" squamous cell carcinoma of the pharynx, oesophagus and tracheobronchial tree. Laser Med Sci 5:149-169
13. Riedl R, Daniltchenko D, Koenig F (2001) Fluorescence endoscopy with 5-aminolevulinic acid reduces recurrences rate in superficial bladder cancer. J. Urol 165:1121-1123
14. Rubino G, Rasetti L (1966). Porphyrin metabolism in human neoplastic tissue. Panminerva Med 8:290-292
15. Zaak D, Kriegmair M, Stepp H (2001) Endoscopic detection of transitional cell carcinoma with 5 aminolevulinioc acid: results of 1,012 fluorescence endoscopies. Urology 57:690-694
16. Zheng W, Soo KC, Sivanandan R (2002) Detection of neoplasms in the oral cavity by digitalized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. Int J Oncol 21:763-768