Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokines

Cancer Immunology, Immunotherapy

Volumn 53, Issue 6, 2004, Pages 543-550

  Takahashi, Akihiro ^a   Kono, Koji ^a   Ichihara, Fumiko ^a   Sugai, Hidemitsu ^a   Fujii, Hideki ^a   Matsumoto, Yoshiro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Apoptosis; Costimulatory molecule; Dendritic cells; Gastric carcinoma; Vascular endothelial growth factor

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; LIPOCORTIN 5; LIPOPOLYSACCHARIDE; PROPIDIUM IODIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DENSITY; CELL INFILTRATION; CELL MATURATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DENDRITIC CELL; DOSE RESPONSE; DOWN REGULATION; EVALUATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; STOMACH CARCINOMA; T LYMPHOCYTE;

ADENOCARCINOMA; ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DENDRITIC CELLS; DINOPROSTONE; DOWN-REGULATION; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-12; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; OXYTOCICS; PHENOTYPE; STOMACH NEOPLASMS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 2542470851     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-003-0466-8     Document Type: Article

References (26)

1. Choux P, Favre N, Martin M, Martin F (1997) Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats. Int J Cancer 72:619
2. Gabrilovich DI, Corak J, Ciernik IF, Kavanaugh D, Carbone DP (1997) Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res 3:483
3. Enk AH, Jonuleit H, Saloga J, Knop J (1997) Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma Int J Cancer 73:309
4. Almand B, Resser JB, Lindman B, Nadarf S, Clark JI, Kwon ED, Carbone DP, Gabrilovich DI (2000) Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res 6:1755
5. Tsujitani S, Furukawa T, Tamada R, Okamura T, Yasumoto K, Sugimachi K (1987) Langerhans cells and prognosis in patients with gastric cancer. Cancer 59:501
6. Furukawa T, Watanabe S, Kodama T, Sato Y, Shimosato Y, Suemasu K (1985) T-zone histiocytes in adenocarcinoma of the lung in relation to postoperative prognosis. Cancer 56:2651
7. Ambe K, Mori M, Enjoji M (1989) S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Cancer 63:496
8. Matsuda H, Mori M, Tsujitani S, Ohno S, Kuwano H, Sugimachi K (1990) Immunohistochemical evaluation of squamous cell carcinoma antigen and S-100 protein-positive cells in human esophageal tissues. Cancer 65:2261
9. Nakano T, Oka K, Arai T, Morita S, Tsunemoto H (1989) Prognostic significance of Langerhans' cell infiltration in radiation therapy for squamous cell carcinoma of the uterine cervix. Arch Pathol Lab Med 113:507
10. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306
11. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J (1989) Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470
12. Kaya M, Wada T, Akatsuka T, Kawaguchi S, Nagoya S, Shindoh M, Higashino F, Mezawa F, Okada F, Ishii S (2000) Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res 6:572
13. Saito H, Tsujitani S, Ikeguchi M, Maeta M, Kaibara N (1998) Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue. Br J Cancer 78:1573
14. Miyake M, Taki T, Hitomi S, Hakomori S (1992) Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung. N Engl J Med 327:14
15. Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D, Carbone DP (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 2:1096
16. Gabrilovich DI, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, Carbone DP (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92:4150
17. Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, Gabrilovich DI (1998) Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hematopoietic progenitor cells. J Immunol 160:1224
18. Ishida T, Oyama T, Carbone DP, Gabrilovich DI (1998) Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hematopoietic progenitors. J Immunol 161:4842
19. Takahashi A, Kono K, Itakura J, Amemiya H, Tang RF, Iizuka H, Fujii H, Matsumoto Y (2002) Correlation of vascular endothelial growth factor-C expression with tumor-infiltrating dendritic cells in gastric cancer. Oncology 62:121
20. + dendritic cells. Proc Natl Acad Sci U S A 93:2588
21. Dhodapkar KM, Krasovsky J, Williamson B, Dhodapkar MV (2002) Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells. J Exp Med 195:125
22. Takahashi A, Kono K, Amemiya H, Iizuka H, Fujii H, Matsumoto Y (2001) Elevated caspase activity in peripheral blood T cells coexists with increased degree of T-cell apoptosis and down-regulation of TCRζmolecules in patients with gastric cancer. Clin Cancer Res 7:74
23. Tsujitani S, Kakeji Y, Watanabe A, Kohnoe S, Maehara Y, Sugimachi K (1990) Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer. Cancer 66:2012
24. Maehara Y, Tomisaki S, Oda S, Kakeji Y, Tsujitani S, Ichiyoshi Y, Akazawa K, Sugimachi K (1997) Lymph node metastasis and relation to tumour growth potential and local immune response in advanced gastric cancer. Int J Cancer 74:224
25. Kiertscher SM, Luo J, Dubinett SM, Roth MD (2000) Tumors promote althered maturation and early apoptosis of monocyte-derived dendritic cells. J Immunol 164:1269
26. Ohm JE, Carbone DP (2001) VEGF as a mediator of tumor-associated immunodeficiency. Immunol Res 23:263