Severe coagulopathy following intraoperative use of topical thrombin

Annals of Vascular Surgery

Volumn 18, Issue 3, 2004, Pages 349-351

  Sarfati, Mark R ^a   DiLorenzo, Daniel J ^b   Kraiss, Larry W ^a   Galt, Spencer W ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN; PREDNISONE; THROMBIN;

AGED; ANTIBODY PRODUCTION; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; CASE REPORT; CATTLE; CLINICAL FEATURE; CONTAMINATION; DISEASE COURSE; DISEASE SEVERITY; DRUG EXPOSURE; HUMAN; INTRAOPERATIVE PERIOD; MALE; PLASMAPHERESIS; PRIORITY JOURNAL; SURGEON; TREATMENT OUTCOME;

EID: 2542447341     PISSN: 08905096     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10016-004-0028-3     Document Type: Article

References (7)

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2. Rapaport SI, Zivelin A, Minow RA, Hunter CS, Donnelly K. Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin. Am. J. Clin. Pathol. 1992;97:84-91.
3. Nesheim ME, Nichols WL, Cole TL, et al. Isolation and study of an acquired inhibitor of human coagulation factor V. J. Clin. Invest. 1986;77:405-415.
4. Flaherty MJ, Henderson, Wener MH. Iatrogenic immunization with bovine thrombin: a mechanism for prolonged thrombin times after surgery. Ann. Intern. Med. 1989; 111:631-634.
5. Neschis DG, Heyman MR, Cheanvechai V, Benjamin ME, Flinn WR. Coagulopathy as a result of factor V inhibitor after exposure to bovine topical thrombin. J. Vasc. Surg. 2002; 35:400-402.
6. Muntean W, Zenz W, Finding K, Zobel G, Beitzke A. Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two-year-old child. Acta Paediatr. 1994;83:84-87.
7. Chediak J, Ashenhurst JB, Garlck I, Desser RK. Successful management of bleeding in a patient with factor V inhibitor by platelet transfusions. Blood 1980;56:835.