Isomers of trans fatty acids modify the activity of platelet 12-P lipoxygenase and cyclooxygenase/thromboxane synthase

Nutrition

Volumn 20, Issue 6, 2004, Pages 570-571

  Stachowska, Ewa ^a   Dolȩgowska, Barbara ^a   Olszewska, Maria ^a   Gutowska, Izabela ^a   Chlubek, Dariusz ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

12 P lipoxygenase; cyclooxygenase; thromboxane synthase; trans fatty acids

Indexed keywords

ELAIDIC ACID; FATTY ACID; LINOLEIC ACID; LIPOXYGENASE; MONOUNSATURATED FATTY ACID; OLEIC ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN SYNTHASE; THROMBOXANE SYNTHASE;

ARTICLE; BLOOD SAMPLING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; TRANS ISOMER;

BLOOD PLATELETS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; ISOMERISM; LIPOXYGENASE; PLATELET ACTIVATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REFERENCE VALUES; THROMBOXANE-A SYNTHASE; TRANS FATTY ACIDS;

EID: 2542435957     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2004.03.013     Document Type: Article

References (11)

1. Willett W.C., Ascherio A. Trans fatty acids are the effects only marginal? Am J Public Health. 84:1994;722
2. Truitt A., McNeill G., Vanderhoek J.Y. Antiplatelet effects of conjugated linoleic acid isomers. Biochim Biophys Acta. 1438:1999;239
3. MacIntyre D.E., Hoover R.L., Smith M., et al. Inhibition of platelet function by cis-unsaturated fatty acids. Blood. 63:1984;848
4. Torres-Duarte A., Vanderhoek J.Y. Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. Biochim Biophys Acta. 1640:2003;69
5. Hamberg M., Svensson J., Samuelsson B. Thromboxanes a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA. 72:1975;2994
6. Buchanan M.R., Horsewood P., Brister S.J. Regulation of endothelial cell and platelet receptor-ligand binding by 12- and 15-lipoxygenase monohydroxides, 12, ins 15-HETE and 13-HODE. Prostagland-Leukot Essent Fatty Acids. 8:1998;339
7. Anthon G.E., Barrett D.M. Colorimetric method for the determination of lipoxygenase activity. J Agric Food Chem. 49:2001;32
8. 2 as a mechanism for the anti-aggregating effect of linoleic acid. Agents Actions. 10:1980;57
9. Gerrard J.M., White J.G., Krivit W. Labile aggregation stimulating substance, free fatty acids, and platelet aggregation. J Lab Clin Med. 87:1976;73
10. Katz A.M. Trans-fatty acids and sudden cardiac death. Circulation. 105:2002;669
11. Pace-Asciak C., Wolfe L.S. Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids. Biochim Biophys Acta. 152:1968;784