Ductuloinsular tumors of the pancreas: Endocrine tumors with entrapped nonneoplastic ductules

American Journal of Surgical Pathology

Volumn 28, Issue 6, 2004, Pages 813-820

  Van Eeden, Susanne ^a   De Leng, Wendy W J ^a   Offerhaus, G Johan A ^a   Morsink, Folkert H ^a   Weterman, Marian A J ^a   De Krijger, Ronald R ^b   Klöppel, Günter ^c   Klimstra, David S ^d  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Endocrine tumor; KRAS; Pancreas; PDX 1; X chromosome inactivation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; PROTEIN P53; SMAD4 PROTEIN; TRANSCRIPTION FACTOR PDX 1;

ADULT; AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; CLONAL VARIATION; CODON; ENDOCRINE TUMOR; FEMALE; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPH NODE METASTASIS; MALE; MOLECULAR GENETICS; PANCREAS DUCT; PANCREAS DUCTULOINSULAR TUMOR; PANCREAS RESECTION; PANCREAS TUMOR; SEQUENCE ANALYSIS; SYMPTOM; X CHROMOSOME INACTIVATION;

ADULT; DNA-BINDING PROTEINS; FEMALE; GENES, ERBB-2; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM METASTASIS; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; SMAD4 PROTEIN; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2542435230     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000112546.57641.c7     Document Type: Article

References (22)

1. Bahary N, Zon LI. Endothelium: chicken soup for the endoderm. Science. 2001;294:530-531.
2. Deshpande V, Selig MK, Nielsen GP, et al. Ductulo-insular pancreatic endocrine neoplasms: clinicopathological analysis of a unique subtype of pancreatic endocrine neoplasms. Am J Surg Pathol. 2003;27:461-468.
3. Entius MM, Keller JJ, Drillenburg P, et al. Microsatellite instability and expression of hMLH-1 and hMSH-2 in sebaceous gland carcinomas as markers for Muir-Torre syndrome. Clin Cancer Res. 2000;6:1784-1789.
4. Fischer C, Büthe J, Nollau P, et al. Enrichment of mutant KRAS alleles in pancreatic juice by subtractive iterative polymerase chain reaction. Lab Invest. 2001;81:827-831.
5. Furlan D, Cerutti R, Genasetti A, et al. Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collission endocrine-exocrine tumors of the gut. Lab Invest. 2003;83:963-971.
6. Going JJ. Epithelial carcinogenesis: challenging monoclonality. J Pathol. 2003;200:1-3.
7. Hoet JJ, Reusens B, Remacle C. Anatomy, developmental biology, and pathology of the pancreatic islets. In: DeGroot LJ, ed. Endocrinology, 3rd ed. Philadelphia: Saunders, 1995:1277-1289.
8. Hruban RH, Wilentz RE, Kern SE. Genetic progression in the pancreatic ducts. Am J Pathol. 2000;156:1821-1825.
9. Kamisawa T, Tu Y, Egawa N, et al. Ductal and acinar differentiation in pancreatic endocrine tumors. Dig Dis Sci. 2002;47:2254-2261.
10. Klimstra DS, Rosai J, Heffess CS. Mixed acinar-endocrine carcinomas of the pancreas. Am J Surg Pathol. 1994;18:765-778.
11. Klöppel G. Mixed exocrine-endocrine tumors of the pancreas. Semin Diagn Pathol. 2000;17:104-108.
12. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001;294:564-567.
13. Nonomura A, Kono N, Mizukami Y, et al. Duct-acinar-islet cell tumor of the pancreas. Ultrastruct Pathol. 1992;16:317-329.
14. Novelli M, Cossu A, Oukrif D, et al. X-inactivation patch size in humane female tissue confounds the assessment of tumor clonality. Proc Natl Acad Sci USA. 2003;100:3311-3314.
15. Ohike N, Jürgensen A, Pipeleers-Marichal M, et al. Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells. Virchows Arch. 2003;442:258-265.
16. Peters J, Jürgensen A, Klöppel G. Ontogeny, differentiation and growth of the endocrine pancreas. Virchows Arch. 2000;436:527-538.
17. Regitnig P, Spuller E, Denk H. Insulinoma of the pancreas with insular-ductular differentiation in its liver metastasis: indication of a common stem-cell origin of the exocrine and endocrine components. Virchows Arch. 2001;438:624-628.
18. Reid JD, Song-Lim Y, Petrelli M, et al. Ductuloinsular tumors of the pancreas: a light, electron microscopic and immunohistochemical study. Cancer. 1982;49:908-915.
19. Tomita T, Bhatia P, Gourley W. Mucin producing islet cell adenoma. Hum Pathol. 1981;12:850-853.
20. Verwest AM, Poelman M, Dinjens WNM, et al. Absence of a Pdx-1 mutation and normal gastroduodenal immunohistology in a child with pancreatic agenesis. Virchows Arch. 2000;437:680-684.
21. Young Song S, Gannon M, Washington MK, et al. Expansion of Pdx-1 expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor-alpha. Gastroenterology. 1999;117:1416-1426.
22. Zumkeller W. Nesidioblastosis. Endocr Relat Cancer. 1999;6:421-428.