Pioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI) in patients with type 2 diabetes

Current Medical Research and Opinion

Volumn 20, Issue 5, 2004, Pages 723-728

  Tan, Meng H ^a   Glazer, N Bradly ^b   Johns, Don ^a   Widel, Mario ^a   Gilmore, Kathryn J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b TAKEDA PHARMACEUTICALS   (United States)

Author keywords

HOMA S; Insulin sensitivity; Pioglitazone; QUICKI

Indexed keywords

ALANINE AMINOTRANSFERASE; C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; METFORMIN; PIOGLITAZONE; PLACEBO; SULFONYLUREA; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CALCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIABETES CONTROL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; EDEMA; EVALUATION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIVER TOXICITY; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOMES RESEARCH; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; RELIABILITY; SIDE EFFECT; TECHNIQUE; WEIGHT GAIN;

ANALYSIS OF VARIANCE; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MALE; METFORMIN; SULFONYLUREA COMPOUNDS; THIAZOLIDINEDIONES;

EID: 2542432893     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079904125003386     Document Type: Article

References (27)

1. Stumvoll M, Haring HU. Glitazones: clinical effects and molecular mechanisms. Ann Med 2002;34:217-24
2. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Int Med 2003;3:25-33
3. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Int Med 1999; 131:281-303
4. Miyazaki Y, Mahankali A, Matsuda M, et al. Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care 2001;224:710-19
5. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;3:E214-23
6. Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol 1979;237: E214-E223
7. Radziuk J. Insulin sensitivity and its measurement: structural commonalities among the methods. J Clin Endocrinol Metab 2000;85:4426-29
8. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-19
9. Rudenski AS, Matthews DR, Levy JC, Turner RC. Understanding 'insulin resistance': both glucose resistance and insulin resistance are required to model human diabetes. Metabolism 1991;40:908-17
10. Levy JC, Matthews DR, Hermans MP. Correct Homeostasis Model Assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998;21:2191-92
11. Katz A, Nambi SS, Mather K, et al. Quantitative Insulin Check Index: a simple accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000;85:2402-10
12. Katsuki A, Sumida Y, Gabazza EC, et al. QUICKI is useful for following improvements in insulin sensitivity after therapy in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2002;87:2906-8
13. Yokoyama H, Emoto M, Fujiwara K, et al. Quantitative insulin sensitivity check index and the reciprocal index of Homeostasis Model Assessment in normal range weight and moderately obese type 2 diabetic patients. Diabetes Care 2003;26:2426-32
14. Aronoff S, Rosenblatt S, Braithwaite S, et al. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes. Diabetes Care 2000;23:1605-11
15. Kipnes MS, Krosnick A, Rendell MS, et al. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: A randomized, placebo-controlled study. Am J Med 2001;111:10-17
16. Einhorn D, Rendell M, Rosenzweig J, et al. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. Clin Ther 2000;22:1395-409
17. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979;28:1039-57
18. Steel RGD, Torrie JH. Principles and procedures of statistics. New York: McGraw-Hill Book Company; 1960
19. Miyazaki Y, Matsuda M, DeFronzo RA. Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care 2002;25:517-23
20. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-70
21. Bonora E, Targher G, Alberiche M, et al. Homeostasis Model Assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000;23:57-63
22. Perseghin G, Caumo A, Caloni M, et al. Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. J Clin Endocrinol Metab 86:4776-81
23. Katsuki, A, Sumida Y, Gabazza EC, et al. Homeostasis Model Assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes. Diabetes Care 2001;24:362-5
24. Haffner SM, Gonzales C, Miettinen H, et al. A prospective analysis of the HOMA model: the Mexico City Diabetes Study. Diabetes Care 1996;19:1138-41
25. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart Study. Diabetes Care; 1997:20:1087-92
26. Mather KJ, Hunt AE, Steinberg HO, et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001;86:5457-64
27. Pavo I, Jermendy G, Varkonyi TT, et al. Effect of Pioglitazone Compared with Metformin on Glycemic Control and Indicators of Insulin Sensitivity in Recently Diagnosed Patients with Type 2 Diabetes. J Clin Endocrinol Metab 2003;88:1637-45